scholarly journals Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis

The Analyst ◽  
2013 ◽  
Vol 138 (22) ◽  
pp. 6986 ◽  
Author(s):  
Yogesh M. Kulkarni ◽  
Changxing Liu ◽  
Qi Qi ◽  
Yanmei Zhu ◽  
David J. Klinke II ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Caveolin 1 ◽  
Potential Mediator ◽  
Interaction Partners ◽  
Induced Apoptosis

scholarly journals Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Qingqiang Xu ◽  
Wenwen Shi ◽  
Pan Lv ◽  
Wenqi Meng ◽  
Guanchao Mao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Aflatoxin B1 ◽  
Cell Apoptosis ◽  
Critical Role ◽  
Hepatic Cell ◽  
Hepatocellular Injury ◽  
Caveolin 1 ◽  
Induced Apoptosis

AbstractAflatoxin B1 (AFB1) is a potent hepatocarcinogen in humans and exposure to AFB1 is known to cause both acute and chronic hepatocellular injury. As the liver is known to be the main target organ of aflatoxin, it is important to identify the key molecules that participate in AFB1-induced hepatotoxicity and to investigate their underlying mechanisms. In this study, the critical role of caveolin-1 in AFB1-induced hepatic cell apoptosis was examined. We found a decrease in cell viability and an increase in oxidation and apoptosis in human hepatocyte L02 cells after AFB1 exposure. In addition, the intracellular expression of caveolin-1 was increased in response to AFB1 treatment. Downregulation of caveolin-1 significantly alleviated AFB1-induced apoptosis and decreased cell viability, whereas overexpression of caveolin-1 reversed these effects. Further functional analysis showed that caveolin-1 participates in AFB1-induced oxidative stress through its interaction with Nrf2, leading to the downregulation of cellular antioxidant enzymes and the promotion of oxidative stress-induced apoptosis. In addition, caveolin-1 was found to regulate AFB1-induced autophagy. This finding was supported by the effect that caveolin-1 deficiency promoted autophagy after AFB1 treatment, leading to the inhibition of apoptosis, whereas overexpression of caveolin-1 inhibited autophagy and accelerated apoptosis. Interestingly, further investigation showed that caveolin-1 participates in AFB1-induced autophagy by regulating the EGFR/PI3K-AKT/mTOR signaling pathway. Taken together, our data reveal that caveolin-1 plays a crucial role in AFB1-induced hepatic cell apoptosis via the regulation of oxidation and autophagy, which provides a potential target for the development of novel treatments to combat AFB1 hepatotoxicity.

Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells

BioMetals ◽  
2010 ◽  
Vol 23 (6) ◽  
pp. 1179-1189 ◽  
Author(s):  
Liming Shen ◽  
Ziyao Lan ◽  
Xiaohong Sun ◽  
Lei Shi ◽  
Qiong Liu ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Proteomic Analysis ◽  
Human Cervical Carcinoma ◽  
Siha Cells ◽  
Induced Apoptosis

scholarly journals MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 24314-24326 ◽  
Author(s):  
Qingmei Kang ◽  
Yue Xiang ◽  
Dan Li ◽  
Jie Liang ◽  
Xiong Zhang ◽  
...  
Keyword(s):  
Tau Protein ◽  
Caveolin 1 ◽  
Induced Apoptosis

Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis

APOPTOSIS ◽  
2013 ◽  
Vol 18 (11) ◽  
pp. 1291-1305 ◽  
Author(s):  
Ibrahim Alanazi ◽  
Esmaeil Ebrahimie ◽  
Peter Hoffmann ◽  
David L. Adelson
Keyword(s):  
Gene Expression ◽  
Proteomic Analysis ◽  
A431 Cells ◽  
Induced Apoptosis

scholarly journals Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells

2014 ◽  
Vol 32 (1) ◽  
pp. 293-301 ◽  
Author(s):  
WEI MA ◽  
DI-DI WANG ◽  
LI LI ◽  
YU-KUAN FENG ◽  
HONG-MEI GU ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Caveolin 1 ◽  
Induced Apoptosis

Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line

2006 ◽  
Vol 25 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Marta Monge ◽  
Marta Vilaseca ◽  
Vanessa Soto-Cerrato ◽  
Beatriz Montaner ◽  
Ernest Giralt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Proteomic Analysis ◽  
Induced Apoptosis ◽  
Mcf 7

Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells

2009 ◽  
Vol 378 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Xiangxuan Zhao ◽  
Yong Liu ◽  
Qi Ma ◽  
Xiaohui Wang ◽  
Haijing Jin ◽  
...  
Keyword(s):  
Caveolin 1 ◽  
Hepatocarcinoma Cells ◽  
Induced Apoptosis ◽  
Human Hepatocarcinoma Cells
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