Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy

Nanoscale ◽  
2012 ◽  
Vol 4 (19) ◽  
pp. 6050 ◽  
Author(s):  
Haiyan Chen ◽  
Shulan Li ◽  
Bowen Li ◽  
Xueyan Ren ◽  
Shengnan Li ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Gold Nanoclusters

scholarly journals Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging

2019 ◽  
Vol 95 (5) ◽  
pp. 475-489
Author(s):  
Mona Doshi ◽  
Daniel A. Nierenberg ◽  
Orielyz Flores-Fernandez ◽  
Pragney Deme ◽  
Edilu Becerra ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Tumor Imaging

Glucose-functionalized near-infrared Ag2Se quantum dots with renal excretion ability for long-term in vivo tumor imaging

2019 ◽  
Vol 7 (38) ◽  
pp. 5782-5788 ◽  
Author(s):  
Xiao-Lei Ge ◽  
Biao Huang ◽  
Zhi-Ling Zhang ◽  
Xiaolan Liu ◽  
Man He ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Renal Excretion ◽  
Tumor Imaging

Non-toxic and long-term fluorescent probes for tumor imaging are in urgent need for non-invasively obtaining information about tumor genesis and metastasis in vivo.

scholarly journals Glucosamine-Bound Near-Infrared Fluorescent Probes with Lysosomal Specificity for Breast Tumor Imaging

Neoplasia ◽  
2008 ◽  
Vol 10 (4) ◽  
pp. 389-398 ◽  
Author(s):  
Cong Li ◽  
Tiffany R. Greenwood ◽  
Kristine Glunde
Keyword(s):  
Fluorescent Probes ◽  
Breast Tumor ◽  
Near Infrared ◽  
Tumor Imaging

scholarly journals Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaojing Shi ◽  
Caiguang Cao ◽  
Zeyu Zhang ◽  
Jie Tian ◽  
Zhenhua Hu
Keyword(s):  
Fluorescent Probes ◽  
Signal Intensity ◽  
Tumor Imaging ◽  
Tumor Resection ◽  
Optical Signal ◽  
Gadolinium Oxide ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
The Impact

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24 ± 2.24 vs. 1.87 ± 0.73, P = 0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

2021 ◽  
Author(s):  
Xiao Liu ◽  
Xiangyang Gong ◽  
Jie Yuan ◽  
Xiaopeng Fan ◽  
Xingxing Zhang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Stimulus Responsive

scholarly journals Detection of cell surface calreticulin as a potential cancer biomarker using near-infrared emitting gold nanoclusters

2016 ◽  
Vol 27 (28) ◽  
pp. 285101 ◽  
Author(s):  
Bala Subramaniyam Ramesh ◽  
Emmanouil Giorgakis ◽  
Victor Lopez-Davila ◽  
Ashkan Kamali Dashtarzheneha ◽  
Marilena Loizidou
Keyword(s):  
Cell Surface ◽  
Near Infrared ◽  
Gold Nanoclusters ◽  
Cancer Biomarker ◽  
Potential Cancer
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