Multiple stimuli-responsive polymeric micelles for controlled release

Soft Matter ◽  
2013 ◽  
Vol 9 (2) ◽  
pp. 370-373 ◽  
Author(s):  
Jie Dong ◽  
Yani Wang ◽  
Jian Zhang ◽  
Xiaowei Zhan ◽  
Siquan Zhu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymeric Micelles ◽  
Stimuli Responsive

scholarly journals Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 176 ◽  
Author(s):  
Yongle Luo ◽  
Xujun Yin ◽  
Xi Yin ◽  
Anqi Chen ◽  
Lili Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Drug ◽  
Diblock Copolymers ◽  
Polymeric Micelles ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Amino Esters ◽  
Redox Responsive ◽  
Poly Ethylene

Stimuli-responsive polymeric micelles (PMs) have shown great potential in drug delivery and controlled release in cancer chemotherapy. Herein, inspired by the features of the tumor microenvironment, we developed dual pH/redox-responsive mixed PMs which are self-assembled from two kinds of amphiphilic diblock copolymers (poly(ethylene glycol) methyl ether-b-poly(β-amino esters) (mPEG-b-PAE) and poly(ethylene glycol) methyl ether-grafted disulfide-poly(β-amino esters) (PAE-ss-mPEG)) for anticancer drug delivery and controlled release. The co-micellization of two copolymers is evaluated by measurement of critical micelle concentration (CMC) values at different ratios of the two copolymers. The pH/redox-responsiveness of PMs is thoroughly investigated by measurement of base dissociation constant (pKb) value, particle size, and zeta-potential in different conditions. The PMs can encapsulate doxorubicin (DOX) efficiently, with high drug-loading efficacy. The DOX was released due to the swelling and disassembly of nanoparticles triggered by low pH and high glutathione (GSH) concentrations in tumor cells. The in vitro results demonstrated that drug release rate and cumulative release are obviously dependent on pH values and reducing agents. Furthermore, the cytotoxicity test showed that the mixed PMs have negligible toxicity, whereas the DOX-loaded mixed PMs exhibit high cytotoxicity for HepG2 cells. Therefore, the results demonstrate that the dual pH/redox-responsive PMs self-assembled from PAE-based diblock copolymers could be potential anticancer drug delivery carriers with pH/redox-triggered drug release, and the fabrication of stimuli-responsive mixed PMs could be an efficient strategy for preparation of intelligent drug delivery platform for disease therapy.

scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

Triple-stimuli-responsive nanocontainers assembled by water-soluble pillar[5]arene-based pseudorotaxanes for controlled release

2016 ◽  
Vol 4 (16) ◽  
pp. 2819-2827 ◽  
Author(s):  
ChenDi Ding ◽  
Ying Liu ◽  
Ting Wang ◽  
JiaJun Fu
Keyword(s):  
Controlled Release ◽  
Water Soluble ◽  
Stimuli Responsive ◽  
Working Mechanism

Working mechanism of triple-stimuli-responsive nanocontainers: alkaline, acid and Zn2+ stimuli can open the advanced supramolecular nanovalves.

scholarly journals Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments

2021 ◽  
Author(s):  
Maksymilian Marek Zegota ◽  
Michael Andreas Müller ◽  
Bellinda Lantzberg ◽  
Gönül Kizilsavas ◽  
Jaime A. S. Coelho ◽  
...  
Keyword(s):  
Controlled Release ◽  
Stimuli Responsive ◽  
Peptide Tags

Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform

2018 ◽  
Vol 6 (42) ◽  
pp. 6817-6830 ◽  
Author(s):  
Wen Liu ◽  
Jian Dai ◽  
Wei Xue
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Target Sites

Stimuli-responsive nanomaterial-based drug delivery systems that are able to actively target the tumor microenvironment, enhance intratumoral accumulation and release drugs at target sites are attractive therapeutic platforms at present.

Controlled release of N-(2-hydroxyphenyl)-2-propylpentanamide nanoencapsulated in polymeric micelles of P123 and F127 tested as anti-proliferative agents in MDA-MB-231 cells

2018 ◽  
Vol 48 ◽  
pp. 403-413 ◽  
Author(s):  
Xelhua Marcos ◽  
Cynthia Padilla-Beltrán ◽  
María Josefa Bernad-Bernad ◽  
Martha Cecilia Rosales-Hernández ◽  
Silvia Pérez-Casas ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymeric Micelles
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