A paper-based photoelectrochemical immunoassay for low-cost and multiplexed point-of-care testing

2013 ◽  
Vol 49 (32) ◽  
pp. 3294 ◽  
Author(s):  
Panpan Wang ◽  
Lei Ge ◽  
Shenguang Ge ◽  
Jinghua Yu ◽  
Mei Yan ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Point Of Care Testing ◽  
Photoelectrochemical Immunoassay

scholarly journals Point-of-Care Testing-the Key in the Battle against SARS-CoV-2 Pandemic

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1464
Author(s):  
Florina Silvia Iliescu ◽  
Ana Maria Ionescu ◽  
Larisa Gogianu ◽  
Monica Simion ◽  
Violeta Dediu ◽  
...  
Keyword(s):  
Clinical Decision Making ◽  
Point Of Care ◽  
Low Cost ◽  
Diagnostic Testing ◽  
Clinical Decision ◽  
Rapid Screening ◽  
Diagnostic Tools ◽  
Point Of Care Testing ◽  
Qrt Pcr ◽  
User Friendly

The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the “gold standard” involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis.

Point-of-Care Systems for Rapid DNA Quantification in Oncology

2008 ◽  
Vol 94 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Marco Bianchessi ◽  
Sarah Burgarella ◽  
Marco Cereda
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Semiconductor Industry ◽  
Point Of Care Testing ◽  
Lab On Chip ◽  
Diagnostic Assays ◽  
Care Systems ◽  
Point Of Care Systems ◽  
The Common ◽  
On Chip

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.

Integrated point of care testing system based on low cost polymer biochips

2009 ◽  
Author(s):  
Albrecht Brandenburg ◽  
Franziska Curdt ◽  
Joerg Nestler ◽  
Thomas Otto ◽  
Kai Wunderlich ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Testing System ◽  
Point Of Care Testing

Low-Cost Microdevices for Point-of-Care Testing

2012 ◽  
pp. 3-21 ◽  
Author(s):  
Curtis D. Chin ◽  
Sau Yin Chin ◽  
Tassaneewan Laksanasopin ◽  
Samuel K. Sia
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Point Of Care Testing

scholarly journals Improved assessment of accuracy and performance indicators in paper-based ELISA

2017 ◽  
Vol 9 (18) ◽  
pp. 2644-2653 ◽  
Author(s):  
Thiago Mazzu-Nascimento ◽  
Giorgio Gianini Morbioli ◽  
Luis Aparecido Milan ◽  
Diego Furtado Silva ◽  
Fabiana Cristina Donofrio ◽  
...  
Keyword(s):  
Performance Indicators ◽  
Point Of Care ◽  
Low Cost ◽  
Point Of Care Testing ◽  
And Performance

Paper-based devices are an excellent match for low-cost point-of-care testing (POCT) tools.

scholarly journals Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Sensors ◽  
2020 ◽  
Vol 20 (21) ◽  
pp. 6073
Author(s):  
Chunyang Lu ◽  
Jintao Han ◽  
Xiaoyi Sun ◽  
Gen Yang
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Electrochemical Method ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Point Of Care Testing ◽  
Testing Instrument ◽  
The Past ◽  
Main Target

Circulating tumor cells (CTCs) are tumor cells that escaped from the primary tumor or the metastasis into the blood and they play a major role in the initiation of metastasis and tumor recurrence. Thus, it is widely accepted that CTC is the main target of liquid biopsy. In the past few decades, the separation of CTC based on the electrochemical method has attracted widespread attention due to its convenience, rapidness, low cost, high sensitivity, and no need for complex instruments and equipment. At present, CTC detection is not widely used in the clinic due to various reasons. Point-of-care CTC detection provides us with a possibility, which is sensitive, fast, cheap, and easy to operate. More importantly, the testing instrument is small and portable, and the testing does not require specialized laboratories and specialized clinical examiners. In this review, we summarized the latest developments in the electrochemical-based CTC detection and point-of-care CTC detection, and discussed the challenges and possible trends.

scholarly journals A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors

Lab on a Chip ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 1051-1059 ◽  
Author(s):  
Andrew S. Paterson ◽  
Balakrishnan Raja ◽  
Vinay Mandadi ◽  
Blane Townsend ◽  
Miles Lee ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Test Strip ◽  
Lateral Flow ◽  
Point Of Care Testing ◽  
Flow Test ◽  
Highly Sensitive ◽  
Lateral Flow Test ◽  
Gated Imaging

Time-gated imaging on a smartphone of a lateral flow test strip run with persistent luminescent nanophosphors.

A three-dimensional origami-based immuno-biofuel cell for self-powered, low-cost, and sensitive point-of-care testing

2014 ◽  
Vol 50 (16) ◽  
pp. 1947 ◽  
Author(s):  
Yanhu Wang ◽  
Lei Ge ◽  
Panpan Wang ◽  
Mei Yan ◽  
Jinghua Yu ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Three Dimensional ◽  
Biofuel Cell ◽  
Point Of Care Testing ◽  
Self Powered

Current Point-of-Care testing in cancer and future perspectives: a systematic review

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
M Rodrigues ◽  
I Andrade ◽  
R Cruz
Keyword(s):  
Systematic Review ◽  
Early Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Rapid Test ◽  
Point Of Care Testing ◽  
Screening Programs ◽  
Low Resource ◽  
Resource Limited ◽  
Prevalent Disease

Abstract Introduction Cancer is the most prevalent disease worldwide, causing a major impact on society. Early detection and monitorization of the tumour can provide a more effective treatment. Point-of-care (POC) testing allows the patient to have a handheld test that gives the results rapidly. No expertise or special knowledge is required which is vital namely when carried out in low-resource areas. Recent studies analysed established and emerging biomarkers and how to incorporate them into POC devices, but a systematic review reporting the existing POC platforms for cancer is still not available. Objectives This systematic review aims to report current and recent advances for point-of-care testing in cancer. Methodology A literature review was conducted through research in the databases “PubMed” and “B-On” for relevant reviews published in the last ten years, using the keywords “Point-of-care testing” AND “Cancer” AND “Rapid Test” AND “Cancer detection”. Results In 2015 there were eight commercially available POC tests for prostate, bladder, colorectal, cervical, HPV-causing head and neck cancer, liver, breast and lung cancer. After 2018 a small number of POC devices were tested in screening programs and multicentric studies, and more recently, promising novel POC prototypes for early detection of cancer, namely a 3D prototype micro device for multiple singleplex RNA expression analysis in liver cancer and a POC microscopy prototype for digital diagnostics of breast cancer lymph node metastases, with potential to be used in resource-limited settings. Conclusion The use of POC testing can deliver accurate, fast results, and in the case of cancer it is no exception, contributing to the progression of treatment and reduction in cancer-related deaths. In low-resource settings a POC test is fundamental and it should be simple and low-cost. But there are limitations in the tests which is a challenge for improvement and investigation in the future.

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