New syntheses of C-mercuriated sugars and rapid conversion into bromo-sugars by reaction with bromine chloride from sodium bromide and chloramine-T

ChemInform Abstract: NEW SYNTHESES OF C-MERCURATED SUGARS AND RAPID CONVERSION INTO BROMO SUGARS BY REACTION WITH BROMINE CHLORIDE FROM SODIUM BROMIDE AND CHLORAMINE-T

Chemischer Informationsdienst ◽

10.1002/chin.198252338 ◽

1982 ◽

Vol 13 (52) ◽

Author(s):

L. D. HALL ◽

J.-R. NEESER

Keyword(s):

Sodium Bromide ◽

Bromine Chloride ◽

Chloramine T ◽

Rapid Conversion

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Fast, mild, and convenient procedures for iodination and bromination of carbohydrates: reactions of organoboranes with iodine monochloride, sodium iodide, bromine, and bromine chloride

Canadian Journal of Chemistry ◽

10.1139/v82-296 ◽

1982 ◽

Vol 60 (16) ◽

pp. 2082-2086 ◽

Cited By ~ 9

Author(s):

Laurance D. Hall ◽

Jean-Richard Neeser

Keyword(s):

Good Yield ◽

Sodium Iodide ◽

Starting Material ◽

Iodine Monochloride ◽

Bromine Chloride ◽

Chloramine T

5,6-Dideoxy-1,2-O-isopropylidene-3-O-methanesulfonyl-α-D-xlyo-hexofuranosene-5 (1), reacts with BH3–THF to form the tris(glycosyl)borane (2) and with dicyclohexylborane to form the dicyclohexylglycosylborane (3). The iodination and bromination of 2 and 3 has been investigated using a variety of electrophiles. Iodination of either 2 or 3 with NaI–Chloramine-T/NaOAc is complete within one minute with high percentage uptake of iodine (70–90%) and recovery of the iodinated sugar (4). Bromination of 2 in 15 minutes with NaBr–Chloramine-T permits a high percentage uptake of bromine (75%), and bromination of 3 in 15 minutes with Br2/NaOAc gives the brominated sugar (5) with a reasonably good yield (60%) with respect to the starting material (1).

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Catabolism of Human Fibrinogen Fragment D in Normal Subjects and Patients with Liver Cirrhosis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650106 ◽

1980 ◽

Vol 44 (03) ◽

pp. 146-149 ◽

Cited By ~ 3

Author(s):

Nicole Ardaillou ◽

Jeannine Yvart ◽

Philippe Le Bras ◽

Marie-José Larrieu

Keyword(s):

Liver Cirrhosis ◽

Clearance Rate ◽

Plasma Clearance ◽

Normal Subjects ◽

Fractional Catabolic Rate ◽

Human Fibrinogen ◽

Plasma Pool ◽

Catabolic Rate ◽

Chloramine T

SummaryThe catabolism of human fragment D, (FgD), obtained by plasmin digestion of fibrinogen has been investigated in normal subjects and patients with liver cirrhosis and the results compared with those obtained for fibrinogen (Fg). Fg was labelled with I-125 and Fg D with I-131 using the chloramine T method. The plasma disappearance curves of both labelled proteins fitted a two exponential curve. In controls the plasma clearance rate of Fg D was greater than that of Fg as shown by the marked difference between the half-lives of these two tracers: 8,9 and 83,5 hours for Fg D and Fg respectively. The fractional catabolic rate of Fg D was 3.38 times the plasma pool per day. In nine patients with liver cirrhosis, catabolism of Fg was not modified. In contrast, catabolism of Fg D was significantly reduced with a half life of 13.0 hours and a low fractional catabolic rate. These results suggest the role of the liver in the catabolism of Fg D in man.

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