scholarly journals Tackling the cancer signal transduction “Labyrinth”: A combinatorial use of biochemical tools with mathematical models will enhance the identification of optimal targets for each molecular defect

Cancer ◽  
2013 ◽  
Vol 120 (3) ◽  
pp. 316-322 ◽  
Author(s):  
Michalis V. Karamouzis ◽  
Athanasios G. Papavassiliou
Keyword(s):  
Signal Transduction ◽  
Mathematical Models ◽  
Molecular Defect ◽  
Cancer Signal Transduction

Cancer, Signal Transduction and Nanotechnology

2011 ◽  
Vol 8 (3) ◽  
pp. 254-260 ◽  
Author(s):  
Poulomi Sengupta ◽  
Sudipta Basu ◽  
Shiladitya Sengupta
Keyword(s):  
Signal Transduction ◽  
Cancer Signal Transduction

scholarly journals CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

2021 ◽  
Author(s):  
Megan Lo ◽  
Amnon Sharir ◽  
Michael D Paul ◽  
Hayarpi Torosyan ◽  
Christopher Agnew ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Primary Cilia ◽  
Molecular Mechanisms ◽  
Negative Regulator ◽  
Membrane Composition ◽  
Hh Signaling ◽  
Pathway Regulation ◽  
Patched 1 ◽  
Cancer Signal Transduction

The Hedgehog (HH) pathway is critical for development and adult tissue homeostasis. Aberrant HH signaling can cause congenital malformations, such as digit anomalies and holoprosencephaly, and other diseases, including cancer. Signal transduction is initiated by HH ligand binding to the Patched 1 (PTCH1) receptor on primary cilia, thereby releasing inhibition of Smoothened (SMO), a HH pathway activator. Although cholesterol and several oxysterol lipids, which are enriched in the ciliary membrane, play a crucial role in HH activation, the molecular mechanisms governing the regulation of these lipid molecules remain unresolved. Here, we identify Canopy 4 (CNPY4), a Saposin-like protein, as a regulator of the HH pathway that controls membrane sterol lipid levels. Cnpy4—/— embryos exhibit multiple defects consistent with HH signaling perturbations, most notably changes in digit number. Knockdown of Cnpy4 hyperactivates the HH pathway at the level of SMO in vitro, and elevates membrane levels of accessible sterol lipids such as cholesterol, an endogenous ligand involved in SMO activation. Thus, our data demonstrate that CNPY4 is a negative regulator that fine-tunes the initial steps of HH signal transduction, revealing a previously undescribed facet of HH pathway regulation that operates through control of membrane composition.

Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction

2013 ◽  
Vol 25 (3) ◽  
pp. 651-659 ◽  
Author(s):  
Francesco Giovinazzo ◽  
Giorgio Malpeli ◽  
Sara Zanini ◽  
Marco Parenti ◽  
Lorenzo Piemonti ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Pancreatic Carcinoma ◽  
Ectopic Expression ◽  
Cancer Signal Transduction

scholarly journals Control Design for Signal Transduction Networks

2009 ◽  
Vol 3 ◽  
pp. BBI.S2116 ◽  
Author(s):  
Chun-Liang Lin ◽  
Yuan-Wei Liu ◽  
Chia-Hua Chuang
Keyword(s):  
Signal Transduction ◽  
Mathematical Models ◽  
Dynamic Analysis ◽  
Control Strategy ◽  
Controller Design ◽  
Control Design ◽  
Effective Control ◽  
Analysis Model ◽  
Signal Transduction Networks ◽  
Design Idea

Signal transduction networks of biological systems are highly complex. How to mathematically describe a signal transduction network by systematic approaches to further develop an appropriate and effective control strategy is attractive to control engineers. In this paper, the synergism and saturation system (S-systems) representations are used to describe signal transduction networks and a control design idea is presented. For constructing mathematical models, a cascaded analysis model is first proposed. Dynamic analysis and controller design are simulated and verified.

Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling

2004 ◽  
Vol 1 (1) ◽  
pp. 159-169 ◽  
Author(s):  
H. Conzelmann ◽  
T. Sauter ◽  
E.D. Gilles ◽  
F. Allgöwer ◽  
J. Saez-Rodriguez ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Mathematical Models ◽  
Egf Receptor ◽  
Receptor Signalling ◽  
Signal Transduction Networks ◽  
Simulation Based

scholarly journals Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

2013 ◽  
Vol 9 (7) ◽  
pp. 1576 ◽  
Author(s):  
Emanuel Gonçalves ◽  
Joachim Bucher ◽  
Anke Ryll ◽  
Jens Niklas ◽  
Klaus Mauch ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Mathematical Models

scholarly journals Novel effects of Helicobacter pylori CagA on key genes of gastric cancer signal transduction: a comparative transfection study

2014 ◽  
Vol 73 (3) ◽  
Author(s):  
Farzam Vaziri ◽  
Shahin N. Peerayeh ◽  
Masoud Alebouyeh ◽  
Nader Maghsoudi ◽  
Pedram Azimzadeh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signal Transduction ◽  
Helicobacter Pylori ◽  
Key Genes ◽  
Cancer Signal Transduction ◽  
Transfection Study
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