scholarly journals Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

2013 ◽  
Vol 9 (7) ◽  
pp. 1576 ◽  
Author(s):  
Emanuel Gonçalves ◽  
Joachim Bucher ◽  
Anke Ryll ◽  
Jens Niklas ◽  
Klaus Mauch ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Mathematical Models

scholarly journals Control Design for Signal Transduction Networks

2009 ◽  
Vol 3 ◽  
pp. BBI.S2116 ◽  
Author(s):  
Chun-Liang Lin ◽  
Yuan-Wei Liu ◽  
Chia-Hua Chuang
Keyword(s):  
Signal Transduction ◽  
Mathematical Models ◽  
Dynamic Analysis ◽  
Control Strategy ◽  
Controller Design ◽  
Control Design ◽  
Effective Control ◽  
Analysis Model ◽  
Signal Transduction Networks ◽  
Design Idea

Signal transduction networks of biological systems are highly complex. How to mathematically describe a signal transduction network by systematic approaches to further develop an appropriate and effective control strategy is attractive to control engineers. In this paper, the synergism and saturation system (S-systems) representations are used to describe signal transduction networks and a control design idea is presented. For constructing mathematical models, a cascaded analysis model is first proposed. Dynamic analysis and controller design are simulated and verified.

Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling

2004 ◽  
Vol 1 (1) ◽  
pp. 159-169 ◽  
Author(s):  
H. Conzelmann ◽  
T. Sauter ◽  
E.D. Gilles ◽  
F. Allgöwer ◽  
J. Saez-Rodriguez ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Mathematical Models ◽  
Egf Receptor ◽  
Receptor Signalling ◽  
Signal Transduction Networks ◽  
Simulation Based

scholarly journals Maximization of information transmission influences selection of native phosphorelay architectures

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11558
Author(s):  
Rui Alves ◽  
Baldiri Salvadó ◽  
Ron Milo ◽  
Ester Vilaprinyo ◽  
Albert Sorribas
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Signal Transduction ◽  
Bacillus Subtilis ◽  
Mathematical Models ◽  
Information Transmission ◽  
Environmental Changes ◽  
Design Principles ◽  
Biological Design ◽  
Parameter Values ◽  
Selection Of

Phosphorelays are signal transduction circuits that sense environmental changes and adjust cellular metabolism. Five different circuit architectures account for 99% of all phosphorelay operons annotated in over 9,000 fully sequenced genomes. Here we asked what biological design principles, if any, could explain selection among those architectures in nature. We began by studying kinetically well characterized phosphorelays (Spo0 of Bacillus subtilis and Sln1 of Saccharomyces cerevisiae). We find that natural circuit architecture maximizes information transmission in both cases. We use mathematical models to compare information transmission among the architectures for a realistic range of concentration and parameter values. Mapping experimentally determined phosphorelay protein concentrations onto that range reveals that the native architecture maximizes information transmission in sixteen out of seventeen analyzed phosphorelays. These results suggest that maximization of information transmission is important in the selection of native phosphorelay architectures, parameter values and protein concentrations.

scholarly journals Mathematical Models of Protein Kinase Signal Transduction

2002 ◽  
Vol 9 (5) ◽  
pp. 957-970 ◽  
Author(s):  
Reinhart Heinrich ◽  
Benjamin G. Neel ◽  
Tom A. Rapoport
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Mathematical Models
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