Enzymatic preparation of a redox-responsive hydrogel for encapsulating and releasing living cells

2014 ◽  
Vol 50 (44) ◽  
pp. 5895-5898 ◽  
Author(s):  
Kousuke Moriyama ◽  
Kosuke Minamihata ◽  
Rie Wakabayashi ◽  
Masahiro Goto ◽  
Noriho Kamiya
Keyword(s):  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Mammalian Cells ◽  
Living Cells ◽  
Cross Linking ◽  
Enzymatic Preparation ◽  
Poly Ethylene Glycol ◽  
Redox Responsive ◽  
Poly Ethylene

Horseradish peroxidase-mediated oxidative cross-linking of a thiolated poly(ethylene glycol) allows the preparation of a hydrogel that can encapsulate and release living mammalian cells.

Enzyme-mediated preparation of hydrogels composed of poly(ethylene glycol) and gelatin as cell culture platforms

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 3070-3073 ◽  
Author(s):  
Kousuke Moriyama ◽  
Rie Wakabayashi ◽  
Masahiro Goto ◽  
Noriho Kamiya
Keyword(s):  
Cell Culture ◽  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Cell Sheet ◽  
Viable Cell ◽  
Poly Ethylene Glycol ◽  
Redox Responsive ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Horseradish peroxidase-mediated preparation of redox-responsive hydrogels composed of thiolated poly(ethylene glycol) and gelatin allowed the proliferation of cells on the gel and the harvest as a viable cell sheet.

scholarly journals Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen

2010 ◽  
Vol 6 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Evan A. Scott ◽  
Michael D. Nichols ◽  
Rebecca Kuntz-Willits ◽  
Donald L. Elbert
Keyword(s):  
Ethylene Glycol ◽  
Living Cells ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Modular Scaffolds

Cross-linking of cellulose and poly(ethylene glycol) with citric acid

2015 ◽  
Vol 90 ◽  
pp. 21-24 ◽  
Author(s):  
Pamela de Cuadro ◽  
Tiina Belt ◽  
Katri S. Kontturi ◽  
Mehedi Reza ◽  
Eero Kontturi ◽  
...  
Keyword(s):  
Citric Acid ◽  
Ethylene Glycol ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Best of both worlds: Diels–Alder chemistry towards fabrication of redox-responsive degradable hydrogels for protein release

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74757-74764 ◽  
Author(s):  
Ismail Altinbasak ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Ethylene Glycol ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protein Release ◽  
Poly Ethylene Glycol ◽  
Diels Alder Reaction ◽  
Redox Responsive ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Poly(ethylene glycol)-based redox-responsive hydrogels have been preparedviathe Diels–Alder reaction between a furan-containing hydrophilic copolymer and a disulfide-containing bis-maleimide based crosslinker.

Preparation and Properties of a Hydrolytically Stable Cyclooctyne-Containing Polymer

Synlett ◽  
2018 ◽  
Vol 29 (19) ◽  
pp. 2535-2541
Author(s):  
Alex Adronov ◽  
Kelvin Li ◽  
Stuart McNelles
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Monomethyl Ether ◽  
Phenylene Vinylene ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Ethylene Glycol Monomethyl Ether ◽  
Glycol Monomethyl Ether ◽  
Poly Ethylene

A poly[(phenylene vinylene)-co-dibenzocyclooctyne] polymer prepared by Wittig polymerization chemistry between dibenzocyclooctyne bisaldehyde [DIBO-(CHO)2] and bis(triethyleneglycol)phenylbis(tributylphosphonium) dibromide is reported. The resulting polymer exhibits moderate molecular weight (Mn: 10.5 kDa, Mw: 21.3 kDa, Ð: 2.02) and is fluorescent. It could be readily functionalized by strain-promoted alkyne-azide cycloadditon with different azides, and fluorescence of the polymer was preserved after functionalization. Grafting azide-terminated 5 kDa poly(ethylene glycol) monomethyl ether chains drastically affected the solubility of the polymer. Cross-linking the polymer with poly(ethylene glycol) that was terminated at both ends with azide groups gave access to a fluorescent organogel that could be dried and reswollen with water to form a hydrogel.

Enzymatically crosslinked hydrogels based on linear poly(ethylene glycol) polymer: performance and mechanism

2017 ◽  
Vol 8 (45) ◽  
pp. 7017-7024 ◽  
Author(s):  
Kaixuan Ren ◽  
Bin Li ◽  
Qinghua Xu ◽  
Chunsheng Xiao ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene ◽  
Performance And Mechanism

A horseradish peroxidase-catalyzed hydrogel based on a double-end tyramine conjugated linear poly(ethylene glycol) polymer is developed and clarified.

Synthesis of Sulfhydryl Cross-Linking Poly(Ethylene Glycol)-Peptides and Glycopeptides as Carriers for Gene Delivery†

2002 ◽  
Vol 13 (2) ◽  
pp. 232-239 ◽  
Author(s):  
Youmie Park ◽  
Kai Y. Kwok ◽  
Chawki Boukarim ◽  
Kevin G. Rice
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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