Synthesis, radical scavenging activity and structure–activity relationship of uric acid analogs

MedChemComm ◽  
2013 ◽  
Vol 4 (3) ◽  
pp. 527 ◽  
Author(s):  
Daisuke Yasuda ◽  
Kyoko Takahashi ◽  
Tomohiro Kakinoki ◽  
Yoko Tanaka ◽  
Tomoyuki Ohe ◽  
...  
Keyword(s):  
Uric Acid ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Scavenging Activity ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Antioxidant Activity of 1’-Hydroxyethylnaphthazarins and their Derivatives

2017 ◽  
Vol 12 (12) ◽  
pp. 1934578X1701201
Author(s):  
Natalia K. Utkina ◽  
Natalia D. Pokhilo
Keyword(s):  
Antioxidant Activity ◽  
Radical Cation ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Hydroxyl Group ◽  
Side Chains ◽  
Scavenging Activity ◽  
Structure Activity

The ABTS•+ radical cation scavenging activity of known (2-5, 9, 10) and new (6-8) 1’-hydroxyethylnaphthazarins and their products of esterification and etherification was evaluated and a structure-activity relationship was studied. It was shown, that the structure of side chains does not affect the radical scavenging activity of 1’-hydroxyethylnaphthazarins and their derivatives. The presence of methoxyl groups on the naphthazarin core slightly enhanced the antioxidant activity of compounds compared with compounds without methoxyl groups. The presence of the additional hydroxyl group on the naphthazarin moiety of isonorlomazarin (5) and its derivative (6) is essential for the activity.

scholarly journals Antioxidant and Chemosensitizing Effects of Flavonoids with Hydroxy and/or Methoxy Groups and Structure-Activity Relationship

2007 ◽  
Vol 10 (4) ◽  
pp. 537 ◽  
Author(s):  
Ju-Mi Jeong ◽  
Cheol-Hee Choi ◽  
Su-Kyeong Kang ◽  
In-Hwa Lee ◽  
Ji-Yoon Lee ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Oh Groups ◽  
Structure Activity ◽  
P Glycoprotein ◽  
Ic50 Values

Purpose. Flavonoids have been used as antioxidant, chemopreventive and chemosensitizing agents. In this study, eleven flavonoids containing a variety of hydroxy (OH) and/or methoxy (OMe) groups were evaluated for their antioxidant, cytotoxic and chemosensitizing effects to create a structure-activity relationship (SAR). Methods. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical solution-based chemical assay and and 2',7'-dichlorofluorescin diacetate (DCFH-DA) cellular-based assay were used to compare the free radical scavenging activity on the same molar concentration basis using the AML-2/DX100 cells which are characterized by the down-regulated expression of catalase and resulting supersensitiviy to hydrogen peroxide. The chemosensitization and cytotoxicity were determined by the MTT assay in the presence or absence of an anticancer drug using the P-glycoprotein-overexpressing AML-2 subline AML-2/D100 cells. Results. The antioxidant activity of the flavonoid (3,5,7,3’,4’-OH) was higher than that of the flavonoid (5,7,3’,4’-OH). Flavonoids substituted with the various number of OMe decreased antioxidant activity. Flavonoids with 7-OH or 5,7-OH groups have the highest cytotoxicity, and flavonoids with 5,7-OMe group intermediate cytotoxicity. The IC50 values of flavonoid (5,7-OMe, 3’,4’,5’-OMe) and flavonoid (5,7-OMe, 4’-OMe), 0.4 M and 1.4 M. The IC50 values of flavonoid (5,6,7-OMe, 3’,4’-OMe) and flavonoid (5,6,7-OMe, 3’,4’,5’-OMe), 3.2 uM and 0.9 M, respectively, and those of flavonoid (5,6,7-OMe, 3’,4’,5’-OMe) and flavonoid (5,7-OMe,3’,4’,5’-OMe) were 0.9 M and 0.4 M, respectively. Conclusions. These results suggest that flavonoids with 3-OH group play a positive role in antioxidant activities, flavonoids with 5-OH and/or 7-OH groups show the higher cytotoxicity, and flavonoids with 3’-OMe and/or 5’-OMe groups plays positive but 6-OMe groups negative roles in the P-glycoprotein (Pgp) inhibition. It is believed that these SAR results can be taken into account for the development of flavonoids with high therapeutic index.

Structure-activity relationship of flavonoids with superoxide scavenging activity

1995 ◽  
Vol 47 (1-3) ◽  
pp. 327-331 ◽  
Author(s):  
J. P. Hu ◽  
M. Calomme ◽  
A. Lasure ◽  
T. De Bruyne ◽  
L. Pieters ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Scavenging Activity ◽  
Superoxide Scavenging Activity ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Correction: Analysis of the quantitative structure–activity relationship of glutathione-derived peptides based on different free radical scavenging systems

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2193-2193
Author(s):  
Wenzhen Liao ◽  
Longjian Gu ◽  
Yamei Zheng ◽  
Zisheng Zhu ◽  
Mouming Zhao ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Quantitative Structure Activity Relationship ◽  
Structure Activity Relationship ◽  
Free Radical Scavenging ◽  
Activity Relationship ◽  
Quantitative Structure ◽  
Structure Activity ◽  
Relationship Of

Correction for ‘Analysis of the quantitative structure–activity relationship of glutathione-derived peptides based on different free radical scavenging systems’ by Wenzhen Liao et al., Med. Chem. Commun., 2016, DOI: 10.1039/c6md00006a.

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