Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors

2010 ◽  
Vol 16 (30) ◽  
pp. 9123-9131 ◽  
Author(s):  
Xiaoming He ◽  
Fernando Herranz ◽  
Eddie Chung-Chin Cheng ◽  
Ramon Vilar ◽  
Vivian Wing-Wah Yam
Keyword(s):  
Anion Binding ◽  
Binding Studies ◽  
Design Synthesis ◽  
Thiolate Complexes

Calix[n]bipyrroles: Synthesis, Characterization, and Anion-Binding Studies

2003 ◽  
Vol 42 (20) ◽  
pp. 2278-2281 ◽  
Author(s):  
Jonathan L. Sessler ◽  
Deqiang An ◽  
Won-Seob Cho ◽  
Vincent Lynch
Keyword(s):  
Anion Binding ◽  
Binding Studies

Interactions of cobalt tetrasulfophthalocyanine with thiolate anions in dimethylformamide

2001 ◽  
Vol 05 (04) ◽  
pp. 405-414 ◽  
Author(s):  
EDUARD M. TYAPOCHKIN ◽  
EVGUENII I. KOZLIAK
Keyword(s):  
Axial Ligand ◽  
Anaerobic Conditions ◽  
Binding Studies ◽  
H Nmr ◽  
Dead End ◽  
End Products ◽  
Thiolate Complexes ◽  
Thiolate Anions ◽  
Equatorial Ligand ◽  
Phthalocyanine Ring

Thiolate complexes of cobalt tetrasulfophthalocyanine ( CoTSPc ), possible intermediates of the industrial removal of mercaptans from oil fractions (Merox process), were studied in dimethylformamide, dimethylsulfoxide, and other polar aprotic solvents by UV-vis, 1 H NMR, and ESR spectroscopy. All thiolates react with Co II TSPc under anaerobic conditions with 1:1 stoichiometry. All tested aliphatic thiolates, regardless of their basicity, reduce Co II TSPc to form Co I TSPc derivatives. Low-basicity thiolates also form unstable non-reduced ( RS -) Co II TSPc complexes as dead-end products. Indirect kinetic evidence was obtained for electron transfer from the axial ligand to metal via the phthalocyanine equatorial ligand. 1 H NMR and binding studies revealed sulfur–cobalt interactions in the Co I TSPc product, thus indicating an axial ligand attachment to Co I TSPc . Low-basicity aromatic thiolates (pentachloro- and pentafluorobenzenethiolate) form ( RS -) Co II TSPc complexes, which are stable toward intramolecular metal reduction. This effect is indicative of possible π-stacking between the aromatic thiolate and phthalocyanine ring.

Design, synthesis and binding studies of a novel quadruple ADDA hydrogen-bond array

2012 ◽  
Vol 10 (25) ◽  
pp. 4899 ◽  
Author(s):  
Maria L. Pellizzaro ◽  
Simon A. Barrett ◽  
Julie Fisher ◽  
Andrew J. Wilson
Keyword(s):  
Hydrogen Bond ◽  
Binding Studies ◽  
Design Synthesis

Design, Synthesis, and Binding Studies of New Potent Ligands of Cannabinoid Receptors

2005 ◽  
Vol 48 (23) ◽  
pp. 7343-7350 ◽  
Author(s):  
Antonella Brizzi ◽  
Vittorio Brizzi ◽  
Maria Grazia Cascio ◽  
Tiziana Bisogno ◽  
Rossella Sirianni ◽  
...  
Keyword(s):  
Cannabinoid Receptors ◽  
Binding Studies ◽  
Design Synthesis

scholarly journals Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides

2010 ◽  
Vol 6 ◽  
Author(s):  
Ana Maria Castilla ◽  
M Morgan Conn ◽  
Pablo Ballester
Keyword(s):  
Hydrogen Bonding ◽  
Peptide Ligands ◽  
Binding Studies ◽  
Design Synthesis ◽  
Macrocyclic Receptors ◽  
H Nmr ◽  
Hydrogen Bonding Pattern ◽  
Conformational Equilibria ◽  
Β Sheets ◽  
Β Sheet

We present here the design, synthesis, and analysis of a series of receptors for peptide ligands inspired by the hydrogen-bonding pattern of protein β-sheets. The receptors themselves can be regarded as strands 1 and 3 of a three-stranded β-sheet, with cross-linking between the chains through the 4-position of adjacent phenylalanine residues. We also report on the conformational equilibria of these receptors in solution as well as on their tendency to dimerize. 1H NMR titration experiments are used to quantify the dimerization constants, as well as the association constant values of the 1:1 complexes formed between the receptors and a series of diamides and dipeptides. The receptors show moderate levels of selectivity in the molecular recognition of the hydrogen-bonding pattern present in the diamide series, selecting the α-amino acid-related hydrogen-bonding functionality. Only one of the two cyclic receptors shows modest signs of enantioselectivity and moderate diastereoselectivity in the recognition of the enantiomers and diastereoisomers of the Ala-Ala dipeptide (ΔΔG 0 1 (DD-DL) = −1.08 kcal/mol and ΔΔG 0 1 (DD-LD) = −0.89 kcal/mol). Surprisingly, the linear synthetic precursors show higher levels of stereoselectivity than their cyclic counterparts.

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