Optically active trifluoromethylcarbinols as chiral solvating agents for asymmetric transformations at a ring-nitrogen atom

1981 ◽  
pp. 588 ◽  
Author(s):  
Arrigo Forni ◽  
Irene Moretti ◽  
Alexandr V. Prosyanik ◽  
Giovanni Torre
Keyword(s):  
Nitrogen Atom ◽  
Optically Active ◽  
Asymmetric Transformations ◽  
Ring Nitrogen ◽  
Ring Nitrogen Atom

Übergangsmetallkomplexe mit Nitroxidradikalen: Palladium-, Platin-, Pentamethylcyclopentadienyl-rhodium- und -iridium-Komplexe sowie α-Aminocarboxylatkomplexe mit Donor-haltigen Derivaten des 2,5-Dihydroimidazol-l-oxyls / Transition Metal Complexes of Nitroxide Radicals, Palladium, Platinum, Pentamethylcyclopentadienyl Rhodium and Iridium Complexes, and α-Aminocarboxylate Complexes with Derivatives of 2,5-Dihydroimidazole-l-oxyls

1998 ◽  
Vol 53 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Frank Hintermaier ◽  
Sylvia Helding ◽  
Leonid B. Volodarsky ◽  
Karlheinz Sünkel ◽  
Kurt Polbom ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Molecular Structures ◽  
Iridium Complexes ◽  
X Ray Diffraction ◽  
Chelate Complexes ◽  
X Ray ◽  
Ring Nitrogen ◽  
Derivatives Of ◽  
Ring Nitrogen Atom ◽  
Palladium Platinum

2,5-Dihydroimidazoline-l-oxyl radicals I, II with imino substituents coordinate to Pd(II) and Pt(II) complexes with formation of the N,N chelate complexes 1-6. With oxygen containing substituents either monodentate N-coordination to give 8 or N ,O chelate formation to give 9 takes place, depending on the position of the oxygen atom relative to the ring nitrogen atom. With radicals III that also have the second ring nitrogen atom oxidized and the Rh(III) or Ir(III) complexes [Cp*MCl2]2 the O , O chelates 11 -13 could be obtained, while with Na2PdCl4 the heterocycle was destroyed with formation of a N,N chelate complex 10 of an α-nitrosooxime ligand. The orthopalladated 2,2,5,5 tetramethyl-4-phenyl-2,5-dihydroimidazoline-l-oxyl complex 7a reacts with several a-amino acidates under splitting of the dichloro bridge with formation of the C,N/N,O-bis-chelate complexes 7b-f. The molecular structures of 2 and 10 were determined by X-ray diffraction.

scholarly journals Exploring the Isomer Dependent SERS Spectra of (diphenylphosphoryl)(pyridin-2, -3, and -4-yl)methanol Adsorbed on Gold Nanocolloids

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Pięta ◽  
Edyta Proniewicz ◽  
Bogdan Boduszek ◽  
Tomasz K. Olszewski ◽  
Younkyoo Kim ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Adsorption Process ◽  
Gold Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Ring Nitrogen ◽  
Derivatives Of ◽  
Ring Nitrogen Atom ◽  
Surface Changes

The surface-enhanced Raman scattering (SERS) spectra of three aminophosphonate derivatives of pyridine: (diphenylphosphoryl)(pyridin-2-yl)methanol (α-Pyr), (diphenylphosphoryl)(pyridin-3-yl)methanol (β-Pyr), and (diphenylphosphoryl)(pyridin-4-yl)methanol (γ-Pyr) were measured after immobilization onto colloidal gold surface. Changes in the wavenumber, broadness, and enhancement between the corresponding Raman and SERS bands allowed to deduce orientation of theα-,β-, andγ-isomers (α-,β-, andγ-refer to the position of the substituent relative to the ring nitrogen atom) of aminophosphonate derivatives of pyridine on the gold surface. Briefly, it was demonstrated that theα-Pyr andβ-Pyr show the same mode of adsorption, whereas the adsorption process of theγ-Pyr isomer differs in this regard that pyridine assists in the interaction with the gold surface.

Relationships between immunogen structure and antisera specificity in the narcotic alkaloid series.

1981 ◽  
Vol 27 (9) ◽  
pp. 1524-1535 ◽  
Author(s):  
J W Findlay ◽  
R F Butz ◽  
E C Jones
Keyword(s):  
Solvent Extraction ◽  
Nitrogen Atom ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Structural Changes ◽  
Piperidine Ring ◽  
Specific Antisera ◽  
Ring Nitrogen ◽  
Ring Nitrogen Atom

Abstract We report the production and comparative specificities of antisera raised to different immunogens containing codeine, morphine, and oxycodone. Antisera raised to bovine serum albumin (BSA) conjugates of codeine-6-hemisuccinate, ethylmorphine-6-hemisuccinate, or oxycodone-6-carboxymethyloxime had greatest recognition of structural changes around the piperidine ring nitrogen atom and th 14-position. N-carboxypropylnormorphine-BSA, N-carboxypropylnorcodeine-BSA, and norcodeine-BSA (directly coupled) conjugates elicited antisera that recognized structural changes at the 3- and 6-positions best, but also clearly discerned changes in the 14-substituent. Attachment of codeine to BSA via the 8-position gave a conjugate that elicited antisera with specificity characteristics similar to those of the antiserum to N-carboxypropylnorcodeine-BSA. Thus clear relationships existed between immunogen structure and antiserum specificity. The utility of these antisera was illustrated by the application of antiserum to codeine-6-hemisuccinate-BSA and solvent extraction to a study of codeine disposition in the dog. The specific antisera of N-carboxypropylnormorphine-BSA and to norcodeine-BSA were applied directly to an examination of the distribution of codeine and metabolically produced morphine in the milk and plasma of a nursing mother.

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