Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin

2012 ◽  
Vol 3 (8) ◽  
pp. 1958 ◽  
Author(s):  
Liming Zhang ◽  
Zhuoxuan Lu ◽  
Xiaolong Li ◽  
Yan Deng ◽  
Fengqin Zhang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Effective Delivery ◽  
Poly Ethylene

Tryptophan 2,3-dioxygenase-like activity of manganese (III) porphyrin bound to bovine serum albumin modified with poly(ethylene glycol)

1993 ◽  
Vol 81 (2) ◽  
pp. L13-L17 ◽  
Author(s):  
Takashi Sagawa ◽  
Hitoshi Ishida ◽  
Kenji Urabe ◽  
Kohji Yoshinaga ◽  
Katsutoshi Ohkubo
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Complex Formation of Bovine Serum Albumin with a Poly(ethylene glycol) Lipid Conjugate

2007 ◽  
Vol 8 (7) ◽  
pp. 2244-2249 ◽  
Author(s):  
Valeria Castelletto ◽  
Marta Krysmann ◽  
Antonios Kelarakis ◽  
Paula Jauregi
Keyword(s):  
Bovine Serum Albumin ◽  
Complex Formation ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Lipid Conjugate

Biodegradable star-shaped polycyclic ester elastomers: Preparation, degradability, protein release, and biocompatibility in vitro

2016 ◽  
Vol 32 (2) ◽  
pp. 178-195 ◽  
Author(s):  
Fangyuan Guo ◽  
Wei Zhang ◽  
Xiaohong Pei ◽  
Xia Shen ◽  
Qinying Yan ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Interleukin 2 ◽  
Protein Drugs ◽  
Poly Ethylene Glycol ◽  
Degree Of Swelling ◽  
Poly Ethylene

Effective local delivery methods for sustained and stable release of protein drugs are urgently needed. Biodegradable elastomers based on star-shaped polycyclic esters have received attention for their drug-loading and drug-release kinetics. However, the long degradation periods resulting from their strong lipophilicity greatly hinder their application. In this study, we synthesized new cross-linked elastomers based on methyl-acrylic-star-poly(ϵ-caprolactone- co-d,l-lactide) cyclic ester and methyl-bi-acrylic-poly(ϵ-caprolactone-b-poly(ethylene glycol)-b-ϵ-caprolactone) with different molecular weights; determined their physical, thermal, and morphological characteristics; and studied their in vitro degradation and release of bovine serum albumin and recombinant human interleukin 2. Elastomer hydrophilicity improved with the introduction of methyl-bi-acrylic-poly(ϵ-caprolactone-b-poly(ethylene glycol)-b-ϵ-caprolactone), and a shorter degradation period (~25 weeks) was achieved. Additionally, the degradation rate could be adjusted by varying the composition of methyl-bi-acrylic-poly(ϵ-caprolactone-b-poly(ethylene glycol)-b-ϵ-caprolactone) to directly influence the degree of swelling, cross-linking density, and sol content of the elastomer. The controlled rate of bovine serum albumin and recombinant human interleukin 2 release increased with a larger degree of swelling, higher sol content, and lower cross-link density of the elastomers. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide analysis showed good biocompatibility. These results suggest that these new elastomers are potential candidates for carrier materials in controlled, implantable delivery systems for protein drugs and other biomedical applications.

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