scholarly journals The mechanical properties of amniotic membrane influence its effect as a biomaterial for ocular surface repair

Soft Matter ◽  
2012 ◽  
Vol 8 (32) ◽  
pp. 8379 ◽  
Author(s):  
Bo Chen ◽  
Roanne R. Jones ◽  
Shengli Mi ◽  
James Foster ◽  
Simon G. Alcock ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Amniotic Membrane ◽  
Ocular Surface ◽  
Surface Repair ◽  
Ocular Surface Repair

Polyphosphate, the physiological metabolic fuel for corneal cells: a potential biomaterial for ocular surface repair

2019 ◽  
Vol 7 (12) ◽  
pp. 5506-5515 ◽  
Author(s):  
Xiaohong Wang ◽  
Adrian Gericke ◽  
Maximilian Ackermann ◽  
Shunfeng Wang ◽  
Meik Neufurth ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Ocular Surface ◽  
Inorganic Polymer ◽  
Metabolic Fuel ◽  
Corneal Cells ◽  
And Migration ◽  
Surface Repair ◽  
Proliferation And Migration ◽  
Ocular Surface Repair

Polyphosphate, a natural inorganic polymer that acts as a reservoir for metabolic fuel (ATP), increases the proliferation and migration potency of epithelial cells, covering the avascular cornea.

Ocular Surface Repair Using Decellularized Porcine Conjunctiva

2019 ◽  
Author(s):  
Long Zhao ◽  
Yanni Jia ◽  
Can Zhao ◽  
Ting Liu ◽  
Songmei Zhang ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Surface Repair ◽  
Ocular Surface Repair

Ocular surface repair using decellularized porcine conjunctiva

2020 ◽  
Vol 101 ◽  
pp. 344-356 ◽  
Author(s):  
Long Zhao ◽  
Yanni Jia ◽  
Can Zhao ◽  
Hua Li ◽  
Fuyan Wang ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Surface Repair ◽  
Ocular Surface Repair

Mesenchymal stromal cells for ocular surface repair

2019 ◽  
Vol 19 (7) ◽  
pp. 643-653 ◽  
Author(s):  
Olla Al-Jaibaji ◽  
Stephen Swioklo ◽  
Che J. Connon
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Ocular Surface ◽  
Surface Repair ◽  
Ocular Surface Repair

scholarly journals Development of biomimetic materials for sutureless ocular surface repair

2016 ◽  
Vol 4 ◽  
Author(s):  
Costella Lauren ◽  
Eiseman Andrew ◽  
Redmond Robert ◽  
Tison Christopher
Keyword(s):  
Ocular Surface ◽  
Biomimetic Materials ◽  
Surface Repair ◽  
Ocular Surface Repair

Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice

2021 ◽  
Author(s):  
Noelia Sabater-Cruz ◽  
◽  
Marc Figueras-Roca ◽  
Miriam Ferrán-Fuertes ◽  
Elba Agustí ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Amniotic Membrane ◽  
Real World ◽  
Ocular Surface ◽  
Eye Drops ◽  
Ocular Surface Diseases ◽  
Membrane Extract

scholarly journals Nano-Scale Modifications of Amniotic Membrane Induced by UV and Antibiotic Treatment: Histological, AFM and FTIR Spectroscopy Evidence

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 863
Author(s):  
Simona Cavalu ◽  
George Roiu ◽  
Ovidiu Pop ◽  
Denisa A. Petricas Heredea ◽  
Traian Octavian Costea ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Antibiotic Treatment ◽  
Amniotic Membrane ◽  
Ocular Surface ◽  
Enzymatic Digestion ◽  
Uv Exposure ◽  
Amniotic Membrane Transplantation ◽  
Corneal Tissue ◽  
Nano Scale ◽  
Gentamicin Treatment

The efficiency of amniotic membrane (AM) transplantation in different types of ocular surface disorders is due to its outstanding properties such as antifibrotic, antibacterial, anti-inflammatory and antiangiogenic, working as a versatile scaffold to promote corneal tissue epithelialization. A proper preparation, preservation and clinical application are crucial for the best outcomes in the treatment of different severe ocular disorders, taking into account its fragility. In this context, by combining high-sensitivity tools such as atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy with histological and immunohistochemical examination, we aimed to investigate the ultrastructural modifications of the amniotic membrane (AM) upon UV exposure and/or antibiotic treatment, with relevance for clinical applications in ocular surface surgery. From the morphological point of view, we noticed a loss of cuboidal cells in the basal membrane, accompanied by the splitting of collagen fibers upon UV and/or gentamicin treatment, while structural alteration of proteins was evidenced by the FTIR quantitative analysis of the secondary structure. A decrease in α-helix and β-sheet content, accompanied by increased content in less ordered structures (turns, random and side chains), was noticed after all the treatments. At the nano-scale, AFM details showed modifications of collagen fibrils in terms of their thickness and network compaction upon gentamicin and/or UV treatment. The enzymatic digestion assay demonstrated that UV exposure significantly reduces the degradation rate of the AM, while gentamicin treatment promotes an accelerated enzymatic digestion upon UV exposure. In order to highlight the clinical impact of the research, a clinical case is presented showing the relevance of amniotic membrane transplantation in pterygium surgery.

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