Lithium tert-butoxide mediated α-alkylation of ketones with primary alcohols under transition-metal-free conditions

RSC Advances ◽  
2013 ◽  
Vol 3 (21) ◽  
pp. 7739 ◽  
Author(s):  
Yu-Feng Liang ◽  
Xin-Feng Zhou ◽  
Shi-Ya Tang ◽  
Yao-Bing Huang ◽  
Yi-Si Feng ◽  
...  
Keyword(s):  
Transition Metal ◽  
Primary Alcohols ◽  
Metal Free

Transition-metal-free aerobic oxidation of primary alcohols to carboxylic acids

2013 ◽  
Vol 37 (6) ◽  
pp. 1700 ◽  
Author(s):  
Jing Wang ◽  
Chao Liu ◽  
Jiwen Yuan ◽  
Aiwen Lei
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
Aerobic Oxidation ◽  
Primary Alcohols ◽  
Metal Free

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Synthesis ◽  
2019 ◽  
Vol 51 (19) ◽  
pp. 3723-3735 ◽  
Author(s):  
Eiji Kobayashi ◽  
Hideo Togo
Keyword(s):  
Transition Metal ◽  
Primary Alcohols ◽  
Successive Treatment ◽  
One Pot ◽  
Metal Free ◽  
Methyl Sulfide

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc)2 in the presence of TEMPO, NH2OH, and then NCS, followed by reaction with alkynes in the presence of Et3N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc)2 in the presence of TEMPO, PhNHNH2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et3N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.

ChemInform Abstract: Transition-Metal-Free Aerobic Oxidation of Primary Alcohols to Carboxylic Acids.

ChemInform ◽  
2013 ◽  
Vol 44 (45) ◽  
pp. no-no
Author(s):  
Jing Wang ◽  
Chao Liu ◽  
Jiwen Yuan ◽  
Aiwen Lei
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
Aerobic Oxidation ◽  
Primary Alcohols ◽  
Metal Free

Chemoselective and Metal-Free Synthesis of Aryl Esters from the Corresponding Benzylic Alcohols in Aqueous Medium Using TBHP/TBAI as an Efficient Catalytic System

Synlett ◽  
2018 ◽  
Vol 29 (16) ◽  
pp. 2208-2212
Author(s):  
Sanjay Bhar ◽  
Sneha Nandy ◽  
Avishek Ghatak ◽  
Asit Das
Keyword(s):  
Transition Metal ◽  
Catalytic Amount ◽  
High Yield ◽  
Primary Alcohols ◽  
Benzylic Alcohols ◽  
Metal Free ◽  
Tishchenko Reaction ◽  
Tert Butyl Hydroperoxide ◽  
Wide Range ◽  
Tetrabutylammonium Iodide

A novel and transition-metal-free strategy has been developed for the synthesis of aryl esters starting from corresponding benzylic primary alcohols as the exclusive substrates using tert-butyl hydroperoxide (TBHP) as a terminal oxidant in the presence of catalytic amount of tetrabutylammonium iodide (TBAI) and imidazole, where the aliphatic alcohols remained unaffected. These reactions are highly chemoselective and associated with high yield and wide applicability accommodating a wide range of substituents. Excellent chemoselectivity has also been demonstrated through intramolecular competition experiments. This protocol can be considered as an important analogue of Tishchenko reaction using benzylic alcohols as the substrates instead of benzaldehydes.

Transition-metal-free catalytic hydroboration reduction of amides to amines

2020 ◽  
Vol 7 (21) ◽  
pp. 3515-3520
Author(s):  
Wubing Yao ◽  
Jiali Wang ◽  
Aiguo Zhong ◽  
Shiliang Wang ◽  
Yinlin Shao
Keyword(s):  
Transition Metal ◽  
Selective Catalytic Reduction ◽  
Catalytic Reduction ◽  
Value Added ◽  
Metal Free

The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

2019 ◽  
Author(s):  
Arumugavel Murugan ◽  
Venkata Nagarjuna Babu ◽  
Nagaraj Sabarinathan ◽  
Sharada Duddu. S
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Practical Approach ◽  
Hypervalent Iodine ◽  
Radical Mechanism ◽  
Photoredox Catalysis ◽  
Metal Free

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Selective Oxidation of Alcohols Catalyzed by a Transition Metal-Free System of NHPI/DDQ/NaNO2

2011 ◽  
Vol 32 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Lipeng ZHOU ◽  
Chaofeng ZHANG ◽  
Tao FANG ◽  
Bingbing ZHANG ◽  
Ying WANG ◽  
...  
Keyword(s):  
Transition Metal ◽  
Selective Oxidation ◽  
Free System ◽  
Metal Free ◽  
Oxidation Of Alcohols

Defect engineering and characterization of active sites for efficient electrocatalysis

Nanoscale ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 3327-3345
Author(s):  
Xuecheng Yan ◽  
Linzhou Zhuang ◽  
Zhonghua Zhu ◽  
Xiangdong Yao
Keyword(s):  
Transition Metal ◽  
Active Sites ◽  
Defect Engineering ◽  
Metal Free

This review highlights recent advancements in defect engineering and characterization of both metal-free carbons and transition metal-based electrocatalysts.

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