Visible light-mediated oxidative quenching reaction to electron-rich epoxides: highly regioselective synthesis of α-bromo (di)ketones and mechanism study

2013 ◽  
Vol 11 (35) ◽  
pp. 5787 ◽  
Author(s):  
Lin Guo ◽  
Chao Yang ◽  
Lewei Zheng ◽  
Wujiong Xia
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis ◽  
Mechanism Study

Chemo- and Regioselective Synthesis of Alkynyl Cyclobutanes by Visible Light Photocatalysis

2018 ◽  
Vol 20 (21) ◽  
pp. 6808-6811 ◽  
Author(s):  
Chao Zhou ◽  
Tao Lei ◽  
Xiang-Zhu Wei ◽  
Zan Liu ◽  
Bin Chen ◽  
...  
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis ◽  
Visible Light Photocatalysis

ChemInform Abstract: Visible-Light-Induced Regioselective Synthesis of Polyheteroaromatic Compounds.

ChemInform ◽  
2016 ◽  
Vol 47 (29) ◽  
Author(s):  
Tanmay Chatterjee ◽  
Myung Gil Choi ◽  
Jun Kim ◽  
Suk-Kyu Chang ◽  
Eun Jin Cho
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis

scholarly journals Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ranjana Aggarwal ◽  
Naman Jain ◽  
Shilpa Sharma ◽  
Prince Kumar ◽  
Gyan Prakash Dubey ◽  
...  
Keyword(s):  
Visible Light ◽  
2D Nmr ◽  
Docking Studies ◽  
New Drugs ◽  
Regioselective Synthesis ◽  
Computational Techniques ◽  
Binding Studies ◽  
Visible Light Driven ◽  
In Silico Toxicity ◽  
Displacement Assay

AbstractIn recent times, fused azaheterocycles emerged as impressive therapeutic agents. Binding studies of such azaheterocycles with biomolecules is an important subject for pharmaceutical and biochemical studies aiming at the design and development of new drugs. Fused heterocyclic scaffolds, such as thiazolopyrmidines have long been used in the pharmaceutical industry for the treatment of various diseases. In this study, we have accomplished a regioselective synthesis of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines by the reaction of tetrahydropyrimidine-2(H)-thione with α-bromo-1,3-diketones, generated in situ from 1,3-diketones and NBS, using visible light as an inexpensive, green and renewable energy source under mild reaction conditions with wide-ranging substrate scope. The regioisomer was characterized unambiguously by 2D-NMR [1H-13C] HMBC and [1H-13C] HMQC spectroscopy. In silico toxicity data analysis showed the low toxicity risks of the synthesized compounds. Computational molecular docking studies were carried out to examine the interaction of thiazolo[3,2-a]pyrimidines with calf-thymus DNA (ct-DNA) and Bovine Serum Albumin (BSA). Moreover, different spectroscopic approaches viz. steady-state fluorescence, competitive displacement assay, UV–visible and circular dichroism (CD) along with viscosity measurements were employed to investigate the binding mechanisms of thiazolo[3,2-a]pyrimidines with DNA and BSA. The results thus obtained revealed that thiazolo[3,2-a]pyrimidines offer groove bindings with DNA and showed moderate bindings with BSA.

Visible-light mediated stereospecific C(sp2)–H difluoroalkylation of (Z)-aldoximes

2021 ◽  
Vol 19 (36) ◽  
pp. 7867-7874
Author(s):  
Qian Wang ◽  
Haiying Gong ◽  
Yifang Zhang ◽  
Yi Peng ◽  
Hua Chen ◽  
...  
Keyword(s):  
Visible Light ◽  
Mechanism Study

A visible light mediated stereospecific C(sp2)–H difluoroalkylation of (Z)-aldoximes to (E)-difluoroalkyated ketoximes has been described. A preliminary mechanism study showed that a difluoromethyl radical via an SET pathway was involved.

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