A detailed micrometer scale investigation of the solvent bonding process for microfluidic chip fabrication

RSC Advances ◽  
2014 ◽  
Vol 4 (11) ◽  
pp. 5371 ◽  
Author(s):  
Martin Laher ◽  
Sabine Hild
Keyword(s):  
Microfluidic Chip ◽  
Bonding Process ◽  
Chip Fabrication ◽  
Solvent Bonding ◽  
Micrometer Scale

Plasma free reversible and irreversible microfluidic bonding

Lab on a Chip ◽  
2017 ◽  
Vol 17 (2) ◽  
pp. 267-273 ◽  
Author(s):  
M. Chu ◽  
T. T. Nguyen ◽  
E. K. Lee ◽  
J. L. Morival ◽  
M. Khine
Keyword(s):  
Microfluidic Chip ◽  
Bonding Process ◽  
Cell Micropatterning ◽  
Chip Fabrication

We demonstrate a novel bonding process that allows for facile multilayer microfluidic chip fabrication and is compatible with cell micropatterning.

Optimization of hybrid microfluidic chip fabrication methods for biomedical application

2020 ◽  
Vol 24 (9) ◽  
Author(s):  
Sanja Kojić ◽  
Slobodan Birgermajer ◽  
Vasa Radonić ◽  
Ivana Podunavac ◽  
Jovana Jevremov ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Biomedical Application ◽  
Chip Fabrication

scholarly journals A Method for Manufacturing Flexible Microfluidic Chip Based on Soluble Material

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Junyao Wang ◽  
Xingyu Chen ◽  
Huan Liu ◽  
Gongchen Sun ◽  
Yunpeng Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Dissolution Rate ◽  
Microfluidic Chip ◽  
Experimental Studies ◽  
Bonding Process ◽  
Manufacturing Cost ◽  
Processing Conditions ◽  
Microfluidic Chips ◽  
Novel Method ◽  
Soluble Material

In this paper, a novel method for manufacturing flexible microfluidic chips without bonding process is proposed, which combines 3D printing technology and material dissolution technology. The manufacturing process of the microfluidic chip is as follows: a soluble HIPS mold with a preset shape is manufactured by 3D printing and placed in a molten PDMS solution for solidification. Soak in the limonene material to dissolve the mold and form a microchannel in the cured PDMS. Experimental studies have shown that the temperature and concentration of the limonene solution have an important effect on the dissolution rate. A 0.62 cm3 HIPS mold has the fastest dissolution rate at 100°C and 50% concentration. The proposed method provided a new idea for fabricating flexible microfluidic chip. Compared to bonding process, it has the characteristics of not relying on complicated processing conditions and low manufacturing cost.

The Microchannel of Microfluidic Chip Fabrication by Micro-Powder Blasting

2009 ◽  
Vol 76-78 ◽  
pp. 367-372
Author(s):  
Chiung Fang Huang ◽  
Yung Kang Shen ◽  
Yi Lin ◽  
Chi Wei Wu
Keyword(s):  
Microfluidic Chip ◽  
High Speed ◽  
Gas Flow ◽  
Erosion Resistance ◽  
Processing Parameters ◽  
Powder Size ◽  
Dimethyl Siloxane ◽  
Powder Blasting ◽  
Processing Procedure ◽  
Chip Fabrication

The process of micro-powder blasting is the high speed gas flow which mixed the micro-particle and gas to impact the brittle substrate by the specialized nozzle. This paper combined various diameters Al2O3 eroding particle with a novel masking technique to fabricate the pattern channels in soda glass with a width to 2000 μm and depth down to 1631 μm. The masking technology for fabricating microchannel is consisted by the combination of two polymers: 1) the elastic and thermal-curable poly-(dimethyl siloxane) (PDMS) for its erosion resistance and 2) the brittle epoxy resin SU-8 for its photosensitivity. This paper discusses the processing procedure by the different processing parameters (micro-powder impact pressure, the distance between nozzle and substrate, micro-powder size, and micro-powder impact time) to find the optimal process. The results show that the micro-powder size is the most important factor for the depth of microchannel of microfluidic chip. The surface roughness of microchannel of microfluidic chip is nearly 5-6μm.

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