A water-soluble conjugated polymer brush with multihydroxy dendritic side chains

2013 ◽  
Vol 4 (20) ◽  
pp. 5243 ◽  
Author(s):  
Li Zhou ◽  
Junlong Geng ◽  
Guan Wang ◽  
Jie Liu ◽  
Bin Liu
Keyword(s):  
Conjugated Polymer ◽  
Polymer Brush ◽  
Water Soluble ◽  
Side Chains

Polymer Brush-Stabilized Polyplex for a siRNA Carrier with Long Blood Circulatory Half-Life

2008 ◽  
Vol 47-50 ◽  
pp. 762-764 ◽  
Author(s):  
Arihiro Kano ◽  
Takeshi Yamano ◽  
Sun Won Choi ◽  
Atsushi Maruyama
Keyword(s):  
Delivery System ◽  
Half Life ◽  
Blood Circulation ◽  
Sirna Delivery ◽  
Polymer Brush ◽  
Water Soluble ◽  
Side Chains ◽  
Grafting Ratio ◽  
Interfering Rna

Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We attempted to develop a delivery system, which enables siRNA to demonstrate high stability and long blood circulation. We synthesized a series of bottlebrush-type copolymers (BBCs) possessing polycationic backbone (less than 30 wt%) and abundant water-soluble side chains (more than 70 wt%) as siRNA carrier. A siRNA complexed with the BBC was resistant to nuclease and stable in plasma. Especially, the BBC (10 wt% PLL and 90 wt% PEG) having higher grafting ratio (≈ 90 wt%) of water-soluble side chains showed 100-times enhanced stability of siRNA in mouse bloodstream in vivo. Surprisingly, even when the BBC and siRNA separately injected into mouse at 20 min interval, the BBC increased blood half life of the siRNA. These results suggest that the BBC has higher selectivity in its ionic interaction to siRNA than other anionic substance in blood components. To our knowledge, this is the first report of siRNA delivery carrier which prolonged blood circulation of siRNA without resource-consuming preparation process.

A water-soluble phosphorescent conjugated polymer brush for tumor-targeted photodynamic therapy

2017 ◽  
Vol 8 (38) ◽  
pp. 5836-5844 ◽  
Author(s):  
Pengfei Sun ◽  
Gaina Wang ◽  
Huanzhi Hou ◽  
Pengcheng Yuan ◽  
Weixing Deng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymer ◽  
Polymer Brush ◽  
Water Soluble ◽  
Hep G2 ◽  
Targeted Photodynamic Therapy

A glycopolymer modified water-soluble conjugated polymer brush was developed for Hep G2 tumor targeted photodynamic therapy.

A water-soluble conjugated polymer with azobenzol side chains based on “turn-on” effect for hypoxic cell imaging

2016 ◽  
Vol 7 (45) ◽  
pp. 6890-6894 ◽  
Author(s):  
Jie Li ◽  
Yan Yuan ◽  
Gaoshan Zeng ◽  
Xiang Li ◽  
Zhen Yang ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Cell Imaging ◽  
Water Soluble ◽  
Side Chains ◽  
Hypoxic Cell ◽  
Hypoxia Imaging ◽  
Turn On

A water-soluble conjugated polymer (WSCP) with enzymatic cleavable linkage (azobenzene) side chains for hypoxia imaging.

Novel Water-Soluble Cyclodextrin-Based Conjugated Polymer for Selective Host–Guest Interactions of Cationic Surfactant CTAB and Reverse FRET with Rhodamine B Tagged Adamantyl Guest

2016 ◽  
Vol 49 (15) ◽  
pp. 5587-5598 ◽  
Author(s):  
Atul Kumar Dwivedi ◽  
Ravinder Singh ◽  
Ashutosh Singh ◽  
Kung-Hwa Wei ◽  
Chu-Ya Wu ◽  
...  
Keyword(s):  
Cationic Surfactant ◽  
Rhodamine B ◽  
Conjugated Polymer ◽  
Water Soluble

A Conjugated Polymer Containing Arylazopyrazole Units in the Side Chains for Field‐Effect Transistors Optically Tunable by Near Infra‐Red Light

2020 ◽  
Vol 132 (33) ◽  
pp. 13948-13955
Author(s):  
Jianwu Tian ◽  
Zitong Liu ◽  
Wenlin Jiang ◽  
Dandan Shi ◽  
Liangliang Chen ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Field Effect ◽  
Field Effect Transistors ◽  
Red Light ◽  
Side Chains ◽  
Infra Red

Optically Tunable Field Effect Transistors with Conjugated Polymer Entailing Azobenzene Groups in the Side Chains

2019 ◽  
Vol 29 (12) ◽  
pp. 1807176 ◽  
Author(s):  
Jianwu Tian ◽  
Lulu Fu ◽  
Zitong Liu ◽  
Hua Geng ◽  
Yanan Sun ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Field Effect ◽  
Field Effect Transistors ◽  
Side Chains ◽  
Azobenzene Groups

Water-soluble oligofluorenes bearing N1-alkylcytosine side chains as turn-on and turn-off materials in telomere DNA length sensing

2020 ◽  
Vol 56 (74) ◽  
pp. 10914-10917
Author(s):  
Isao Yamaguchi ◽  
Ryoga Ooe ◽  
Aohan Wang
Keyword(s):  
Soft Materials ◽  
Water Soluble ◽  
Side Chains ◽  
Turn On

Soft materials for telomere DNA length sensing were developed.

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