Structure elucidation of MM 17880, a new fused β-lactam antibiotic isolated from Streptomyces olivaceus; a mild β-lactam degradation reaction

1977 ◽  
Vol 0 (24) ◽  
pp. 953-954 ◽  
Author(s):  
David F. Corbett ◽  
A. John Eglington ◽  
T. Trefor Howarth
Keyword(s):  
Structure Elucidation ◽  
Lactam Antibiotic ◽  
Degradation Reaction ◽  
Streptomyces Olivaceus

ChemInform Abstract: Kanchanamycins, New Polyol Macrolide Antibiotics Produced by Streptomyces olivaceus Tue 4018. Part 2. Structure Elucidation.

ChemInform ◽  
2010 ◽  
Vol 28 (6) ◽  
pp. no-no
Author(s):  
H. STEPHAN ◽  
C. KEMPTER ◽  
J. W. METZGER ◽  
G. JUNG ◽  
O. POTTERAT ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Macrolide Antibiotics ◽  
Streptomyces Olivaceus

scholarly journals Kanchanamycins, New Polyol Macrolide Antibiotics Produced by Streptomyces olivaceus Tue 4018. II. Structure Elucidation.

1996 ◽  
Vol 49 (8) ◽  
pp. 765-769 ◽  
Author(s):  
HOLGER STEPHAN ◽  
CHRISTOPH KEMPTER ◽  
JÖRG W. METZGER ◽  
GÜNTHER JUNG ◽  
OLIVIER POTTERAT ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Macrolide Antibiotics ◽  
Streptomyces Olivaceus

Effect of piperacillin on morphology and viability of gram-negative bacteria

1984 ◽  
Vol 42 ◽  
pp. 218-219
Author(s):  
R. H. Liss
Keyword(s):  
Inhibitory Concentration ◽  
Cytoplasmic Membrane ◽  
Drug Binding ◽  
Gram Negative Bacteria ◽  
Bacterial Cells ◽  
Drug Induced ◽  
Penicillin Binding Proteins ◽  
Lactam Antibiotic ◽  
Drug Free ◽  
Tube Dilution

Piperacillip (PIP) is b-[D(-)-α-(4-ethy1-2,3-dioxo-l-piperzinylcar-bonylamino)-α-phenylacetamido]-penicillanate. The broad spectrum semisynthetic β-lactam antibiotic is believed to effect bactericidal activity through its affinity for penicillin-binding proteins (PBPs), enzymes on the bacterial cytoplasmic membrane that control elongation and septation during cell growth and division. The purpose of this study was to correlate penetration and binding of 14C-PIP in bacterial cells with drug-induced lethal changes assessed by microscopic, microbiologic and biochemical methods.The bacteria used were clinical isolates of Escherichia coli and Pseudomonas aeruginosa (Figure 1). Sensitivity to the drug was determined by serial tube dilution in Trypticase Soy Broth (BBL) at an inoculum of 104 organisms/ml; the minimum inhibitory concentration of piperacillin for both bacteria was 1 μg/ml. To assess drug binding to PBPs, the bacteria were incubated with 14C-PIP (5 μg/0.09 μCi/ml); controls, in drug-free medium.

Isolation of isoflavonoids from Amphimas pterocarpoides and structure elucidation using LC-HRMSn and NMR techniques

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Tchoumtchoua ◽  
M Halabalaki ◽  
D Njamen ◽  
J Mbanya ◽  
L Skaltsounis
Keyword(s):  
Structure Elucidation ◽  
Nmr Techniques

New rare atropisomers: structure elucidation, absolute configuration and antimicrobial activity

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Debbab ◽  
R Bara ◽  
A Pretsch ◽  
R Edrada Ebel ◽  
V Wray ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Absolute Configuration ◽  
Structure Elucidation
Sign in / Sign up

Export Citation Format

Share Document