Halogenated silicon(iv) phthalocyanines with axial poly(ethylene glycol) chains. Synthesis, spectroscopic properties, complexation with bovine serum albumin and in vitro photodynamic activitiesDedicated to Prof. Malcolm L. H. Green on the occasion of his retirement, with our warmest congratulations.

2004 ◽  
Vol 28 (3) ◽  
pp. 348 ◽  
Author(s):  
Jian-Dong Huang ◽  
Shuangqing Wang ◽  
Pui-Chi Lo ◽  
Wing-Ping Fong ◽  
Wing-Hung Ko ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Spectroscopic Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Biodegradable star-shaped polycyclic ester elastomers: Preparation, degradability, protein release, and biocompatibility in vitro

2016 ◽  
Vol 32 (2) ◽  
pp. 178-195 ◽  
Author(s):  
Fangyuan Guo ◽  
Wei Zhang ◽  
Xiaohong Pei ◽  
Xia Shen ◽  
Qinying Yan ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Interleukin 2 ◽  
Protein Drugs ◽  
Poly Ethylene Glycol ◽  
Degree Of Swelling ◽  
Poly Ethylene

Effective local delivery methods for sustained and stable release of protein drugs are urgently needed. Biodegradable elastomers based on star-shaped polycyclic esters have received attention for their drug-loading and drug-release kinetics. However, the long degradation periods resulting from their strong lipophilicity greatly hinder their application. In this study, we synthesized new cross-linked elastomers based on methyl-acrylic-star-poly(ϵ-caprolactone- co-d,l-lactide) cyclic ester and methyl-bi-acrylic-poly(ϵ-caprolactone-b-poly(ethylene glycol)-b-ϵ-caprolactone) with different molecular weights; determined their physical, thermal, and morphological characteristics; and studied their in vitro degradation and release of bovine serum albumin and recombinant human interleukin 2. Elastomer hydrophilicity improved with the introduction of methyl-bi-acrylic-poly(ϵ-caprolactone-b-poly(ethylene glycol)-b-ϵ-caprolactone), and a shorter degradation period (~25 weeks) was achieved. Additionally, the degradation rate could be adjusted by varying the composition of methyl-bi-acrylic-poly(ϵ-caprolactone-b-poly(ethylene glycol)-b-ϵ-caprolactone) to directly influence the degree of swelling, cross-linking density, and sol content of the elastomer. The controlled rate of bovine serum albumin and recombinant human interleukin 2 release increased with a larger degree of swelling, higher sol content, and lower cross-link density of the elastomers. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide analysis showed good biocompatibility. These results suggest that these new elastomers are potential candidates for carrier materials in controlled, implantable delivery systems for protein drugs and other biomedical applications.

Tryptophan 2,3-dioxygenase-like activity of manganese (III) porphyrin bound to bovine serum albumin modified with poly(ethylene glycol)

1993 ◽  
Vol 81 (2) ◽  
pp. L13-L17 ◽  
Author(s):  
Takashi Sagawa ◽  
Hitoshi Ishida ◽  
Kenji Urabe ◽  
Kohji Yoshinaga ◽  
Katsutoshi Ohkubo
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Complex Formation of Bovine Serum Albumin with a Poly(ethylene glycol) Lipid Conjugate

2007 ◽  
Vol 8 (7) ◽  
pp. 2244-2249 ◽  
Author(s):  
Valeria Castelletto ◽  
Marta Krysmann ◽  
Antonios Kelarakis ◽  
Paula Jauregi
Keyword(s):  
Bovine Serum Albumin ◽  
Complex Formation ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Lipid Conjugate

scholarly journals Synthesis and Characterization of Polymer-Based Coatings Modified with Bioactive Ceramic and Bovine Serum Albumin

2021 ◽  
Vol 12 (2) ◽  
pp. 21
Author(s):  
Wioletta Florkiewicz ◽  
Dagmara Słota ◽  
Angelika Placek ◽  
Klaudia Pluta ◽  
Bożena Tyliszczak ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Ftir Spectroscopy ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Sem Imaging ◽  
Poly Ethylene

This study involves the synthesis of hydroxyapatite and describes the preparation and characterization of polymer coatings based on poly(ethylene glycol) diacrylate and poly(ethylene glycol) and modified with bovine serum albumin and hydroxyapatite. Hydroxyapatite was obtained by wet chemical synthesis and characterized by X-ray diffraction and FTIR spectroscopy, and its Ca/P molar ratio was determined (1.69 ± 0.08). The ceramic and bovine serum albumin were used in the preparation of composite materials with the polymeric matrix. The chemical composition of coatings was characterized with FTIR spectroscopy, and their morphology was recorded with SEM imaging. Moreover, the measurements of surface roughness parameters and stereometric research were performed. The prepared coatings were subjected to in vitro studies in simulated body fluid and artificial saliva. Changes in chemical composition and morphology after immersion were examined with FTIR spectroscopy and SEM imaging. Based on the conducted research, it can be stated that applied modifiers promote the biomineralization process. The roughness analysis confirmed prepared materials were characterized by the micrometer-scale topography. The materials morphology and roughness, and the morphology of the newly formed apatite deposit, were dependent on the type of the used modifier, and the artificial fluid used in in vitro studies.

Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin

2012 ◽  
Vol 3 (8) ◽  
pp. 1958 ◽  
Author(s):  
Liming Zhang ◽  
Zhuoxuan Lu ◽  
Xiaolong Li ◽  
Yan Deng ◽  
Fengqin Zhang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Ethylene Glycol ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Effective Delivery ◽  
Poly Ethylene
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