A direct and general one-pot approach to α-trifluoromethylthiolated amides, esters and carboxylic acids has been successfully developed under mild, catalytic and metal-free conditions.
N-heterocycles, namely 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones, have been synthesised in one pot via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids under metal-free conditions.