scholarly journals DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells

2016 ◽  
Vol 186 (7) ◽  
pp. 1967-1976 ◽  
Author(s):  
Peter A. Mollica ◽  
John A. Reid ◽  
Roy C. Ogle ◽  
Patrick C. Sachs ◽  
Robert D. Bruno
Keyword(s):  
Dna Methylation ◽  
Dna Repair ◽  
Huntington Disease ◽  
Trinucleotide Repeat ◽  
Repeat Expansion ◽  
Trinucleotide Repeat Expansion ◽  
Down Regulation ◽  
Repair Gene ◽  
Dna Repair Gene

Analysis of the trinucleotide repeat expansion in Italian families affected with Huntington disease

1994 ◽  
Vol 3 (1) ◽  
pp. 93-98 ◽  
Author(s):  
A. Novelletto ◽  
F. Persichetti ◽  
G. Sabbadin ◽  
P. Mandich ◽  
E. Bellone ◽  
...  
Keyword(s):  
Huntington Disease ◽  
Trinucleotide Repeat ◽  
Repeat Expansion ◽  
Trinucleotide Repeat Expansion

A PCR method for accurate assessment of trinucleotide repeat expansion in Huntington disease

1993 ◽  
Vol 2 (6) ◽  
pp. 635-636 ◽  
Author(s):  
Y.Paul Goldberg ◽  
Susan E. Andrew ◽  
Lorne A. Clarke ◽  
Michael R. Hayden
Keyword(s):  
Huntington Disease ◽  
Trinucleotide Repeat ◽  
Repeat Expansion ◽  
Accurate Assessment ◽  
Trinucleotide Repeat Expansion ◽  
Pcr Method

Repair of base–base mismatches in simian and human cells

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 578-583 ◽  
Author(s):  
Thomas C. Brown ◽  
Josef Jiricny
Keyword(s):  
Dna Methylation ◽  
Dna Repair ◽  
Gene Conversion ◽  
Human Fibroblasts ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Flanking Sequences ◽  
Sv40 Dna ◽  
Derivatives Of ◽  
Genetic Events

Mismatched heteroduplexes arise as intermediates of several dissimilar genetic processes. The outcome of these genetic events will therefore be influenced by the efficiency and specificity of mismatch repair. We have studied the correction of base–base mispairs in simian and human fibroblasts by transfecting the cells with derivatives of SV40 DNA, each harboring a single mispair in a defined orientation. Analysis of plaques revealed that correction efficiencies for homomispairs followed the pattern G∙G > C∙C ≥ A∙A > T∙T. Repair bias was influenced by flanking sequences. Correction efficiencies for heteromispairs followed the pattern of G∙T > A∙C > C∙T > A∙G and repair favored the retention of G+C by a substantial margin. This repair specificity could lead to a gene conversion bias favoring the accumulation of G+C in sequences subject to high levels of recombination or unequal exchange.Key words: DNA repair, gene conversion, recombination, DNA methylation.

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