A novel lysine-protecting procedure for continuous flow solid phase synthesis of branched peptides

1993 ◽  
pp. 778 ◽  
Author(s):  
Barrie W. Bycroft ◽  
Weng C. Chan ◽  
Siri Ram Chhabra ◽  
Neal D. Hone
Keyword(s):  
Continuous Flow ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Branched Peptides

scholarly journals The Breaking Beads Approach for Photocleavage from Solid Support

2020 ◽  
Author(s):  
yasmeen bakhatan ◽  
Israel Alshanski ◽  
Dana Grunhaus ◽  
Mattan Hurevich
Keyword(s):  
Continuous Flow ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
High Energy ◽  
Solid Support ◽  
Phase Synthesis ◽  
Polystyrene Beads ◽  
Magnetic Stirring ◽  
Photolabile Linkers

Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. The photocleavage, usually performed by batch irradiation, suffers from incomplete and slow cleavage. To overcome these issues, continuous flow and high-energy lamps are frequently used, but these setups are hazardous, technically challenging, and expensive. We developed a photocleavage approach that relies on a benchtop LED lamp and magnetic stirring. In this approach, we crush the beads instead of keeping their integrity to increase the yield of photocleavage. This approach proved very efficient for photocleavage of protected oligosaccharides.

scholarly journals Solid Phase Synthesis of a 31-Residue Fragment of Human Glucose-Dependent Insulinotropic Polypeptide (GIP) by the Continuous Flow Polyamide Method.

1987 ◽  
Vol 41b ◽  
pp. 494-498 ◽  
Author(s):  
Mats Carlquist ◽  
Jon Erik Brænden ◽  
Yngve Stenstrøm ◽  
Arne Jørgen Aasen ◽  
G. W. Fischer
Keyword(s):  
Continuous Flow ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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