Effect of cationic side-chains on intracellular delivery and cytotoxicity of pH sensitive polymer–doxorubicin nanocarriers

Nanoscale ◽  
2012 ◽  
Vol 4 (22) ◽  
pp. 7012 ◽  
Author(s):  
Chen Fang ◽  
Forrest M. Kievit ◽  
Yong-Chan Cho ◽  
Hyejung Mok ◽  
Oliver W. Press ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Ph Sensitive ◽  
Side Chains ◽  
Ph Sensitive Polymer

scholarly journals pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery

Biomaterials ◽  
2019 ◽  
Vol 192 ◽  
pp. 235-244 ◽  
Author(s):  
David J. Peeler ◽  
Salina N. Thai ◽  
Yilong Cheng ◽  
Philip J. Horner ◽  
Drew L. Sellers ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Ph Sensitive ◽  
Polymer Micelles ◽  
Venom Peptides ◽  
Ph Sensitive Polymer

scholarly journals Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Soft Matter ◽  
2017 ◽  
Vol 13 (41) ◽  
pp. 7571-7577 ◽  
Author(s):  
Monika Kluzek ◽  
Arwen I. I. Tyler ◽  
Shiqi Wang ◽  
Rongjun Chen ◽  
Carlos M. Marques ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Submicron Size ◽  
Cubic Phases ◽  
Bicontinuous Cubic ◽  
Ph Sensitive Polymer

Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers.

In VivoEvaluation of pH-Sensitive Polymer-Based Immunoliposomes Targeting the CD33 Antigen

2010 ◽  
Vol 7 (4) ◽  
pp. 1098-1107 ◽  
Author(s):  
Pierre Simard ◽  
Jean-Christophe Leroux
Keyword(s):  
Ph Sensitive ◽  
Ph Sensitive Polymer

scholarly journals INHIBITION OF GASTRIC DEGRADATION OF OMEPRAZOLE USING A pH-SENSITIVE POLYMER AS A BINDER IN TABLET FORMULATION

2021 ◽  
pp. 331-335
Author(s):  
EMMANUEL O. OLORUNSOLA ◽  
IMO E. UDOH ◽  
STEPHEN O. MAJEKODUNMI ◽  
INIOBONG J. ODIONG ◽  
UWAKMFON O. EBONG
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Ph Sensitive ◽  
Tablet Formulation ◽  
Direct Compression ◽  
Dissolution Medium ◽  
Ultraviolet Spectrophotometry ◽  
Substantial Inhibition ◽  
Ph Sensitive Polymer

Objective: This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug. Methods: Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the batches labelled F1 to F6 respectively. A batch containing 15% hydroxypropyl methylcellulose (F7) was also formulated. The tablets were characterized; and dissolution in a pH 1.2 dissolution medium over 120 min period was studied. Aliquots taken every 20 min were analyzed by ultraviolet spectrophotometry to determine the amount of drug released and not degraded. Results: Amounts of drug released and not degraded at time 120 min were 53.1%, 57.3%, 57.8%, 58.8%, 62.1%, 83.4% and 90.0% for F1 to F7 respectively. Conclusion: Afzelia gum at a concentration of 30% is suitable for use as a binder in tablet formulation of omeprazole to ensure substantial inhibition of gastric degradation of the drug.

scholarly journals Fabrication of potentiometric enzyme sensors based on a pH-sensitive polymer-coated Ag electrode.

1987 ◽  
Vol 35 (11) ◽  
pp. 4568-4573 ◽  
Author(s):  
JUN-ICHI ANZAI ◽  
MASAHIKO SHIMADA ◽  
HONGDA Fu ◽  
TETSUO OSA
Keyword(s):  
Ph Sensitive ◽  
Ag Electrode ◽  
Enzyme Sensors ◽  
Ph Sensitive Polymer

pH-Sensitive Polymer Conjugates for Anticorrosion and Corrosion Sensing

2018 ◽  
Vol 10 (24) ◽  
pp. 20876-20883 ◽  
Author(s):  
Naruphorn Dararatana ◽  
Farzad Seidi ◽  
Daniel Crespy
Keyword(s):  
Ph Sensitive ◽  
Polymer Conjugates ◽  
Ph Sensitive Polymer
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