Magnetic PEGylated Pt3Co nanoparticles as a novel MR contrast agent: in vivo MR imaging and long-term toxicity study

Nanoscale ◽  
2013 ◽  
Vol 5 (24) ◽  
pp. 12464 ◽  
Author(s):  
Shengnan Yin ◽  
Zhiwei Li ◽  
Liang Cheng ◽  
Chao Wang ◽  
Yumeng Liu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Toxicity Study

scholarly journals Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1235
Author(s):  
Xiaohui Nan ◽  
Wenjia Lai ◽  
Dan Li ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Magnetic Domain ◽  
Bilayer Membrane ◽  
The Body ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast

Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. In this study, we tracked changes of BMs in major organs of mice up to 135 days after intravenous injection using a combination of several techniques. We not only confirmed the liver as the well-known targeted organs of BMs, but also found that BMs accumulated in the spleen. Besides, two major elimination paths, as well as the approximate length of time for BMs to be cleared from the mice, were revealed. Together, the results not only confirm that BMs have high biocompatibility, but also provide a long-term in-vivo assessment which may further help to forward the clinical applications of BMs as an MRI contrast agent.

Liquid oral magnetic particles as a gastrointestinal contrast agent for MR imaging: Efficacy in vivo

1993 ◽  
Vol 3 (1) ◽  
pp. 113-118 ◽  
Author(s):  
Daniel L Rubin ◽  
Holde H. Muller ◽  
Manrita K. Sidhu ◽  
Stuart W. Young ◽  
William A. Hunke ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Magnetic Particles

In Vivo Long-Term Magnetic Resonance Imaging Activity of Ferritin-Based Magnetic Nanoparticles versus a Standard Contrast Agent

2014 ◽  
Vol 57 (13) ◽  
pp. 5686-5692 ◽  
Author(s):  
Elsa Valero ◽  
Silvia Fiorini ◽  
Stefano Tambalo ◽  
Heriberto Busquier ◽  
José Callejas-Fernández ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging

The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent

Biomaterials ◽  
2012 ◽  
Vol 33 (31) ◽  
pp. 7794-7802 ◽  
Author(s):  
V. Vaijayanthimala ◽  
Po-Yun Cheng ◽  
Shih-Hua Yeh ◽  
Kuang-Kai Liu ◽  
Cheng-Hsiang Hsiao ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Term Stability ◽  
Long Term Stability

scholarly journals Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode MR imaging

2020 ◽  
Author(s):  
Miao Qin ◽  
Yueyou Peng ◽  
Mengjie Xu ◽  
Hui Yan ◽  
Yizhu Cheng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Clinical Diagnosis ◽  
Multimodal Imaging ◽  
Experimental Results ◽  
Dual Mode ◽  
3.0 T

Multimodal imaging technology were extensively studied over past few years, because they offered complementary diagnosis information, which can increase the accuracy of diagnosis. The synthesis of contrast agents via simplified methods are desired for the development of multimodal imaging. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T1-T2 dual-mode contrast agents were rationally designed and successfully fabricated by our group. In this system, the Fe3O4/Gd2O3 nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA) for better hydrophilia and biocompatibility. The results show that Ferrum (Fe) and Gadolinium (Gd) elements are homo-dispersity in the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxivity study at 3.0 T scanner demonstrates that the r1 value and r2 value of FGDA nanocubes reach up to 67.57 ± 6.2 mM-1s-1 and 24.2 ± 1.46 mM-1s-1. The images of T1-weighted and T2-weighted imaging in vivo demonstrate that FGDA nanocubes possess the ability of magnetic resonance (MR) imaging enhancement as dual-mode contrast agent. The above illustrated experimental results indicate that FGDA nanocubes can be applied in clinical diagnosis in future.

Sign in / Sign up

Export Citation Format

Share Document