Fluorescent nanoparticles from self-assembly of β-cyclodextrin-functionalized fluorene copolymers for organic molecule sensing and cell labeling

2012 ◽  
Vol 3 (9) ◽  
pp. 2444 ◽  
Author(s):  
Li Qun Xu ◽  
Bin Zhang ◽  
Rong Wang ◽  
Yu Chen ◽  
Koon-Gee Neoh ◽  
...  
Keyword(s):  
Self Assembly ◽  
Organic Molecule ◽  
Cell Labeling ◽  
Fluorescent Nanoparticles

scholarly journals Organic Nanoparticles Based on D-A-D Small Molecule: Self-Assembly, Photophysical Properties, and Synergistic Photodynamic/Photothermal Effects

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 502
Author(s):  
Liangliang Yue ◽  
Haolan Li ◽  
Qi Sun ◽  
Xiaogang Luo ◽  
Fengshou Wu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Organic Molecule ◽  
High Efficiency ◽  
Photophysical Properties ◽  
Coupling Reaction ◽  
Ros Generation ◽  
Dead Cell ◽  
Minimal Invasiveness ◽  
Sonogashira Coupling Reaction ◽  
Potential Strategy

Cancer is one of the major diseases threatening human health. Traditional cancer treatments have notable side-effects as they can damage the immune system. Recently, phototherapy, as a potential strategy for clinical cancer therapy, has received wide attention due to its minimal invasiveness and high efficiency. Herein, a small organic molecule (PTA) with a D-A-D structure was prepared via a Sonogashira coupling reaction between the electron-withdrawing dibromo-perylenediimide and electron-donating 4-ethynyl-N,N-diphenylaniline. The amphiphilic organic molecule was then transformed into nanoparticles (PTA-NPs) through the self-assembling method. Upon laser irradiation at 635 nm, PTA-NPs displayed a high photothermal conversion efficiency (PCE = 43%) together with efficient reactive oxygen species (ROS) generation. The fluorescence images also indicated the production of ROS in cancer cells with PTA-NPs. In addition, the biocompatibility and photocytotoxicity of PTA-NPs were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead cell co-staining test. Therefore, the as-prepared organic nanomaterials were demonstrated as promising nanomaterials for cancer phototherapy in the clinic.

Directed self-assembly of peptide–diketopyrrolopyrrole conjugates – a platform for bio-organic thin film preparation

Soft Matter ◽  
2020 ◽  
Vol 16 (28) ◽  
pp. 6563-6571
Author(s):  
Aakanksha Rani ◽  
Iman Kavianinia ◽  
Paul Hume ◽  
Luis M. De Leon-Rodriguez ◽  
Shinji Kihara ◽  
...  
Keyword(s):  
Thin Film ◽  
Long Range ◽  
Self Assembly ◽  
Organic Molecule ◽  
Water Solubility ◽  
Organic Thin Film ◽  
Thin Film Preparation ◽  
Film Preparation

Increased water solubility and long-range intermolecular ordering have been introduced into the fluorescent organic molecule thiophene-diketopyrrolopyrrole via its conjugation to the octapeptide HEFISTAH, derived from a protein–protein β-interface.

Guided Self-Assembly of Metal Atoms on Silicon Using Organic-Molecule Templating

2012 ◽  
Vol 134 (37) ◽  
pp. 15312-15317 ◽  
Author(s):  
Daniel R. Belcher ◽  
Marian W. Radny ◽  
Steven R. Schofield ◽  
Phillip V. Smith ◽  
Oliver Warschkow
Keyword(s):  
Self Assembly ◽  
Organic Molecule ◽  
Metal Atoms

scholarly journals Self-assembly of chiral fluorescent nanoparticles based on water-soluble L-tryptophan derivatives of p-tert-butylthiacalix[4]arene

2017 ◽  
Vol 8 ◽  
pp. 1825-1835 ◽  
Author(s):  
Pavel L Padnya ◽  
Irina A Khripunova ◽  
Olga A Mostovaya ◽  
Timur A Mukhametzyanov ◽  
Vladimir G Evtugyn ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Self Assembly ◽  
Water Soluble ◽  
Fluorescent Nanoparticles ◽  
Spectral Emission ◽  
Chiroptical Properties ◽  
Transmission Electron ◽  
Derivatives Of ◽  
Tryptophan Derivatives ◽  
Positively Charged

New water-soluble tetra-substituted derivatives of p-tert-butylthiacalix[4]arene containing fragments of L-tryptophan in cone and 1,3-alternate conformations were obtained. It was shown that the resulting compounds form stable, positively charged aggregates of 86–134 nm in diameter in water at a concentration of 1 × 10−4 M as confirmed by dynamic light scattering, scanning electron microscopy and transmission electron microscopy. It was established that these aggregates are fluorescently active and chiral. A distinctive feature of the compounds is the pronounced dependence of their spectral (emission and chiroptical) properties on the polarity of the solvent and the length of the linker between the macrocyclic and fluorophore parts of the molecule.

Fabrication of amphiphilic fluorescent nanoparticles with an AIE feature via a one-pot clickable mercaptoacetic acid locking imine reaction: synthesis, self-assembly and bioimaging

2016 ◽  
Vol 7 (27) ◽  
pp. 4559-4566 ◽  
Author(s):  
Qing Wan ◽  
Meiying Liu ◽  
Dazhuang Xu ◽  
Liucheng Mao ◽  
Hongye Huang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Mercaptoacetic Acid ◽  
Fluorescent Nanoparticles ◽  
Reaction Synthesis ◽  
One Pot ◽  
Organic Nanoparticles ◽  
Water Dispersible ◽  
Fluorescent Organic Nanoparticles

Water dispersible and non-toxic AIE active fluorescent organic nanoparticles were fabricatedviaa one-pot clickable mercaptoacetic acid locking imine reaction.

An unsymmetrical non-fullerene acceptor: synthesis via direct heteroarylation, self-assembly, and utility as a low energy absorber in organic photovoltaic cells

2017 ◽  
Vol 53 (73) ◽  
pp. 10168-10171 ◽  
Author(s):  
Abby-Jo Payne ◽  
Shi Li ◽  
Sergey V. Dayneko ◽  
Chad Risko ◽  
Gregory C. Welch
Keyword(s):  
Self Assembly ◽  
Organic Molecule ◽  
Photovoltaic Cells ◽  
Low Energy ◽  
Perylene Diimide ◽  
Organic Photovoltaic ◽  
Organic Photovoltaic Cells ◽  
Energy Absorber ◽  
Design And Synthesis

This study reports on the design and synthesis of an unsymmetrical π-conjugated organic molecule composed of perylene diimide, thienyl diketopyrrolopyrrole, and indoloquinoxaline pieced together using direct heteroarylation.

PHOTOSWITCHABLE NANOFLUOROPHORES FOR INNOVATIVE BIOIMAGING

2011 ◽  
Vol 04 (04) ◽  
pp. 395-408 ◽  
Author(s):  
MING-QIANG ZHU ◽  
GUO-FENG ZHANG ◽  
CHONG LI ◽  
YA-JING LI ◽  
MATTHEW P. ALDRED ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Self Assembly ◽  
Fluorescent Proteins ◽  
Super Resolution ◽  
Future Research ◽  
Fluorescent Nanoparticles ◽  
Biological Targets ◽  
Cellular Processes ◽  
Cellular Events ◽  
Fluorescence Photoswitching

Photosensitive fluorescent probes have become powerful tools in chemical biology and molecular biophysics, which are used to investigate cellular processes with high temporal and spatial resolution. Accordingly, photosensitive fluorescent probes, including photoactivatable, photoconvertible, and photoswitchable fluorophores, have been extensively developed during the past decade. The photoswitchable fluorophores have received much attention because they highlight cellular events clearly. This minireview summarizes recent advances of using reversibly photoswitchable fluorophores and their applications in innovative bioimaging. Photoswitchable fluorophores include photoswitchable fluorescent proteins, photoswitchable fluorescent organic molecules (dyes), and photoswitchable fluorescent nanoparticles. Several strategies have been developed to synthesize photoswitchable fluorophores, including engineering combination proteins, chemical synthesis, polymerization, and self-assembly. Here we concentrate on polymer nanoparticles with optically switchable emission properties: either fluorescence on/off or dual-alternating-color fluorescence photoswitching. The essential mechanisms of fluorescence photoswitching enable different types of photoswitchable fluorophores to change emission intensity or wavelength (color) and thus validating the basis of the fluorescence on/off or dual-color photoswitching design. Generally the possible applications of any fluorophores are to label biological targets, followed by specific imaging. The newly developed photoswitchable fluorophores enable super-resolution fluorescence imaging because of their photosensitive emission. Finally, we summarize the important area regarding future research and development on photoswitchable fluorescent nanoparticles.

Cell labeling efficiency of layer-by-layer self-assembly modified silica nanoparticles

2009 ◽  
Vol 24 (4) ◽  
pp. 1317-1321 ◽  
Author(s):  
Gang Liu ◽  
Jing Tian ◽  
Chen Liu ◽  
Hua Ai ◽  
Zhongwei Gu ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Self Assembly ◽  
Laser Scanning ◽  
Control Cell ◽  
Silica Nanoparticle ◽  
Laser Scanning Microscopy ◽  
Cell Labeling ◽  
Cell Uptake ◽  
Confocal Laser ◽  
Layer By Layer

In the present study, we compared cytotoxicity and cell uptake of silica nanoparticles with four different surface coatings generated through layer-by-layer self-assembly. Rabbit mesenchymal stem cells (rMSCs) were labeled with silica nanoparticles of different coatings including poly(ethyleneimine) (PEI), poly(allylamine hydrochloride) (PAH), poly(anetholesulfonic acid, sodium salt) (PAS), and dextran sulfate. The MTT [3-(4, 5-dimethylthiazol-2)-2, 5-diphenyl-2H-tetrazolium bromide] test was performed to quantify the cell biocompatibility. The cellular uptake of those silica nanoparticles was determined by flow cytometry and confocal laser scanning microscopy. The results showed that all examined silica nanoparticles were stable in aqueous phase with high monodispersity. Labeled rMSCs are unaffected in their viability, apoptosis, and differentiation capacities. The silica nanoparticle-coated synthetic polycations such as PEI or PAH have higher cell internalization than negatively charged polyelectrolytes. The ability to control cell uptake of different particles may have applications in cell labeling, cell separation, and other biomedical applications.

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