scholarly journals Nanostructured palladium-reduced graphene oxide platform for high sensitive, label free detection of a cancer biomarker

RSC Advances ◽  
2014 ◽  
Vol 4 (5) ◽  
pp. 2267-2273 ◽  
Author(s):  
Vinod Kumar ◽  
Saurabh Srivastava ◽  
Sima Umrao ◽  
Ram Kumar ◽  
Gopal Nath ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Cancer Biomarker ◽  
Label Free ◽  
Reduced Graphene ◽  
Label Free Detection

scholarly journals NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes

Carbon ◽  
2021 ◽  
Vol 179 ◽  
pp. 514-522
Author(s):  
Jagriti Sethi ◽  
Ahmed Suhail ◽  
Mina Safarzadeh ◽  
Anas Sattar ◽  
Yinghui Wei ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Label Free ◽  
Screen Printed Electrodes ◽  
Reduced Graphene ◽  
Label Free Detection ◽  
Screen Printed

Ultrasensitive Label-Free Detection of PNA–DNA Hybridization by Reduced Graphene Oxide Field-Effect Transistor Biosensor

ACS Nano ◽  
2014 ◽  
Vol 8 (3) ◽  
pp. 2632-2638 ◽  
Author(s):  
Bingjie Cai ◽  
Shuting Wang ◽  
Le Huang ◽  
Yong Ning ◽  
Zhiyong Zhang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Dna Hybridization ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Label Free ◽  
Reduced Graphene ◽  
Label Free Detection ◽  
Effect Transistor

Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposite for the ultrasensitive detection of cancer biomarker matrix metalloproteinase-1

The Analyst ◽  
2021 ◽  
Author(s):  
Xinke Liu ◽  
Lu-Yin Lin ◽  
Fu-Yen Tseng ◽  
Yu-Cheng Tan ◽  
Jian Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Matrix Metalloproteinase ◽  
Gold Nanoparticle ◽  
Reduced Graphene Oxide ◽  
Electrochemical Immunosensor ◽  
Ultrasensitive Detection ◽  
Label Free ◽  
Matrix Metalloproteinase 1 ◽  
Reduced Graphene ◽  
P Matrix

Matrix metalloproteinase-1 (MMP-1) is associated with many types of cancers, including oral, colorectal, and brain cancers. This paper describes the fabrication of an MMP-1 immunosensor based on a gold nanoparticle/polyethyleneimine/reduced...

scholarly journals A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

2020 ◽  
Vol 187 (5) ◽  
Author(s):  
Jagriti Sethi ◽  
Michiel Van Bulck ◽  
Ahmed Suhail ◽  
Mina Safarzadeh ◽  
Ana Perez-Castillo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Electrochemical Techniques ◽  
Differential Pulse ◽  
Electrochemical Determination ◽  
Label Free ◽  
Reduced Graphene ◽  
Electrochemically Reduced Graphene Oxide

AbstractA label-free biosensor is developed for the determination of plasma-based Aβ1–42 biomarker in Alzheimer’s disease (AD). The platform is based on highly conductive dual-layer of graphene and electrochemically reduced graphene oxide (rGO). The modification of dual-layer with 1-pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) is achieved to facilitate immobilization of H31L21 antibody. The effect of these modifications were studied with morphological, spectral and electrochemical techniques. The response of the biosensor was evaluated using differential pulse voltammetry (DPV). The data was acquired at a working potential of ~ 180 mV and a scan rate of 50 mV s−1. A low limit of detection (LOD) of 2.398 pM is achieved over a wide linear range from 11 pM to 55 nM. The biosensor exhibits excellent specificity over Aβ1–40 and ApoE ε4 interfering species. Thus, it provides a viable tool for electrochemical determination of Aβ1–42. Spiked human and mice plasmas were used for the successful validation of the sensing platform in bio-fluidic samples. The results obtained from mice plasma analysis concurred with the immunohistochemistry (IHC) and magnetic resonance imaging (MRI) data obtained from brain analysis.

Sign in / Sign up

Export Citation Format

Share Document