pH and reduction dual-responsive nanogel cross-linked by quaternization reaction for enhanced cellular internalization and intracellular drug delivery

2013 ◽  
Vol 4 (4) ◽  
pp. 1199-1207 ◽  
Author(s):  
Mingqiang Li ◽  
Zhaohui Tang ◽  
Hai Sun ◽  
Jianxun Ding ◽  
Wantong Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cellular Internalization ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

scholarly journals Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 604 ◽  
Author(s):  
Young Choi ◽  
Eun-sook Choi ◽  
Kwan Mun ◽  
Se Lee ◽  
Sung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Therapeutic Effects ◽  
Cancer Therapies ◽  
Drug Delivery Vehicles ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Efficient Delivery ◽  
Poly Ethylene ◽  
Oxidation Of Methionine

Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies.

pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 63070-63078 ◽  
Author(s):  
Shuangjiang Yu ◽  
Chaoliang He ◽  
Qiang Lv ◽  
Hai Sun ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Reducing Agent ◽  
Acidic Environment ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
System P

pH- and reduction-responsive disulfide-crosslinked polyurethane micelles (CL-PUMs) were developed. The CL-PUMs remained stable in normal PBS while selectively swelled or decomposed in response to weakly acidic environment or reducing agent.

Acid/light dual-responsive biodegradable polymeric nanocarriers for efficient intracellular drug delivery

2018 ◽  
Vol 76 (4) ◽  
pp. 1775-1792 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Xiang Cao ◽  
Tian Liang ◽  
Zhiwei Tong
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanocarriers ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery

Soft Matter ◽  
2013 ◽  
Vol 9 (9) ◽  
pp. 2637 ◽  
Author(s):  
Shuangjiang Yu ◽  
Chaoliang He ◽  
Jianxun Ding ◽  
Yilong Cheng ◽  
Wantong Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Triblock Copolymers ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

scholarly journals Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

2017 ◽  
Vol 5 (48) ◽  
pp. 9497-9501 ◽  
Author(s):  
Mingyang Hei ◽  
Jun Wang ◽  
Kelly Wang ◽  
Weiping Zhu ◽  
Peter X. Ma
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Disulfide Bonds ◽  
Mesoporous Silica Nanoparticles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Upper Critical Solution Temperature

A novel, dual responsive and intracellular delivery system was developed by grafting UCST-type polymers onto the surface of mesoporous silica nanoparticles through disulfide bonds.

Dual responsive supramolecular nanogels for intracellular drug delivery

2014 ◽  
Vol 50 (29) ◽  
pp. 3789 ◽  
Author(s):  
Xiaofei Chen ◽  
Li Chen ◽  
Xuemei Yao ◽  
Zhe Zhang ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

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