Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic conditions

2013 ◽  
Vol 9 (2) ◽  
pp. 285-295 ◽  
Author(s):  
Aram Kang ◽  
Mui Hua Tan ◽  
Hua Ling ◽  
Matthew Wook Chang
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Stress Tolerance ◽  
Anaerobic Conditions ◽  
Oxidative Stress Tolerance

Synechocystis Fe superoxide dismutase gene confers oxidative stress tolerance to Escherichia coli

2004 ◽  
Vol 316 (2) ◽  
pp. 540-544 ◽  
Author(s):  
Jyotirmoy Bhattacharya ◽  
Krishnarup GhoshDastidar ◽  
Anirban Chatterjee ◽  
Manoj Majee ◽  
Arun Lahiri Majumder
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Superoxide Dismutase ◽  
Stress Tolerance ◽  
Oxidative Stress Tolerance ◽  
Superoxide Dismutase Gene

scholarly journals Elimination of GlnKAmtB affects serine biosynthesis and improves growth and stress tolerance of Escherichia coli under nutrient-rich conditions

2020 ◽  
Vol 367 (23) ◽  
Author(s):  
Romina Frare ◽  
Margarita Stritzler ◽  
Cecilia Pascuan ◽  
Karen Liebrenz ◽  
Luisa Galindo-Sotomonte ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Growth Rate ◽  
Stress Tolerance ◽  
Citrate Synthase ◽  
Ammonium Uptake ◽  
Uptake System ◽  
Oxidative Stress Tolerance ◽  
The Impact ◽  
Serine Biosynthesis

ABSTRACT Nitrogen is a most important nutrient resource for Escherichia coli and other bacteria that harbor the glnKamtB operon, a high-affinity ammonium uptake system highly interconnected with cellular metabolism. Although this system confers an advantage to bacteria when growing under nitrogen-limiting conditions, little is known about the impact of these genes on microbial fitness under nutrient-rich conditions. Here, the genetically tractable E. coli BW25113 strain and its glnKamtB-null mutant (JW0441) were used to analyze the impact of GlnK-AmtB on growth rates and oxidative stress tolerance. Strain JW0441 showed a shorter initial lag phase, higher growth rate, higher citrate synthase activity, higher oxidative stress tolerance and lower expression of serA than strain BW25113 under nutrient-rich conditions, suggesting a fitness cost to increase metabolic plasticity associated with serine metabolism. The overexpression of serA in strain JW0441 resulted in a decreased growth rate and stress tolerance in nutrient-rich conditions similar to that of strain BW25113, suggesting that the negative influence on bacterial fitness imposed by GlnK-AmtB can be traced to the control of serine biosynthesis. Finally, we discuss the potential applications of glnKamtB mutants in bioproduction processes.

scholarly journals Hydrogen peroxide priming modulates abiotic oxidative stress tolerance: insights from ROS detoxification and scavenging

2015 ◽  
Vol 6 ◽  
Author(s):  
Mohammad A. Hossain ◽  
Soumen Bhattacharjee ◽  
Saed-Moucheshi Armin ◽  
Pingping Qian ◽  
Wang Xin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Stress Tolerance ◽  
Oxidative Stress Tolerance
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