scholarly journals Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

2012 ◽  
Vol 10 (32) ◽  
pp. 6537 ◽  
Author(s):  
Sebastian Müller ◽  
Deborah A. Sanders ◽  
Marco Di Antonio ◽  
Stephanos Matsis ◽  
Jean-François Riou ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Cancer ◽  
Telomere Dysfunction ◽  
Human Cancer Cells

scholarly journals N-ω-chloroacetyl-l-ornithine, a new competitive inhibitor of ornithine decarboxylase, induces selective growth inhibition and cytotoxicity on human cancer cells versus normal cells

2014 ◽  
Vol 30 (3) ◽  
pp. 345-353 ◽  
Author(s):  
Miriam Marlene Medina-Enríquez ◽  
Verónica Alcántara-Farfán ◽  
Leopoldo Aguilar-Faisal ◽  
José Guadalupe Trujillo-Ferrara ◽  
Lorena Rodríguez-Páez ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Ornithine Decarboxylase ◽  
Human Cancer ◽  
Competitive Inhibitor ◽  
Selective Growth ◽  
Normal Cells ◽  
Human Cancer Cells

Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers

2006 ◽  
Vol 16 (19) ◽  
pp. 5014-5017 ◽  
Author(s):  
Jae Yeol Lee ◽  
Seong Jun Park ◽  
Sung Jun Park ◽  
Min Joo Lee ◽  
Hyewhon Rhim ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Calcium Channel ◽  
Cancer Cells ◽  
Calcium Channel Blockers ◽  
Human Cancer ◽  
Channel Blockers ◽  
Human Cancer Cells

scholarly journals In vitro growth inhibition of human cancer cells by novel honokiol analogs

2012 ◽  
Vol 20 (10) ◽  
pp. 3202-3211 ◽  
Author(s):  
Jyh Ming Lin ◽  
A.S. Prakasha Gowda ◽  
Arun K. Sharma ◽  
Shantu Amin
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Human Cancer Cells

scholarly journals Heat Stress-Induced Multiple Multipolar Divisions of Human Cancer Cells

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 888 ◽  
Author(s):  
Chen ◽  
Liu ◽  
Huang ◽  
Li ◽  
Zhao ◽  
...  
Keyword(s):  
Heat Stress ◽  
Cancer Cells ◽  
Cell Fusion ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Daughter Cells ◽  
Mitotic Slippage ◽  
Polyploid Cells ◽  
Mcf 7

Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7 cells. Our results show that, besides facilitating centrosome aberration, polyploidy induced by heat stress is another mechanism that causes multipolar cell divisions, in which polyploid cancer cells engendered by mitotic slippage, cytokinesis failure, and cell fusion. Furthermore, we also find that the fates of theses polyploid cells depend on their origins, in the sense that the polyploid cells generated by mitotic slippage experience bipolar divisions with a higher rate than multipolar divisions, while those polyploid cells induced by both cytokinesis failure and cell fusion have a higher frequency of multipolar divisions compared with bipolar divisions. This work indicates that heat stress-induced multiple multipolar divisions of cancer cells usually produce aneuploid daughter cells, and might lead to genetically unstable cancer cells and facilitate tumor heterogeneity.

scholarly journals Growth inhibition and apoptosis-inducing effect on human cancer cells by RCE-4, a spirostanol saponin derivative from natural medicines

2012 ◽  
Vol 31 (1) ◽  
pp. 219-224 ◽  
Author(s):  
GUIPING WANG ◽  
WENFENG HUANG ◽  
HAIBO HE ◽  
XUEJIAO FU ◽  
JUNZHI WANG ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Natural Medicines
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