Exploiting conformationally restricted N,N′-dimethyl-N,N′-diarylureas as biologically active CC double bond analogues: synthesis and biological evaluation of combretastatin A-4 analogues

RSC Advances ◽  
2012 ◽  
Vol 2 (19) ◽  
pp. 7557 ◽  
Author(s):  
Timothy J. Snape ◽  
Katherine Karakoula ◽  
Farzana Rowther ◽  
Tracy Warr
Keyword(s):  
Double Bond ◽  
Biological Evaluation ◽  
Biologically Active ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues

MedChemComm ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 1445-1456 ◽  
Author(s):  
Casey J. Maguire ◽  
Graham J. Carlson ◽  
Jacob W. Ford ◽  
Tracy E. Strecker ◽  
Ernest Hamel ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Conformationally Restricted ◽  
Structural Analogues ◽  
Synthesis And Biological Evaluation

Cyclic chalcones and structural analogues evaluated as cytotoxic agents.

scholarly journals Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates

2019 ◽  
Vol 31 (10) ◽  
pp. 2389-2393
Author(s):  
Sravanthi Siliveri ◽  
Harinadha Babu Vamaraju ◽  
Shivaraj
Keyword(s):  
Antibacterial Activity ◽  
Double Bond ◽  
Spectral Data ◽  
Biological Evaluation ◽  
Significant Protection ◽  
Edema Formation ◽  
Anti Inflammatory ◽  
Alkoxy Groups ◽  
Oxidative Difunctionalization ◽  
Synthesis And Biological Evaluation

In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with the reagent N-chloro succinimide by the addition of both chlorine and alkoxy groups crosswise the chromene double bond. The addition of base results in the construction of dihydrofuran derivatives by ring contraction. The structures of newly synthesized compounds were characterized on the basis of physical and spectral data. Synthesized compounds were evaluated for antibacterial and anti-inflammatory activities. All the compounds exhibited significant antibacterial activity against all the four strains of bacteria and their MICs ranged between 1.56 and 12.55 μg/mL. In anti-inflammatory screening, among all the tested compounds, compounds 7, 8, 9, 11, 12, 13, 14, 16, 17 and 18 exhibited significant protection against the edema formation at a concentration of 100 mg/kg.

Proline–Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues

2003 ◽  
Vol 11 (8) ◽  
pp. 1677-1683 ◽  
Author(s):  
Mario Paglialunga Paradisi ◽  
Adriano Mollica ◽  
Ivana Cacciatore ◽  
Antonio Di Stefano ◽  
Francesco Pinnen ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Biological Evaluation of Conformationally Restricted Rivastigmine Analogues

2004 ◽  
Vol 47 (24) ◽  
pp. 5945-5952 ◽  
Author(s):  
Maria Laura Bolognesi ◽  
Manuela Bartolini ◽  
Andrea Cavalli ◽  
Vincenza Andrisano ◽  
Michela Rosini ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides

2015 ◽  
Vol 13 (35) ◽  
pp. 9300-9313 ◽  
Author(s):  
Hubert Hřebabecký ◽  
Eliška Procházková ◽  
Michal Šála ◽  
Pavla Plačková ◽  
Eva Tloušťová ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

We prepared a novel series of conformationally restricted bicyclonucleosides and nucleotides.

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation

2011 ◽  
Vol 21 (2) ◽  
pp. 764-768 ◽  
Author(s):  
Ornella Mesenzani ◽  
Alberto Massarotti ◽  
Mariateresa Giustiniano ◽  
Tracey Pirali ◽  
Valentina Bevilacqua ◽  
...  
Keyword(s):  
Double Bond ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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