Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract

2011 ◽  
Vol 56 (3) ◽  
pp. 435-445 ◽  
Author(s):  
Tsuyoshi Goto ◽  
Mayuka Horita ◽  
Hiroyuki Nagai ◽  
Akifumi Nagatomo ◽  
Norihisa Nishida ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Glucose Absorption ◽  
Carbohydrate Digestion

Protection against developing type 2 diabetes by coffee consumption: assessment of the role of chlorogenic acid and metabolites on glycaemic responses

2020 ◽  
Vol 11 (6) ◽  
pp. 4826-4833 ◽  
Author(s):  
Gary Williamson
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Chlorogenic Acid ◽  
Coffee Consumption ◽  
Glucose Absorption ◽  
Chlorogenic Acids ◽  
Carbohydrate Digestion

Coffee chlorogenic acids do not affect carbohydrate digestion directly, but modulate glucose absorption/utilisation, the latter through endogenous/gut microbiota metabolites.

The effect of dietary ratios of corn silage and alfalfa hay on carbohydrate digestion and retention time of feed particles in the gastrointestinal tract of steers

2009 ◽  
Vol 80 (5) ◽  
pp. 546-555 ◽  
Author(s):  
Taketo OBITSU ◽  
Masahiko GOTO ◽  
Toshihisa SUGINO ◽  
Kohzo TANIGUCHI ◽  
Kenichiro YUKIZANE ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Retention Time ◽  
Corn Silage ◽  
Alfalfa Hay ◽  
Carbohydrate Digestion

Artocarpus lacucha Extract and Oxyresveratrol Inhibit Glucose Transporters in Human Intestinal Caco-2 Cells

Planta Medica ◽  
2021 ◽  
Author(s):  
Matusorn Wongon ◽  
Nanteetip Limpeanchob
Keyword(s):  
Glucose Transport ◽  
Glucose Transporter ◽  
Glucose Transporters ◽  
Glucose Absorption ◽  
Culture Conditions ◽  
Glucose Transporter 1 ◽  
Glucose Transporter 2 ◽  
Sodium Dependent ◽  
Intestinal Glucose Absorption ◽  
Carbohydrate Digestion

AbstractReduction of intestinal glucose absorption might result from either delayed carbohydrate digestion or blockage of glucose transporters. Previously, oxyresveratrol was shown to inhibit α-glucosidase, but its effect on glucose transporters has not been explored. The present study aimed to assess oxyresveratrol-induced inhibition of the facilitative glucose transporter 2 and the active sodium-dependent glucose transporter 1. An aqueous extract of Artocarpus lacucha, Puag Haad, which is oxyresveratrol-enriched, was also investigated. Glucose transport was measured by uptake into Caco-2 cells through either glucose transporter 2 or sodium-dependent glucose transporter 1 according to the culture conditions. Oxyresveratrol (40 to 800 µM) dose-dependently reduced glucose transport, which appeared to inhibit both glucose transporter 2 and sodium-dependent glucose transporter 1. Puag Haad at similar concentrations also inhibited these transporters but with greater efficacy. Oxyresveratrol and Puag Haad could help reduce postprandial hyperglycemic peaks, which are considered to be most damaging in diabetics.

Effect of Vitamin D and Ca:P Ratios on Chick Gastrointestinal Tract

1956 ◽  
Vol 187 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Stanley N. Gershoff ◽  
D. Mark Hegsted
Keyword(s):  
Vitamin D ◽  
Gastrointestinal Tract ◽  
Intestinal Mucosa ◽  
Glucose Absorption ◽  
Feeding Diets ◽  
Ca:P Ratio ◽  
Effect Of Feeding

The effect of feeding diets containing various Ca:P ratios (4:1, 1:1, 1:2) to rachitic and nonrachitic chicks has been studied. The Ca:P ratios used had no significant effect on Ca absorption in chicks receiving vitamin D but were of importance in the Ca absorption of rachitic chicks. Vitamin D was found to increase Ca absorption in chick duodenum but had no effect on glucose absorption. Increased peristalsis was obtained when vitamin D or the least rachitogenic Ca:P ratio (1:1) was fed. A possible increase in intestinal mucosa respiration was also observed when vitamin D or the 1:1 Ca:P ratio was fed.

Inhibitory effects of Gymnema inodorum (Lour.) Decne leaf extracts and its triterpene saponin on carbohydrate digestion and intestinal glucose absorption

2021 ◽  
Vol 266 ◽  
pp. 113398
Author(s):  
Wanwisa Srinuanchai ◽  
Rawiwan Nooin ◽  
Pornsiri Pitchakarn ◽  
Jirarat Karinchai ◽  
Uthaiwan Suttisansanee ◽  
...  
Keyword(s):  
Glucose Absorption ◽  
Inhibitory Effects ◽  
Leaf Extracts ◽  
Triterpene Saponin ◽  
Intestinal Glucose Absorption ◽  
Carbohydrate Digestion

scholarly journals Flavonoids as Human Intestinal α-Glucosidase Inhibitors

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1939
Author(s):  
Elizabeth Barber ◽  
Michael J. Houghton ◽  
Gary Williamson
Keyword(s):  
Glucose Absorption ◽  
Inhibitory Effects ◽  
Antidiabetic Drug ◽  
Glucosidase Inhibitors ◽  
Acarbose Treatment ◽  
Ic50 Values ◽  
Intestinal Glucose Absorption ◽  
Inhibition Pattern ◽  
Carbohydrate Digestion ◽  
Enzyme Source

Certain flavonoids can influence glucose metabolism by inhibiting enzymes involved in carbohydrate digestion and suppressing intestinal glucose absorption. In this study, four structurally-related flavonols (quercetin, kaempferol, quercetagetin and galangin) were evaluated individually for their ability to inhibit human α-glucosidases (sucrase, maltase and isomaltase), and were compared with the antidiabetic drug acarbose and the flavan-3-ol(−)-epigallocatechin-3-gallate (EGCG). Cell-free extracts from human intestinal Caco-2/TC7 cells were used as the enzyme source and products were quantified chromatographically with high accuracy, precision and sensitivity. Acarbose inhibited sucrase, maltase and isomaltase with IC50 values of 1.65, 13.9 and 39.1 µM, respectively. A similar inhibition pattern, but with comparatively higher values, was observed with EGCG. Of the flavonols, quercetagetin was the strongest inhibitor of α-glucosidases, with inhibition constants approaching those of acarbose, followed by galangin and kaempferol, while the weakest were quercetin and EGCG. The varied inhibitory effects of flavonols against human α-glucosidases depend on their structures, the enzyme source and substrates employed. The flavonols were more effective than EGCG, but less so than acarbose, and so may be useful in regulating sugar digestion and postprandial glycaemia without the side effects associated with acarbose treatment.

Studies on the carbohydrate metabolism of sheep. 5. The effect of hyperglycaemia and of insulin on the rate of extrahepatic glucose assimilation

1952 ◽  
Vol 3 (2) ◽  
pp. 160 ◽  
Author(s):  
RL Reid
Keyword(s):  
Blood Glucose ◽  
General Circulation ◽  
Glucose Absorption ◽  
Partial Explanation ◽  
Intravenous Glucose ◽  
Glucose Injection ◽  
Direct Administration ◽  
Extrahepatic Tissues ◽  
Carbohydrate Digestion ◽  
Glucose Assimilation

Significant increases in the arterio-venous glucose difference have not been observed constantly in sheep either during the hyperglycaemia which follows intravenous glucose injection or during the period in which the blood glucose is falling after insulin administration. It is suggested that the low rate of extrahepatic glucose assimilation at hyperglycaemic levels provides a partial explanation of the relatively slow rate of clearance of injected glucose from the general circulation of ruminants. Blood-glucose curves, obtained after direct administration of glucose into the abomasum, are discussed in the light of these findings, and it is concluded that the rate of glucose absorption from the intestine of the sheep is low compared with the rate in non-ruminants. It is suggested further that hexokinase activity in the extrahepatic tissues of the sheep is relatively low, and that the findings described are conditioned principally by the nature of carbohydrate digestion and metabolism in the ruminant.

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