Design, synthesis and binding studies of a novel quadruple ADDA hydrogen-bond array

2012 ◽  
Vol 10 (25) ◽  
pp. 4899 ◽  
Author(s):  
Maria L. Pellizzaro ◽  
Simon A. Barrett ◽  
Julie Fisher ◽  
Andrew J. Wilson
Keyword(s):  
Hydrogen Bond ◽  
Binding Studies ◽  
Design Synthesis

Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors

2010 ◽  
Vol 16 (30) ◽  
pp. 9123-9131 ◽  
Author(s):  
Xiaoming He ◽  
Fernando Herranz ◽  
Eddie Chung-Chin Cheng ◽  
Ramon Vilar ◽  
Vivian Wing-Wah Yam
Keyword(s):  
Anion Binding ◽  
Binding Studies ◽  
Design Synthesis ◽  
Thiolate Complexes

Design, Synthesis, and Binding Studies of New Potent Ligands of Cannabinoid Receptors

2005 ◽  
Vol 48 (23) ◽  
pp. 7343-7350 ◽  
Author(s):  
Antonella Brizzi ◽  
Vittorio Brizzi ◽  
Maria Grazia Cascio ◽  
Tiziana Bisogno ◽  
Rossella Sirianni ◽  
...  
Keyword(s):  
Cannabinoid Receptors ◽  
Binding Studies ◽  
Design Synthesis

scholarly journals Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides

2010 ◽  
Vol 6 ◽  
Author(s):  
Ana Maria Castilla ◽  
M Morgan Conn ◽  
Pablo Ballester
Keyword(s):  
Hydrogen Bonding ◽  
Peptide Ligands ◽  
Binding Studies ◽  
Design Synthesis ◽  
Macrocyclic Receptors ◽  
H Nmr ◽  
Hydrogen Bonding Pattern ◽  
Conformational Equilibria ◽  
Β Sheets ◽  
Β Sheet

We present here the design, synthesis, and analysis of a series of receptors for peptide ligands inspired by the hydrogen-bonding pattern of protein β-sheets. The receptors themselves can be regarded as strands 1 and 3 of a three-stranded β-sheet, with cross-linking between the chains through the 4-position of adjacent phenylalanine residues. We also report on the conformational equilibria of these receptors in solution as well as on their tendency to dimerize. 1H NMR titration experiments are used to quantify the dimerization constants, as well as the association constant values of the 1:1 complexes formed between the receptors and a series of diamides and dipeptides. The receptors show moderate levels of selectivity in the molecular recognition of the hydrogen-bonding pattern present in the diamide series, selecting the α-amino acid-related hydrogen-bonding functionality. Only one of the two cyclic receptors shows modest signs of enantioselectivity and moderate diastereoselectivity in the recognition of the enantiomers and diastereoisomers of the Ala-Ala dipeptide (ΔΔG 0 1 (DD-DL) = −1.08 kcal/mol and ΔΔG 0 1 (DD-LD) = −0.89 kcal/mol). Surprisingly, the linear synthetic precursors show higher levels of stereoselectivity than their cyclic counterparts.

scholarly journals Design, synthesis, and pharmacology of some oxadiazole and hydroxypyrazoline hybrids bearing thiazoyl scaffold: antiproliferative activity, molecular docking and DNA binding studies

Heliyon ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e01255 ◽  
Author(s):  
Rangappa Santosh ◽  
Ashwini Prabhu ◽  
Mukunthan K. Selvam ◽  
Panchangam M. Krishna ◽  
Gundibasappa K. Nagaraja ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Binding ◽  
Antiproliferative Activity ◽  
Binding Studies ◽  
Design Synthesis ◽  
Dna Binding Studies

scholarly journals Hydrogen bond directed molecular recognition in water in a strapped-porphyrin-cyclodextrin assembly

2019 ◽  
Vol 23 (04n05) ◽  
pp. 569-574 ◽  
Author(s):  
Hiroaki Kitagishi ◽  
Kazuki Ohara ◽  
Daiki Shimoji ◽  
Maxime Vonesch ◽  
Jean Weiss ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Aqueous Medium ◽  
Essential Element ◽  
Water Soluble ◽  
Binding Studies ◽  
Zinc Porphyrin ◽  
Host Guest Complex ◽  
Binding Event ◽  
Comparative Binding ◽  
Protein Models

A water soluble, phenanthroline-strapped zinc porphyrin bearing four arylsulfonate groups formed a stable host–guest complex with two per-[Formula: see text]-methylated [Formula: see text]-cyclodextrin cavities. In the host–guest assembly, the zinc porphyrin was capable of binding imidazole within the cavity between the zinc(II) ion and the phenanthroline strap in an aqueous medium. The formation of a hydrogen bond between the imidazole NH and the nitrogen atoms of the phenanthroline was an essential element of the binding event, as shown by comparative binding studies with a non-strapped tetrasulfonated zinc porphyrin and with [Formula: see text]-methylimidazole. This hydrogen bonding in an aqueous medium was possible due to the protected hydrophobic environment created by the cyclodextrins around the phenanthroline strap. This type of binding event may provide a biomimetic approach to study water soluble heme protein models.

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