ChemInform Abstract: STRUCTURE ELUCIDATION AND SYNTHESIS OF (2S)-4-OXO-1-AZABICYCLO(3.3.0)OCTA-5,7-DIENE-2-CARBOXYLIC ACID, A NEW METABOLITE ISOLATED FROM STREPTOMYCES OLIVACEUS

1982 ◽  
Vol 13 (3) ◽  
Author(s):  
S. J. BOX ◽  
D. F. CORBETT
Keyword(s):  
Carboxylic Acid ◽  
Structure Elucidation ◽  
Abstract Structure ◽  
Streptomyces Olivaceus

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

ChemInform Abstract: Structure Elucidation of a Glycopeptide Antibiotic, OA-7653.

ChemInform ◽  
1988 ◽  
Vol 19 (44) ◽  
Author(s):  
S.-G. ANG ◽  
M. P. WILLIAMSON ◽  
D. H. WILLIAMS
Keyword(s):  
Structure Elucidation ◽  
Glycopeptide Antibiotic ◽  
Abstract Structure

Synthesis of Optically Active Hydroxyalkyl Cycloheptatrienes: A Key Step in the Total Synthesis of 6,11-Methylene-LXB4

Synlett ◽  
2020 ◽  
Vol 32 (01) ◽  
pp. 45-50
Author(s):  
Udo Nubbemeyer ◽  
Analuisa Nava ◽  
Lukas Trippe ◽  
Andrea Frank ◽  
Lars Andernach ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Total Synthesis ◽  
Structure Elucidation ◽  
Butyl Ester ◽  
Optically Active ◽  
Chiral Hplc ◽  
Reaction Conditions ◽  
Acid Product ◽  
Tert Butyl ◽  
Nabh4 Reduction

AbstractStarting from methyl cycloheptatrienyl-1-carboxylate, 6-acylation was successfully achieved employing glutaryl chloride in the presence of AlCl3 under controlled reaction conditions to furnish keto carboxylic acid product. After protection of this keto carboxylic acid as tert-butyl ester, reagent-controlled enantioselective reductions delivered configuration-defined methyl-6-hydroxylalkyl cycloheptatriene-1-carboxylates with up to 80% ee. Whereas simple NaBH4 reduction of the keto carboxylic acid and subsequent lactonization afforded a methyl-6-tetrahydropyranonyl cycloheptatriene-1-carboxylate. Resolution using chiral HPLC delivered the product enantiomers with up to >99% ee Finally, ECD analyses enabled structure elucidation. The products are used as key intermediates in enantioselective 6,11-methylene-lipoxin B4 syntheses.

2,3,9-Trihydroxyphenazin-l-carbonsäure – ein unter Berylliumeinwirkung gebildetes neues Phenazinderivat aus Pseudomonas fluorescens [1] / 2,3,9-Trihydroxyphenazine- l -carboxylic Acid — a New Phenazine Derivative from Pseudomonas fluorescens Grown under Beryllium Stress [1]

1990 ◽  
Vol 45 (4) ◽  
pp. 552-556 ◽  
Author(s):  
K. Taraz ◽  
E. M. Schaffner ◽  
H. Budzikiewicz ◽  
H. Korth ◽  
G. Pulverer
Keyword(s):  
Carboxylic Acid ◽  
Iron Deficiency ◽  
Dicarboxylic Acid ◽  
Pseudomonas Fluorescens ◽  
Structure Elucidation ◽  
Culture Medium ◽  
Phenazine Derivative

In addition to phenazine, phenazine-1-carboxylic acid, phenazine-1,6-dicarboxylic acid and 2,9-dihydroxyphenazine-1-carboxylic acid a new compound, viz. 2,3,9-trihydroxyphenazine-1-carboxylic acid could be isolated from the culture medium of Pseudomonas fluorescens grown under iron deficiency with beryllium added to the culture medium. Its structure elucidation is described.

ChemInform Abstract: STRUCTURE ELUCIDATION OF A POTENT MUTAGEN FROM HUMAN FECES

1983 ◽  
Vol 14 (5) ◽  
Author(s):  
N. HIRAI ◽  
D. G. I. KINGSTON ◽  
R. L. VAN TASSELL ◽  
T. D. WILKINS
Keyword(s):  
Structure Elucidation ◽  
Human Feces ◽  
Abstract Structure

ChemInform Abstract: Structure Elucidation of a New Neutral Macrolide Antibiotic (I).

ChemInform ◽  
1987 ◽  
Vol 18 (7) ◽  
Author(s):  
J. R. HAUSKE ◽  
J. DIBRINO ◽  
M. GUADLIANA ◽  
G. KOSTEK
Keyword(s):  
Structure Elucidation ◽  
Macrolide Antibiotic ◽  
Abstract Structure
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