In situ approach for testing the enantiopurity of chiral amines and amino alcohols by1H NMR

2014 ◽  
Vol 12 (3) ◽  
pp. 495-502 ◽  
Author(s):  
Sandeep Kumar Mishra ◽  
Sachin R. Chaudhari ◽  
N. Suryaprakash
Keyword(s):  
Amino Alcohols ◽  
Chiral Amines

scholarly journals In Situ Assembly of Octahedral Fe(II) Complexes for the Enantiomeric Excess Determination of Chiral Amines Using Circular Dichroism Spectroscopy

2012 ◽  
Vol 134 (9) ◽  
pp. 4398-4407 ◽  
Author(s):  
Justin M. Dragna ◽  
Gennaro Pescitelli ◽  
Lee Tran ◽  
Vincent M. Lynch ◽  
Eric V. Anslyn ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Enantiomeric Excess ◽  
Circular Dichroism Spectroscopy ◽  
Chiral Amines ◽  
Circular Dichroïsm

Highly Enantioselective Addition of In Situ Prepared Arylzinc to Aldehydes Catalyzed by a Series of Atropisomeric Binaphthyl-Derived Amino Alcohols

2006 ◽  
Vol 12 (15) ◽  
pp. 4115-4120 ◽  
Author(s):  
Gui Lu ◽  
Fuk Yee Kwong ◽  
Ji-Wu Ruan ◽  
Yue-Ming Li ◽  
Albert S. C. Chan
Keyword(s):  
Amino Alcohols ◽  
Enantioselective Addition

Quantitative chirality sensing of amines and amino alcohols via Schiff base formation with a stereodynamic UV/CD probe

2016 ◽  
Vol 14 (6) ◽  
pp. 1934-1939 ◽  
Author(s):  
Zeus A. De los Santos ◽  
Ransheng Ding ◽  
Christian Wolf
Keyword(s):  
Schiff Base ◽  
Amino Alcohols ◽  
Chiral Amines ◽  
Schiff Base Formation ◽  
Base Formation

A readily available probe is used for quantitative sensing of the concentration and ee of chiral amines and amino alcohols.

In situ reactions of amines and amino alcohols and their application to structural assignment by 1H NMR spectroscopy

1980 ◽  
Vol 45 (10) ◽  
pp. 2784-2803 ◽  
Author(s):  
Miloš Buděšínský ◽  
Zdeněk Samek ◽  
Miloš Tichý
Keyword(s):  
Nmr Spectroscopy ◽  
Structural Analysis ◽  
1H Nmr Spectroscopy ◽  
Amino Alcohols ◽  
Sample Tube ◽  
H Nmr ◽  
Structural Assignment ◽  
Trichloroacetyl Isocyanate ◽  
In Situ Reactions

The in situ reaction of amines with trichloroacetyl isocyanate (TAI) in the NMR sample tube was investigated as a tool in structural analysis by means of 1H NMR spectroscopy. Preferred conformations of the adducts were suggested which explain different behaviour of NH protons and the induced CH protons shifts. On the example of amino alcohols it was shown how to use the TAI method in combination with other in situ reactions (protonation, acetylation, trifluoroacetylation) for simultaneous differentiation between functional groups in polyfunctional molecules.

Pd-catalyzed Arylation of 1,2-Amino Alcohol Derivatives via beta-Carbon Elimination

Synlett ◽  
2021 ◽  
Author(s):  
Ruben Martin ◽  
Miguel Pericàs ◽  
Miriam Sau
Keyword(s):  
Amino Alcohol ◽  
Amino Alcohols ◽  
Aryl Halides ◽  
Entry Point ◽  
New Entry

Herein, we describe a Pd-catalyzed arylation of 1,2-amino alcohols with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to beta-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope – including challenging substrate combinations –, even in an enantioselective manner

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