scholarly journals Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype

Metallomics ◽  
2012 ◽  
Vol 4 (11) ◽  
pp. 1167 ◽  
Author(s):  
Mohammad Bakhtiar Hossain ◽  
Marie Vahter ◽  
Gabriela Concha ◽  
Karin Broberg
Keyword(s):  
Dna Methylation ◽  
Dna Repair ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Arsenic Exposure ◽  
Suppressor Gene ◽  
Repair Gene ◽  
Arsenic Metabolism ◽  
Dna Repair Gene

Abstract A18: Expression of the tumor suppressor gene RARRES1 in the differentiation hierarchy of breast cancer is regulated by DNA methylation

2016 ◽  
Author(s):  
Krysta Mila Coyle ◽  
Dejan Vidovic ◽  
Cheryl A. Dean ◽  
Margaret Lois Thomas ◽  
Mohammad Sultan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

scholarly journals Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation

Oncogene ◽  
2005 ◽  
Vol 24 (41) ◽  
pp. 6249-6255 ◽  
Author(s):  
Sabine Zöchbauer-Müller ◽  
Kwun M Fong ◽  
Joseph Geradts ◽  
Xie Xu ◽  
Sonja Seidl ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Lung Cancers ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

Cancer Cell ◽  
2003 ◽  
Vol 3 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Kurtis E Bachman ◽  
Ben Ho Park ◽  
Ina Rhee ◽  
Harith Rajagopalan ◽  
James G Herman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Histone Modifications ◽  
Suppressor Gene

scholarly journals DNA Hypermethylation Modification Promotes the Development of Hepatocellular Carcinoma by Depressing the Tumor Suppressor Gene ZNF334

2021 ◽  
Author(s):  
Da-peng Sun ◽  
Xiao-jie Gan ◽  
Lei Liu ◽  
Yuan Yang ◽  
Dong-yang Ding ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Tumor Suppressor ◽  
Liver Cancer ◽  
Tumor Suppressor Gene ◽  
Clinical Evidence ◽  
Early Stage ◽  
Suppressor Gene ◽  
Dna Hypermethylation ◽  
Dysplastic Nodules

Abstract Background: DNA methylation plays a pivotal role in the development and progression of tumors, but studies focused on the dynamic changes of DNA methylation in the development of hepatocellular carcinoma (HCC) are rare. This manuscript is aimed to construct pre- and early DNA methylation maps of liver cancer of the same genetic background, as well as to reveal the mechanism of epigenetics regulating gene expression during the development of liver cancer, thus providing new targets and clinical evidence for early diagnosis and shedding lights on the precise treatment for liver cancer. Methods: The study includes 5 patients who were chronic hepatitis B virus infected, clinically diagnosed as primary liver cancer and pathologically diagnosed as early liver cancer with liver dysplastic nodules. Liver fibrosis tissues, dysplastic nodules and early HCC tissues from these patients have been used to measure DNA methylation. Results: We report significant differences in the DNA methylation spectrum of three types of tissues. In the early stage of HCC, DNA hypermethylation of tumor suppressor genes is predominant. Additionally, DNA hypermethylation in the early stage of HCC changes the binding of transcription factor P53 to the promoter of tumor suppressor gene ZNF334, and inhibits the expression of ZNF334 at the transcription level. Furthermore, through a series of in vivo and in vitro experiments, we have clarified the exacerbation effect of tumor suppressor gene ZNF334 deletion in the occurrence of HCC. Combined with clinical data, we found that the overall survival and disease-free survival of patients with high ZNF334 expression are longer than the lower one. Conclusions: We constructed a sequential map of DNA methylation modification during the occurrence of HCC, and clarified the biological function and regulatory mechanism of the tumor suppressor gene ZNF334, which is regulated by related DNA methylation sites, and also provide new targets and clinical evidence for the early diagnosis and precise treatment of liver cancer.

scholarly journals DNA methylation analysis of the tumor suppressor gene CDKN2B in Brazilian leukemia patients

2008 ◽  
Vol 31 (3) ◽  
pp. 632-638 ◽  
Author(s):  
Patrícia Santos Pereira Lima ◽  
Greice Andreoti Molffeta ◽  
Amélia Góes de Araujo ◽  
Marco Antônio Zago ◽  
Wilson Araújo da Silva Jr.
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Methylation Analysis ◽  
Dna Methylation Analysis
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