Highly monodisperse rattle-structured nanomaterials with gold nanorod core–mesoporous silica shell as drug delivery vehicles and nanoreactors

Nanoscale ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 151-154 ◽  
Author(s):  
Eunjin Choi ◽  
Minjeong Kwak ◽  
Byungchul Jang ◽  
Yuanzhe Piao
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Shell ◽  
Gold Nanorod ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 742 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Delivery Vehicles ◽  
Biological Compatibility ◽  
Delivery Vehicles ◽  
Efficient Loading ◽  
Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

Mesoporous Silica-Coated Silver Nanoframes as Drug-Delivery Vehicles for Chemo/Starvation/Metal Ion Multimodality Therapy

Langmuir ◽  
2020 ◽  
Vol 36 (23) ◽  
pp. 6345-6351 ◽  
Author(s):  
Yu Zhang ◽  
Yaojia Li ◽  
Zhiguo Gao ◽  
Bowen Ding ◽  
Peijing An ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Ion ◽  
Multimodality Therapy ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Hollow silica capsules for amphiphilic transport and sustained delivery of antibiotic and anticancer drugs

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 24883-24892 ◽  
Author(s):  
Isabel Gessner ◽  
Eva Krakor ◽  
Anna Jurewicz ◽  
Veronika Wulff ◽  
Lasse Kling ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Sustained Release ◽  
Anticancer Drugs ◽  
Sustained Delivery ◽  
Hollow Silica ◽  
Drug Delivery Vehicles ◽  
Amphiphilic Drug ◽  
Delivery Vehicles ◽  
Hollow Mesoporous Silica

Hollow mesoporous silica capsules were used as amphiphilic drug delivery vehicles and sustained release systems for antimicrobial and anticancer drugs.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

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