Water-Soluble Single-Chain Polymeric Nanoparticles for Highly Selective Cancer Chemotherapy

2020 ◽  
Author(s):  
Chih-Chia Cheng ◽  
Shan-You Huang ◽  
Wen-Lu Fan ◽  
Ai-Wei Lee ◽  
Chih-Wei Chiu ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Single Chain

scholarly journals Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?

2016 ◽  
Vol 7 (3) ◽  
pp. 2011-2015 ◽  
Author(s):  
Patrick J. M. Stals ◽  
Chi-Yuan Cheng ◽  
Lotte van Beek ◽  
Annelies C. Wauters ◽  
Anja R. A. Palmans ◽  
...  
Keyword(s):  
Surface Water ◽  
Functional Groups ◽  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Single Chain ◽  
Catalytic Function ◽  
Radical Polymerisation

A library of water-soluble dynamic single-chain polymeric nanoparticles (SCPN) was prepared using a controlled radical polymerisation technique followed by the introduction of functional groups, including probes at targeted positions.

Solubilization of Itraconazole by Surfactants and Phospholipid-Surfactant Mixtures: Interplay of Amphiphile Structure, pH and Electrostatic Interactions

2020 ◽  
Author(s):  
Zahari Vinarov ◽  
Gabriela Gancheva ◽  
Nikola Burdzhiev ◽  
Slavka S. Tcholakova
Keyword(s):  
Nmr Spectroscopy ◽  
Electrostatic Interactions ◽  
Triazole Ring ◽  
Water Soluble ◽  
Single Chain ◽  
Surfactant Mixtures ◽  
Solubilization Capacity ◽  
Water Soluble Drugs ◽  
Hydrophobic Chain ◽  
Brick Dust

Although surfactants are frequently used in enabling formulations of poorly water-soluble drugs, the link between their structure and drug solubilization capacity is still unclear. We studied the solubilization of the “brick-dust” molecule itraconazole by 16 surfactants and 3 phospholipid:surfactant mixtures. NMR spectroscopy was used to study in more details the drug-surfactant interactions. Very high solubility of itraconazole (up to 3.6 g/L) was measured in anionic surfactant micelles at pH = 3, due to electrostatic attraction between the oppositely charged (at this pH) drug and surfactant molecules. <sup>1</sup>H NMR spectroscopy showed that itraconazole is ionized at two sites (2+ charge) at these conditions: in the phenoxy-linked piperazine nitrogen and in the dioxolane-linked triazole ring. The increase of amphiphile hydrophobic chain length had a markedly different effect, depending on the amphiphile type: the solubilization capacity of single-chain surfactants increased, whereas a decrease was observed for double-chained surfactants (phosphatidylglycerols). The excellent correlation between the chain melting temperatures of phosphatidylglycerols and itraconazole solubilization illustrated the importance of hydrophobic chain mobility. This study provides rules for selection of itraconazole solubilizers among classical single-chain surfactants and phospholipids. The basic physics underpinning the described effects suggests that these rules should be transferrable to other “brick-dust” molecules.

scholarly journals Novel water-soluble polyurethane nanomicelles for cancer chemotherapy: physicochemical characterization and cellular activities

2012 ◽  
Vol 10 (1) ◽  
pp. 2 ◽  
Author(s):  
Ahmad Khosroushahi ◽  
Hossein Naderi-Manesh ◽  
Hamid Yeganeh ◽  
Jaleh Barar ◽  
Yadollah Omidi
Keyword(s):  
Cancer Chemotherapy ◽  
Physicochemical Characterization ◽  
Water Soluble

Staphylococcus aureus: Production of Extracellular Compounds and Behavior in Foods - A Review

1989 ◽  
Vol 52 (4) ◽  
pp. 267-282 ◽  
Author(s):  
MARGARET I. HALPIN-DOHNALEK ◽  
ELMER H. MARTH
Keyword(s):  
Staphylococcus Aureus ◽  
Dairy Products ◽  
Food Poisoning ◽  
Water Soluble ◽  
Bakery Products ◽  
Single Chain ◽  
Poultry Products ◽  
Heat Stable ◽  
And Behavior ◽  
Red Meats

Growth of Staphylococcus aureus is accompanied by production of such extracellular compounds as hemolysins, nuclease, coagulase, lipase, and enterotoxins. Enterotoxins that can cause food poisoning are produced by about one-third of the coagulase-positive strains of S. aureus. The enterotoxins are a heterogeneous group of heat-stable, water-soluble, single-chain globular proteins having a molecular weight between 28,000 and 35,000 daltons. Production of enterotoxin by appropriate strains of S. aureus is affected by the nutritional quality and pH of the substrate, temperature, atmosphere, sodium chloride (and hence water activity), other chemicals, and competing microorganisms. Outbreaks of staphylococcal food poisoning most often are associated with processed red meats, poultry products (especially chicken salad), sauces, dairy products (especially cheeses), and custard- or cream-filled bakery products. Ham and associated products often are involved in as many as 30% of outbreaks of staphylococcal food poisoning. Most outbreaks result from the combined effects of contamination of the food, often through unsanitary handling, with S. aureus and holding the food at the wrong temperature thus allowing growth and synthesis of enterotoxin by the pathogen.

Water-Soluble, pH Responsive Polymeric Nanoparticles: A Modular Approach

2020 ◽  
Vol 2 (7) ◽  
pp. 2499-2503
Author(s):  
Marcel Klein-Hitpaß ◽  
Jan-Erik Ostwaldt ◽  
Carsten Schmuck ◽  
Michael Giese
Keyword(s):  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Modular Approach ◽  
Ph Responsive

Depolymerizable, adaptive supramolecular polymer nanoparticles and networks

2014 ◽  
Vol 5 (12) ◽  
pp. 3788-3794 ◽  
Author(s):  
Joshua A. Kaitz ◽  
Catherine M. Possanza ◽  
Yang Song ◽  
Charles E. Diesendruck ◽  
A. Jolanda H. Spiering ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Polymer Networks ◽  
Polymer Nanoparticles ◽  
Cross Linking ◽  
Supramolecular Polymer ◽  
Single Chain ◽  
Degradable Polymer

Depolymerizable polymers are appended with supramolecular cross-linking motifs to enable preparation of tunable single-chain polymeric nanoparticles and degradable polymer networks.

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for intratumoral administration with improved therapeutic efficacy in tumor-bearing mice

2015 ◽  
Vol 3 (39) ◽  
pp. 7707-7717 ◽  
Author(s):  
Jinyan Lin ◽  
Yanxiu Li ◽  
Yang Li ◽  
Fei Cui ◽  
Fei Yu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Polymeric Nanoparticles ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Highly Efficient

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for highly efficient cancer chemotherapy: more elongated is better.

Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan

Biomaterials ◽  
2009 ◽  
Vol 30 (12) ◽  
pp. 2340-2348 ◽  
Author(s):  
Yan Sheng ◽  
Changsheng Liu ◽  
Yuan Yuan ◽  
Xinyi Tao ◽  
Fan Yang ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Water Soluble
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