Synthesis and photochromic properties of oxime derivatives of 2,3-diarylcyclopent-2-en-1-ones

2013 ◽  
Vol 12 (9) ◽  
pp. 1717 ◽  
Author(s):  
Valerii Z. Shirinian ◽  
Dmitry V. Lonshakov ◽  
Andrey G. Lvov ◽  
Alexey A. Shimkin ◽  
Mikhail M. Krayushkin
Keyword(s):  
Photochromic Properties ◽  
Oxime Derivatives ◽  
Derivatives Of

Coupling of Steroid O-(Carboxymethyl)oxime Derivatives with Amino Alcohols

1996 ◽  
Vol 61 (2) ◽  
pp. 288-297 ◽  
Author(s):  
Vladimír Pouzar ◽  
Ivan Černý
Keyword(s):  
Amino Acids ◽  
Hydroxy Group ◽  
Building Blocks ◽  
Amino Alcohols ◽  
New Approach ◽  
Alternative Synthesis ◽  
Oxime Derivatives ◽  
A Chain ◽  
Derivatives Of

New approach to the preparation of steroids with connecting bridge, based on an O-carboxymethyloxime (CMO) structure, and with terminal hydroxy group, is presented. 17-CMO derivatives of 3β-acetoxy- and 3β-methoxymethoxyandrost-5-en-17-one were condensed with α,ω-amino alcohols to give derivatives with a chain of seven to nine atoms. After THP-protection, these compounds were converted to 3-keto-4-ene derivatives. An alternative synthesis consisted in transformation of 17-CMO derivatives with bonded amino acids by reduction of the terminal carboxyl. The resulting compounds were designed as building blocks for the preparation of bis-haptens for sandwich immunoassays.

scholarly journals Novel O-alkyl Derivatives of Naringenin and Their Oximes with Antimicrobial and Anticancer Activity

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 679 ◽  
Author(s):  
Joanna Kozłowska ◽  
Ewa Grela ◽  
Dagmara Baczyńska ◽  
Agnieszka Grabowiecka ◽  
Mirosław Anioł
Keyword(s):  
Cancer Cell Line ◽  
Human Colon ◽  
Colon Cancer Cell Line ◽  
Human Colon Cancer ◽  
Anticancer Properties ◽  
Alkyl Derivatives ◽  
Ic50 Values ◽  
Oxime Derivatives ◽  
Derivatives Of ◽  
Ht 29

In our investigation, we concentrated on naringenin (NG)—a widely studied flavanone that occurs in citrus fruits. As a result of a reaction with a range of alkyl iodides, 7 novel O-alkyl derivatives of naringenin (7a–11a, 13a, 17a) were obtained. Another chemical modification led to 9 oximes of O-alkyl naringenin derivatives (7b–13b, 16b–17b) that were never described before. The obtained compounds were evaluated for their potential antibacterial activity against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The results were reported as the standard minimal inhibitory concentration (MIC) values and compared with naringenin and its known O-alkyl derivatives. Compounds 4a, 10a, 12a, 14a, 4b, 10b, 11b, and 14b were described with MIC of 25 µg/mL or lower. The strongest bacteriostatic activity was observed for 7-O-butylnaringenin (12a) against S. aureus (MIC = 6.25 µg/mL). Moreover, the antitumor effect of flavonoids was examined on human colon cancer cell line HT-29. Twenty-six compounds were characterized as possessing an antiproliferative activity stronger than that of naringenin. The replacement of the carbonyl group with an oxime moiety significantly increased the anticancer properties. The IC50 values below 5 µg/mL were demonstrated for four oxime derivatives (8b, 11b, 13b and 16b).

scholarly journals Quantification of Pentafluorobenzyl Oxime Derivatives of Long Chain Aldehydes by GC–MS Analysis

Lipids ◽  
2008 ◽  
Vol 43 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Viral V. Brahmbhatt ◽  
Christopher Nold ◽  
Carolyn J. Albert ◽  
David A. Ford
Keyword(s):  
Ms Analysis ◽  
Oxime Derivatives ◽  
Derivatives Of ◽  
Long Chain

scholarly journals Synthesis of 5-Keto-5-oxime Derivatives of Milbemycins and Their Activities against Microfilariae

1991 ◽  
Vol 55 (10) ◽  
pp. 2615-2621 ◽  
Author(s):  
Yoshihisa Tsukamoto ◽  
Kazuo Sato ◽  
Shigeru Mio ◽  
Soji Sugai ◽  
Toshiaki Yanai ◽  
...  
Keyword(s):  
Oxime Derivatives ◽  
Derivatives Of

scholarly journals Synthesis and antimicrobial activity of novel oxime derivatives of phenothiazine

2011 ◽  
Vol 2 (3) ◽  
pp. 388-393 ◽  
Author(s):  
Ashutosh Barve ◽  
Malleshappa Noolvi ◽  
Niharika Subhedar ◽  
Vishnu Dev Gupta ◽  
Gaurav Bhatia
Keyword(s):  
Antimicrobial Activity ◽  
Oxime Derivatives ◽  
Derivatives Of

Synthesis and photochromic properties of crown-containing styryl derivatives of naphthopyrans

2009 ◽  
Vol 22 (5) ◽  
pp. 537-545 ◽  
Author(s):  
Evgeni M. Glebov ◽  
Artjom B. Smolentsev ◽  
Valeri V. Korolev ◽  
Victor F. Plyusnin ◽  
Anna V. Chebunkova ◽  
...  
Keyword(s):  
Photochromic Properties ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document