Microencapsulation of tannic acid for oral administration to inhibit carbohydrate digestion in the gastrointestinal tract

2013 ◽  
Vol 4 (6) ◽  
pp. 899 ◽  
Author(s):  
Wei Zhao ◽  
Vidya Iyer ◽  
Floirendo P. Flores ◽  
Erik Donhowe ◽  
Fanbin Kong
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Tannic Acid ◽  
Carbohydrate Digestion

Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets

Amino Acids ◽  
2013 ◽  
Vol 45 (5) ◽  
pp. 1169-1177 ◽  
Author(s):  
Jun Zhang ◽  
Yulong Yin ◽  
Xu Gang Shu ◽  
Tiejun Li ◽  
Fengna Li ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Glutamate Receptors

scholarly journals Mucoadhesive Microspheres Containing Amoxicillin for Clearance of Helicobacter pylori

1998 ◽  
Vol 42 (10) ◽  
pp. 2492-2494 ◽  
Author(s):  
Naoki Nagahara ◽  
Yohko Akiyama ◽  
Masafumi Nakao ◽  
Mayumi Tada ◽  
Megumi Kitano ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Antimicrobial Agent ◽  
Extended Period ◽  
Mongolian Gerbils ◽  
Polymer Powder ◽  
Hydrogenated Castor Oil ◽  
H Pylori

ABSTRACT In an effort to augment the anti-Helicobacter pylorieffect of amoxicillin, mucoadhesive microspheres, which have the ability to reside in the gastrointestinal tract for an extended period, were prepared. The microspheres contained the antimicrobial agent and an adhesive polymer (carboxyvinyl polymer) powder dispersed in waxy hydrogenated castor oil. The percentage of amoxicillin remaining in the stomach both 2 and 4 h after oral administration of the mucoadhesive microspheres to Mongolian gerbils under fed conditions was about three times higher than that after administration in the form of a 0.5% methylcellulose suspension. The in vivo clearance ofH. pylori following oral administration of the mucoadhesive microspheres and the 0.5% methylcellulose suspension to infected Mongolian gerbils was examined under fed conditions. The mucoadhesive microspheres and the 0.5% methylcellulose suspension both showed anti-H. pylori effects in this experimental model of infection, but the required dose of amoxicillin was effectively reduced by a factor of 10 when the mucoadhesive microspheres were used. In conclusion, the mucoadhesive microspheres more effectively cleared H. pylori from the gastrointestinal tract than the 0.5% methylcellulose suspension due to the prolonged gastrointestinal residence time resulting from mucoadhesion. A dosage form consisting of mucoadhesive microspheres containing an appropriate antimicrobial agent should be useful for the eradication of H. pylori.

Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract

2011 ◽  
Vol 56 (3) ◽  
pp. 435-445 ◽  
Author(s):  
Tsuyoshi Goto ◽  
Mayuka Horita ◽  
Hiroyuki Nagai ◽  
Akifumi Nagatomo ◽  
Norihisa Nishida ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Glucose Absorption ◽  
Carbohydrate Digestion

scholarly journals MODERN ONCO DRUG FOR INTERNAL USE

2018 ◽  
Vol 6 (5) ◽  
pp. 440-461
Author(s):  
O. L. Orlova ◽  
L. L. Nikolaeva ◽  
L. A. Korol ◽  
M. V. Dmitrieva ◽  
A. P. Polozkova ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Anticancer Drugs ◽  
Active Pharmaceutical Ingredient ◽  
Pharmacological Action ◽  
The Body ◽  
Cytotoxic Drugs ◽  
New Drugs ◽  
Oral Dosage ◽  
Tissue Reactions

Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various therapeutic regimens are tested, expanding the possibilities of therapy and improving the results of treatment. Therefore, the adequate use of modern chemotherapy requires constant updating of information about anticancer drugs and methods of their use. Oral administration of drugs is the most natural and convenient way to introduce drugs into the human body. There are about 75% of orally administered drugs that have the ability to be absorbed in the gastrointestinal tract within 1−3 hours after administration. Oral dosage forms (DF) are most common due to the relative simplicity of their production, convenience of use, accuracy of dosing and high stability. Therefore, pharmaceutical companies often reproduce generics in the form of tablets and capsules for oral administration. However, most active pharmaceutical ingredient (API) are destroyed by the action of the gastrointestinal tract environment, which makes it impossible to use the oral administration. This review of the literature describes the main groups of anticancer drugs that are effective when taken orally.The aimof the study is to compile the information on the main groups of anticancer drugs used internally.Materials and methods.The object of the study was well-known anticancer drugs approved for oral administration. The study was conducted using search information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate), as well as State Register of Medicinal Remedies.Results and discussion.Analyzing the arsenal of cytotoxic drugs, it should be noted that antitumor substances are characterized by high chemical lability they are photosensitive, heat-labile, hygroscopic and hydrolytically unstable. These properties complicate both obtaining reproducible therapeutic effect when taken orally and technological inprocesses. In addition, anticancer drugs have mutagenic, teratogenic, sensitizing and allergenic effects.Conclusion.Lack of sufficient selectivity of the antitumor effect of cytotoxic drugs and a small breadth of pharmacological action require the use of DF, ensuring control of drug delivery to the body, including dosage accuracy and standard bioavailability. DF plays a very important role in the delivery of drugs to the lesion site. Capsules and coated tablets are necessarily created to avoid high toxicity of anticancer drugs and local tissue reactions when taken orally.

Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure

Nanoscale ◽  
2018 ◽  
Vol 10 (16) ◽  
pp. 7736-7745 ◽  
Author(s):  
Juan Li ◽  
Shengmei Yang ◽  
Runhong Lei ◽  
Weihong Gu ◽  
Yanxia Qin ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Oral Administration ◽  
Tio2 Nanoparticles ◽  
Anatase Tio2 ◽  
Mouse Gut Microbiota ◽  
Microbiota Structure

Chronic overconsumption of TiO2 NPs-containing foods, such as gum, candy and puddings, is likely to deteriorate the gastrointestinal tract and change the structures of microbiota.

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