scholarly journals Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

2013 ◽  
Vol 11 (6) ◽  
pp. 938-954 ◽  
Author(s):  
Danielle M. Stacy ◽  
Sebastian T. Le Quement ◽  
Casper L. Hansen ◽  
Janie W. Clausen ◽  
Tim Tolker-Nielsen ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biological Evaluation ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of novel N-α-haloacylated homoserine lactones as quorum sensing modulators

2014 ◽  
Vol 10 ◽  
pp. 2539-2549 ◽  
Author(s):  
Michail Syrpas ◽  
Ewout Ruysbergh ◽  
Christian V Stevens ◽  
Norbert De Kimpe ◽  
Sven Mangelinckx
Keyword(s):  
Quorum Sensing ◽  
Acyl Chain ◽  
Biological Evaluation ◽  
Chemical Probes ◽  
Homoserine Lactones ◽  
Structure Activity ◽  
Acylated Homoserine Lactones ◽  
Synthesis And Biological Evaluation ◽  
Reduced Activity ◽  
Carbonyl Function

Novel N-α-haloacylated homoserine lactones, in which a halogen atom was introduced at the α-position of the carbonyl function of the N-acyl chain, have been studied as quorum sensing (QS) modulators and compared with a library of natural N-acylated homoserine lactones (AHLs). The series of novel analogues consists of α-chloro, α-bromo and α-iodo AHL analogues. Furthermore, the biological QS activity of the synthetic AHL analogues compared to the natural AHLs was evaluated. Halogenated analogues demonstrated a reduced activity in the Escherichia coli JB523 bioassay, with the α-iodo lactones being the less active ones and the α-chloro AHLs the most potent QS agonists. Most of the α-haloacylated analogues did not exhibit a significant reduction when tested in the QS inhibition test. Therefore, these novel analogues could be utilized as chemical probes for QS structure–activity studies.

Solid-Phase Synthesis and Biological Evaluation ofN-DipeptidoL-Homoserine Lactones as Quorum Sensing Activators

ChemBioChem ◽  
2014 ◽  
Vol 15 (3) ◽  
pp. 460-465 ◽  
Author(s):  
Mette R. Hansen ◽  
Sebastian T. Le Quement ◽  
Tim H. Jakobsen ◽  
Søren Skovstrup ◽  
Olivier Taboureau ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Evaluation ◽  
Phase Synthesis ◽  
Homoserine Lactones ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa

RSC Advances ◽  
2019 ◽  
Vol 9 (50) ◽  
pp. 29273-29292 ◽  
Author(s):  
Singireddi Srinivasarao ◽  
Adinarayana Nandikolla ◽  
Shashidhar Nizalapur ◽  
Tsz Tin Yu ◽  
Sravani Pulya ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Cell Line ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Hek 293 ◽  
Line P ◽  
Synthesis And Biological Evaluation ◽  
Hek 293 Cell Line

Out of 40 benzimdazoles, 12 exhibited potent QSI activity against P. aeruginosa6p, most active QSI is docked to LasR and is less toxic against HEK 293 cell line.

Influence of the d/l configuration of N-acyl-homoserine lactones (AHLs) and analogues on their Lux-R dependent quorum sensing activity

2018 ◽  
Vol 77 ◽  
pp. 215-222 ◽  
Author(s):  
Si-Zhe Li ◽  
Rui Xu ◽  
Mohammed Ahmar ◽  
Catherine Goux-Henry ◽  
Yves Queneau ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones
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