Single chain polymeric nanoparticles as compartmentalised sensors for metal ions

2012 ◽  
Vol 3 (11) ◽  
pp. 3166 ◽  
Author(s):  
Martijn A. J. Gillissen ◽  
Ilja K. Voets ◽  
E. W. Meijer ◽  
Anja. R. A. Palmans
Keyword(s):  
Metal Ions ◽  
Polymeric Nanoparticles ◽  
Single Chain

scholarly journals Preparation of metallosupramolecular single-chain polymeric nanoparticles and their characterization by Taylor dispersion

2020 ◽  
Vol 11 (2) ◽  
pp. 586-592 ◽  
Author(s):  
Laura N. Neumann ◽  
Dominic A. Urban ◽  
Philipp Lemal ◽  
Sushila Ramani ◽  
Alke Petri-Fink ◽  
...  
Keyword(s):  
Complex Formation ◽  
Metal Ions ◽  
Polymeric Nanoparticles ◽  
Taylor Dispersion ◽  
Dispersion Analysis ◽  
Single Chain ◽  
Ligand Complex ◽  
Dispersed Particles ◽  
Metal Ligand

Polymers with pendant ligands furnish single-chain polymeric nanoparticles upon intramolecular metal–ligand complex formation with different metal-ions and Taylor dispersion analysis is employed to reliably characterize the dispersed particles.

Synthesis of ligand-carrying polymeric nanoparticles for use in extraction and recovery of metal ions

2017 ◽  
Vol 533 ◽  
pp. 179-186 ◽  
Author(s):  
Yong Zen Tan ◽  
Dalin Wu ◽  
Hui Ting Lee ◽  
Hou Wang ◽  
Andrei Honciuc ◽  
...  
Keyword(s):  
Metal Ions ◽  
Polymeric Nanoparticles

BINDING OF HEPARIN TO H-KININOGEN

1987 ◽  
Author(s):  
I Björk ◽  
S T Olson ◽  
J D Shore
Keyword(s):  
Metal Ions ◽  
Light Chain ◽  
Order Rate Constant ◽  
Heparin Therapy ◽  
Heparin Binding ◽  
Divalent Metal Ions ◽  
Contact Activation ◽  
Single Chain ◽  
Uncatalyzed Reaction ◽  
Chain Form

The binding of heparin to kininogen was analyzed by competition of kininogen with anti thrombin for high-affinity heparin. Residual heparin binding to anti thrombin was quantified by the accelerating effect on the anti thrombin-thrombin reaction. The rate of the latter reaction was monitored by displacement of the fluorescent probe, p-aminobenzamidine, from the enzyme. A linear dependence of the observed pseudo-first-order rate constant (kobs) for the heparin-accelerated anti thrombin-thrombin reaction on heparin concentration was achieved by use of catalytic amounts (≤30 nM) of heparin, a 20-fold ratio of anti thrombin to thrombin and thrombin concentrations (0.25 μM) much below the apparent of heparin for thrombin at the high (1 mM) p-aminobenzamidine concentration used. The two-chain form of H-kininogen minimally affected the heparin-accelerated rate of the anti-thrombin-thrombin reaction at pH 7.4 in the absence of metal ions. However, at saturating concentrations of Zn2+ (10 μM), kobs was reduced to 50% at ˜15 nM kininogen and to that of the uncatalyzed reaction at ≥˜0.25 μM. Conversely, at saturating kininogen, a 50% decrease of kobs was observed at ˜0.6 μM Zn2+, i.e. in the plasma concentration range. Other metal ions were effective in the order: Zn2+˜Ni2+>Cu2+>Co2+˜Cd2+. Single-chain H-kininogen and H-kininogen light chain reduced the heparin enhancement in the presence of Zn2+ to the same extent as the two-chain form, whereas L-kininogen had no effect. In the absence of metal ions, the binding of heparin to two-chain H-kini-nogen increased with decreasing pH below 7.4 in a manner consistent with involvement of protonated histidine residues. Thus, heparin presumably binds to the histidine-rich region of the light chain portion of H-kininogen. The elution of two-chain H-kininogen from immobilized dextran sulfate at pH 7.4 was shifted to higher salt concentrations in the presence of 10 μM Zn2+, indicating that metal ions may also enhance H-kininogen binding to surfaces relevant to contact activation reactions. The sensitivity of H-kininogen-surface interactions to divalent metal ions and pH suggest regulation of the interactions by these factors. Like histidine-rich glycoprotein, H-kininogen may also compete with anti thrombin for heparin during heparin therapy.

scholarly journals Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?

2016 ◽  
Vol 7 (3) ◽  
pp. 2011-2015 ◽  
Author(s):  
Patrick J. M. Stals ◽  
Chi-Yuan Cheng ◽  
Lotte van Beek ◽  
Annelies C. Wauters ◽  
Anja R. A. Palmans ◽  
...  
Keyword(s):  
Surface Water ◽  
Functional Groups ◽  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Single Chain ◽  
Catalytic Function ◽  
Radical Polymerisation

A library of water-soluble dynamic single-chain polymeric nanoparticles (SCPN) was prepared using a controlled radical polymerisation technique followed by the introduction of functional groups, including probes at targeted positions.

Depolymerizable, adaptive supramolecular polymer nanoparticles and networks

2014 ◽  
Vol 5 (12) ◽  
pp. 3788-3794 ◽  
Author(s):  
Joshua A. Kaitz ◽  
Catherine M. Possanza ◽  
Yang Song ◽  
Charles E. Diesendruck ◽  
A. Jolanda H. Spiering ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Polymer Networks ◽  
Polymer Nanoparticles ◽  
Cross Linking ◽  
Supramolecular Polymer ◽  
Single Chain ◽  
Degradable Polymer

Depolymerizable polymers are appended with supramolecular cross-linking motifs to enable preparation of tunable single-chain polymeric nanoparticles and degradable polymer networks.

Probing Single-Chain Magnets in a Family of Linear Chain Compounds Constructed by Magnetically Anisotropic Metal-Ions and Cyclohexane-1,2-Dicarboxylate Analogues

2008 ◽  
Vol 47 (23) ◽  
pp. 11202-11211 ◽  
Author(s):  
Yan-Zhen Zheng ◽  
Wei Xue ◽  
Ming-Liang Tong ◽  
Xiao-Ming Chen ◽  
Shao-Liang Zheng
Keyword(s):  
Metal Ions ◽  
Linear Chain ◽  
Single Chain ◽  
Chain Compounds ◽  
Anisotropic Metal ◽  
Single Chain Magnets

Water-Soluble Single-Chain Polymeric Nanoparticles for Highly Selective Cancer Chemotherapy

2020 ◽  
Author(s):  
Chih-Chia Cheng ◽  
Shan-You Huang ◽  
Wen-Lu Fan ◽  
Ai-Wei Lee ◽  
Chih-Wei Chiu ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Single Chain
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