scholarly journals In vitro growth inhibition of human cancer cells by novel honokiol analogs

2012 ◽  
Vol 20 (10) ◽  
pp. 3202-3211 ◽  
Author(s):  
Jyh Ming Lin ◽  
A.S. Prakasha Gowda ◽  
Arun K. Sharma ◽  
Shantu Amin
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Human Cancer Cells

Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers

2006 ◽  
Vol 16 (19) ◽  
pp. 5014-5017 ◽  
Author(s):  
Jae Yeol Lee ◽  
Seong Jun Park ◽  
Sung Jun Park ◽  
Min Joo Lee ◽  
Hyewhon Rhim ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Calcium Channel ◽  
Cancer Cells ◽  
Calcium Channel Blockers ◽  
Human Cancer ◽  
Channel Blockers ◽  
Human Cancer Cells

scholarly journals Occurrence of a Taurine Derivative in an Antarctic Glass Sponge

2014 ◽  
Vol 9 (4) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Marianna Carbone ◽  
Laura Núñez-Pons ◽  
M. Letizia Ciavatta ◽  
Francesco Castelluccio ◽  
Conxita Avila ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cancer Cells ◽  
Natural Product ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Butanol Extract ◽  
Human Cancer Cells ◽  
Hexactinellid Sponge ◽  
Growth Inhibitory

The n-butanol extract of an Antarctic hexactinellid sponge, Anoxycalyx (Scolymastra) joubini, was found to contain a taurine-conjugated anthranilic acid, never reported so far either as a natural product or by synthesis. The compound was inactive against human cancer cells in an in vitro growth inhibitory test, and also showed no antibacterial activity.

Structure–Activity Relationship Analysis of Bufadienolide-Induced in Vitro Growth Inhibitory Effects on Mouse and Human Cancer Cells

2013 ◽  
Vol 76 (6) ◽  
pp. 1078-1084 ◽  
Author(s):  
Laetitia Moreno Y. Banuls ◽  
Ernst Urban ◽  
Michel Gelbcke ◽  
François Dufrasne ◽  
Brigitte Kopp ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Activity Relationship ◽  
In Vitro Growth ◽  
Inhibitory Effects ◽  
Human Cancer Cells ◽  
Relationship Analysis ◽  
Structure Activity ◽  
Growth Inhibitory

Glanduliferins A and B, two new glucosylated steroids from Impatiens glandulifera, with in vitro growth inhibitory activity in human cancer cells

Fitoterapia ◽  
2016 ◽  
Vol 109 ◽  
pp. 138-145 ◽  
Author(s):  
Alessio Cimmino ◽  
Véronique Mathieu ◽  
Marco Evidente ◽  
Marlène Ferderin ◽  
Laetitia Moreno Y Banuls ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
In Vitro Growth ◽  
Impatiens Glandulifera ◽  
Human Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

A new method for the three-dimensional in vitro growth of human cancer cells

1983 ◽  
Vol 147 (2) ◽  
pp. 454-460 ◽  
Author(s):  
H KUPCHIK ◽  
R LANGER ◽  
C HABERERN ◽  
S ELDERINY ◽  
M OBRIEN
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Three Dimensional ◽  
New Method ◽  
In Vitro Growth ◽  
Human Cancer Cells

scholarly journals A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

2021 ◽  
Vol 22 (16) ◽  
pp. 8372
Author(s):  
Ana María Zárate ◽  
Christian Espinosa-Bustos ◽  
Simón Guerrero ◽  
Angélica Fierro ◽  
Felipe Oyarzún-Ampuero ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Antitumour Activity ◽  
Anticancer Compounds ◽  
Human Cancer Cells ◽  
Cycle Arrest ◽  
Apoptosis Inducer ◽  
Purine Ring

The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists having the versatile purine ring as a scaffold were designed, synthesised, and biologically tested to provide an insight to their mechanism of action. Compound 4s was the most active and the best inhibitor of cell growth and selectively cytotoxic to cancer cells. 4s induced cell cycle arrest, apoptosis, a reduction in colony formation and downregulation of PTCH and GLI1 expression. BODIPY-cyclopamine displacement assays confirmed 4s is a SMO antagonist. In vivo, 4s strongly inhibited tumour relapse and metastasis of melanoma cells in mice. In vitro, 4s was more efficient than vismodegib to induce apoptosis in human cancer cells and that might be attributed to its dual ability to function as a SMO antagonist and apoptosis inducer.

Rhodium(i) N-heterocyclic carbene complexes: synthesis and cytotoxic properties

2021 ◽  
Vol 45 (11) ◽  
pp. 5176-5183
Author(s):  
Ichraf Slimani ◽  
Serap Şahin-Bölükbaşı ◽  
Mustafa Ulu ◽  
Enes Evren ◽  
Nevin Gürbüz ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mtt Assay ◽  
Incubation Time ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Carbene Complexes ◽  
Human Cancer Cells ◽  
Benzimidazolium Salts ◽  
Ht 29

A series of benzimidazolium salts and their [RhCl(NHC)(COD)] complexes were synthesized. All compounds were screened for in vitro cytotoxic activities against a panel of human cancer cells (HT-29 colon, Ishikawa endometrial, U-87 glioblastoma) using the MTT assay for 48 h incubation time.

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