A metal-free tandem approach to prepare structurally diverse N-heterocycles: synthesis of 1,2,4-oxadiazoles and pyrimidinones

2014 ◽  
Vol 38 (7) ◽  
pp. 3062-3070 ◽  
Author(s):  
Puneet K. Gupta ◽  
Mohd. Kamil Hussain ◽  
Mohd. Asad ◽  
Ruchir Kant ◽  
Rohit Mahar ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free

N-heterocycles, namely 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones, have been synthesised in one pot via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids under metal-free conditions.

Formal α-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles

2020 ◽  
Vol 56 (20) ◽  
pp. 3073-3076 ◽  
Author(s):  
Francesca Franco ◽  
Sara Meninno ◽  
Maurizio Benaglia ◽  
Alessandra Lattanzi
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free

A direct and general one-pot approach to α-trifluoromethylthiolated amides, esters and carboxylic acids has been successfully developed under mild, catalytic and metal-free conditions.

One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids

Synthesis ◽  
2013 ◽  
Vol 46 (03) ◽  
pp. 320-330 ◽  
Author(s):  
Danfeng Huang ◽  
Yulai Hu ◽  
Teng Niu ◽  
Ke-Hu Wang ◽  
Changming Xu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free ◽  
Weinreb Amides

An Efficient Acid- and Metal-Free One-Pot Synthesis of Benzothiazoles from Carboxylic Acids.

ChemInform ◽  
2006 ◽  
Vol 37 (7) ◽  
Author(s):  
Santosh Rudrawar ◽  
Atul Kondaskar ◽  
Asit K. Chakraborti
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

ChemInform Abstract: One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids.

ChemInform ◽  
2014 ◽  
Vol 45 (29) ◽  
pp. no-no
Author(s):  
Teng Niu ◽  
Ke-Hu Wang ◽  
Danfeng Huang ◽  
Changming Xu ◽  
Yingpeng Su ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free ◽  
Weinreb Amides

An Efficient Acid- and Metal-Free One-Pot Synthesis of Benzothiazoles from Carboxylic Acids

Synthesis ◽  
2005 ◽  
Vol 2005 (15) ◽  
pp. 2521-2526 ◽  
Author(s):  
Asit Chakraborti ◽  
Santosh Rudrawar ◽  
Atul Kondaskar
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

Oxidative C–C Bond Cleavage for the Synthesis of Aryl Carboxylic Acids from Aryl Alkyl Ketones

Synlett ◽  
2018 ◽  
Vol 29 (11) ◽  
pp. 1505-1509 ◽  
Author(s):  
Meichao Li ◽  
Zhenlu Shen ◽  
Liang Xu ◽  
Shengpeng Wang ◽  
Bajin Chen ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Bond Cleavage ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Optimal Reaction

A metal-free and one-pot two-step synthesis of aryl carboxylic acids from aryl alkyl ketones has been achieved. The reactions were performed with iodine as the catalyst, DMSO and TBHP as the oxidants. Under the optimal reaction conditions, a number of aryl alkyl ketones could be converted into their corresponding aryl carboxylic acids in good to excellent yields (up to 94%).

scholarly journals Trichloroacetamidate Triggered Expeditious and Novel Synthesis of N-Acylbenzotriazoles

SynOpen ◽  
2021 ◽  
Author(s):  
Vinod K Tiwari ◽  
MANGAL SINGH YADAV ◽  
Manoj K Jaiswal ◽  
Sunil Kumar
Keyword(s):  
Carboxylic Acids ◽  
Easy Access ◽  
One Pot ◽  
Diverse Range ◽  
Free Condition ◽  
Metal Free ◽  
Activation Pathway ◽  
Novel Synthesis ◽  
Facile Route

A facile route for the synthesis of diverse range of N-acylbenzotriazole derivatives from corresponding carboxylic acids has been established through carbonyl activation pathway. In this method, trichloroacetonitrile is performed as an effective reagent for an easy access of N-acylbenzotriazoles which was simply proceed through the activation of carboxylic acids via in situ imidate formation in anhydrous 1,2 dichloroethane followed by addition of 1H-benzotriazole at 80 oC for 3-4 hours. Easy handling, one-pot, and metal-free condition demonstrate the notable merits of the devised protocol.

Metal-Free Hydrogenation and One-pot Amidation with Carboxylic Acids of Nitroaromatics using S8 or CS2

2018 ◽  
Vol 21 (28) ◽  
Author(s):  
Yan Fang Sun ◽  
Guo He Xu ◽  
Min Jie Gao ◽  
Qiu Ling Hu ◽  
Jing Jun Ma
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free
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