scholarly journals Hollow silica capsules for amphiphilic transport and sustained delivery of antibiotic and anticancer drugs

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 24883-24892 ◽  
Author(s):  
Isabel Gessner ◽  
Eva Krakor ◽  
Anna Jurewicz ◽  
Veronika Wulff ◽  
Lasse Kling ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Sustained Release ◽  
Anticancer Drugs ◽  
Sustained Delivery ◽  
Hollow Silica ◽  
Drug Delivery Vehicles ◽  
Amphiphilic Drug ◽  
Delivery Vehicles ◽  
Hollow Mesoporous Silica

Hollow mesoporous silica capsules were used as amphiphilic drug delivery vehicles and sustained release systems for antimicrobial and anticancer drugs.

scholarly journals Encapsulation of Hydrophobic Drugs in Shell-by-Shell Coated Nanoparticles for Radio—and Chemotherapy—An In Vitro Study

2020 ◽  
Vol 7 (4) ◽  
pp. 126
Author(s):  
Stefanie Klein ◽  
Tobias Luchs ◽  
Andreas Leng ◽  
Luitpold Distel ◽  
Winfried Neuhuber ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Double Layer ◽  
Oxide Surface ◽  
Al2o3 Nanoparticles ◽  
X Rays ◽  
Hydrophobic Drugs ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Mcf 7

Our research objective was to develop novel drug delivery vehicles consisting of TiO2 and Al2O3 nanoparticles encapsulated by a bilayer shell that allows the reversible embedment of hydrophobic drugs. The first shell is formed by covalent binding of hydrophobic phosphonic acid at the metal oxide surface. The second shell composed of amphiphilic sodium dodecylbenzenesulfonate emerges by self-aggregation driven by hydrophobic interactions between the dodecylbenzene moiety and the hydrophobic first shell. The resulting double layer provides hydrophobic pockets suited for the intake of hydrophobic drugs. The nanoparticles were loaded with the anticancer drugs quercetin and 7-amino-4-methylcoumarin. Irradiation with X-rays was observed to release the potential anticancer drugs into the cytoplasm. In Michigan Cancer Foundation (MCF)-10 A cells, quercetin and 7-amino-4-methylcoumarin acted as antioxidants by protecting the non-tumorigenic cells from harmful radiation effects. In contrast, these agents increased the reactive oxygen species (ROS) formation in cancerous MCF-7 cells. Quercetin and 7-amino-4-methylcoumarin were shown to induce apoptosis via the mitochondrial pathway in cancer cells by determining an increase in TUNEL-positive cells and a decrease in mitochondrial membrane potential after irradiation. After X-ray irradiation, the survival fraction of MCF-7 cells with drug-loaded nanoparticles considerably decreased, which demonstrates the excellent performance of the double-layer stabilized nanoparticles as drug delivery vehicles.

Hollow Silica Nanocontainers as Drug Delivery Vehicles

Langmuir ◽  
2008 ◽  
Vol 24 (7) ◽  
pp. 3417-3421 ◽  
Author(s):  
Jaemoon Yang ◽  
Jaewon Lee ◽  
Jinyoung Kang ◽  
Kwangyeol Lee ◽  
Jin-Suck Suh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hollow Silica ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Mixed micellization of dimeric surfactant–amphiphilic drug systems: effect of surfactant structure

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 20324-20336 ◽  
Author(s):  
Andleeb Z. Naqvi ◽  
Sahar Noori ◽  
Kabir-ud-Din Kabir-ud-Din
Keyword(s):  
Drug Delivery ◽  
Aqueous Solutions ◽  
Mixed Micellization ◽  
Drug Delivery Vehicles ◽  
Amphiphilic Drug ◽  
Imipramine Hydrochloride ◽  
Delivery Vehicles ◽  
Dimeric Surfactant ◽  
Dimeric Surfactants

For their applications as drug delivery vehicles, the mixed interfacial/micellar behaviour of zwitterionic, cocogem and anionic dimeric surfactants with an amphiphilic drug imipramine hydrochloride in aqueous solutions has been investigated.

scholarly journals Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

RSC Advances ◽  
2021 ◽  
Vol 11 (36) ◽  
pp. 22057-22069
Author(s):  
Pooja Prasanthan ◽  
Nand Kishore
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Triblock Copolymers ◽  
Target Protein ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Micelles formed by pluronic triblock copolymers are known to be a promising class of drug delivery vehicles.

scholarly journals Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 742 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Delivery Vehicles ◽  
Biological Compatibility ◽  
Delivery Vehicles ◽  
Efficient Loading ◽  
Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

Mesoporous Silica-Coated Silver Nanoframes as Drug-Delivery Vehicles for Chemo/Starvation/Metal Ion Multimodality Therapy

Langmuir ◽  
2020 ◽  
Vol 36 (23) ◽  
pp. 6345-6351 ◽  
Author(s):  
Yu Zhang ◽  
Yaojia Li ◽  
Zhiguo Gao ◽  
Bowen Ding ◽  
Peijing An ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Ion ◽  
Multimodality Therapy ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles
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