ChemInform Abstract: Visible-Light-Induced Regioselective Synthesis of Polyheteroaromatic Compounds.

ChemInform ◽  
2016 ◽  
Vol 47 (29) ◽  
Author(s):  
Tanmay Chatterjee ◽  
Myung Gil Choi ◽  
Jun Kim ◽  
Suk-Kyu Chang ◽  
Eun Jin Cho
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis

Chemo- and Regioselective Synthesis of Alkynyl Cyclobutanes by Visible Light Photocatalysis

2018 ◽  
Vol 20 (21) ◽  
pp. 6808-6811 ◽  
Author(s):  
Chao Zhou ◽  
Tao Lei ◽  
Xiang-Zhu Wei ◽  
Zan Liu ◽  
Bin Chen ◽  
...  
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis ◽  
Visible Light Photocatalysis

scholarly journals Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ranjana Aggarwal ◽  
Naman Jain ◽  
Shilpa Sharma ◽  
Prince Kumar ◽  
Gyan Prakash Dubey ◽  
...  
Keyword(s):  
Visible Light ◽  
2D Nmr ◽  
Docking Studies ◽  
New Drugs ◽  
Regioselective Synthesis ◽  
Computational Techniques ◽  
Binding Studies ◽  
Visible Light Driven ◽  
In Silico Toxicity ◽  
Displacement Assay

AbstractIn recent times, fused azaheterocycles emerged as impressive therapeutic agents. Binding studies of such azaheterocycles with biomolecules is an important subject for pharmaceutical and biochemical studies aiming at the design and development of new drugs. Fused heterocyclic scaffolds, such as thiazolopyrmidines have long been used in the pharmaceutical industry for the treatment of various diseases. In this study, we have accomplished a regioselective synthesis of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines by the reaction of tetrahydropyrimidine-2(H)-thione with α-bromo-1,3-diketones, generated in situ from 1,3-diketones and NBS, using visible light as an inexpensive, green and renewable energy source under mild reaction conditions with wide-ranging substrate scope. The regioisomer was characterized unambiguously by 2D-NMR [1H-13C] HMBC and [1H-13C] HMQC spectroscopy. In silico toxicity data analysis showed the low toxicity risks of the synthesized compounds. Computational molecular docking studies were carried out to examine the interaction of thiazolo[3,2-a]pyrimidines with calf-thymus DNA (ct-DNA) and Bovine Serum Albumin (BSA). Moreover, different spectroscopic approaches viz. steady-state fluorescence, competitive displacement assay, UV–visible and circular dichroism (CD) along with viscosity measurements were employed to investigate the binding mechanisms of thiazolo[3,2-a]pyrimidines with DNA and BSA. The results thus obtained revealed that thiazolo[3,2-a]pyrimidines offer groove bindings with DNA and showed moderate bindings with BSA.

Oxidative organophotoredox catalysis: a regioselective synthesis of 2-nitro substituted imidazopyridines and 3-substituted indoles, initiated by visible light

2016 ◽  
Vol 40 (11) ◽  
pp. 9694-9701 ◽  
Author(s):  
Snehlata Yadav ◽  
Madhulika Srivastava ◽  
Pratibha Rai ◽  
Bhartendu Pati Tripathi ◽  
Anu Mishra ◽  
...  
Keyword(s):  
Visible Light ◽  
Visible Light Irradiation ◽  
Room Temperature ◽  
Bond Formation ◽  
Light Irradiation ◽  
Regioselective Synthesis ◽  
Metal Free

Intramolecular C–N heterocyclization and C–C bond formation under visible light irradiation at room temperature was accomplished with a metal-free photoredox catalyst.

Visible-light-induced regioselective synthesis of polyheteroaromatic compounds

2016 ◽  
Vol 52 (22) ◽  
pp. 4203-4206 ◽  
Author(s):  
Tanmay Chatterjee ◽  
Myung Gil Choi ◽  
Jun Kim ◽  
Suk-Kyu Chang ◽  
Eun Jin Cho
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis

A method for visible-light-induced synthesis of heteroaryl-substituted polyheteroaromatics was developed.

Visible-light-promoted E-selective synthesis of α-fluoro-β-arylalkenyl sulfides via the deoxygenation/isomerization process

2021 ◽  
Author(s):  
Yuxiu Li ◽  
Xiangqian Li ◽  
Xiaowei Li ◽  
Dayong Shi
Keyword(s):  
Natural Products ◽  
Visible Light ◽  
Late Stage ◽  
Regioselective Synthesis ◽  
Selective Synthesis ◽  
Isomerization Process

Highly E-selective synthesis of α-fluoro-β-arylalkenyl sulfides: regioselective synthesis of α-fluoro-β-arylalkenyl sulfides has been established with gem-difluoroalkenes and sodium arysulfinates via visible-light-induced deoxygenation of S–O bonds and isomerization of alkenes. Moreover, the strategy is also applied in the late-stage modification of complex natural products and drugs.

Eosin Y catalyzed difunctionalization of styrenes using O2 and CS2: a direct access to 1,3-oxathiolane-2-thiones

2016 ◽  
Vol 18 (15) ◽  
pp. 4240-4244 ◽  
Author(s):  
Arvind K. Yadav ◽  
Lal Dhar S. Yadav
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis ◽  
Direct Access ◽  
Eosin Y ◽  
One Pot

An efficient, one-pot, highly regioselective synthesis of 1,3-oxathiolane-2-thiones from styrenes, CS2, atmospheric O2 and visible light is reported.

Visible-light-mediated Regioselective Synthesis of Novel Thiazolo[3,2-b][1,2,4]triazoles: Advantageous Synthetic Application of Aqueous Conditions

2022 ◽  
Author(s):  
Ranjana Aggarwal ◽  
Mona Hooda ◽  
Prince Kumar ◽  
Maria Carmen Torralba
Keyword(s):  
Green Chemistry ◽  
Visible Light ◽  
Power Source ◽  
Regioselective Synthesis ◽  
Water As Solvent ◽  
Aqueous Conditions ◽  
Synthetic Application

From a green chemistry perspective, sustainable irradiations as the power source and water as solvent have certainly grabbed the attention of chemists in recent times as these efforts reduce hazardous...

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