Modification of calcium carbonate based gene and drug delivery systems by a cell-penetrating peptide

2012 ◽  
Vol 8 (12) ◽  
pp. 3288 ◽  
Author(s):  
Dong Zhao ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems

2013 ◽  
Vol 19 (4) ◽  
pp. 182-189 ◽  
Author(s):  
João Miguel Freire ◽  
Ana Salomé Veiga ◽  
Beatriz G. de la Torre ◽  
David Andreu ◽  
Miguel A. R. B. Castanho
Keyword(s):  
Drug Delivery ◽  
Lipid Membranes ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Supramolecular Complexes ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery

Drug Delivery ◽  
2019 ◽  
Vol 27 (1) ◽  
pp. 91-99
Author(s):  
Jingjing Song ◽  
Sujie Huang ◽  
Zhengzheng Zhang ◽  
Bo Jia ◽  
Huan Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell ◽  
Peptide Antagonist

scholarly journals Application of calcium carbonate nanocarriers for controlled release of phytodrugs against Xylella fastidiosa pathogen

2020 ◽  
Vol 92 (3) ◽  
pp. 429-444 ◽  
Author(s):  
Francesca Baldassarre ◽  
Angelo De Stradis ◽  
Giuseppe Altamura ◽  
Viviana Vergaro ◽  
Cinzia Citti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Xylella Fastidiosa ◽  
Delivery Systems ◽  
In Planta ◽  
Potential Control ◽  
Antimicrobial Substances ◽  
Olive Quick Decline Syndrome

AbstractCalcium carbonate-based hollow or porous particles are one of the preferred carriers for fabrication of drug delivery systems. We have developed an eco-friendly method to produce calcium carbonate nanocrystals, which have shown biocompatibility and optimal capacity to across cell membrane in human cell lines providing new tools in cancer therapy. The success of drug delivery systems has paved the way for the development of systems for controlled release of agrochemicals. In this work, we exploited calcium carbonate nanocrystals as carriers for targeted release of phytodrugs investigating a potential control strategy for the pathogen Xylella fastidiosa. This pathogen is the causal agent of the Olive Quick Decline Syndrome that is an unprecedented emergency in Italy and potentially in the rest of Europe. We studied nanocrystals interactions with bacteria cells and the application in planta to verify olive plants uptake. Ultrastructural analysis by electron microscopy shown an alteration of bacteria wall following nanocrystals interaction. Nanocrystals were adsorbed from roots and they translocated in plants tissues. Calcium carbonate carriers were able to encapsulate efficiently two types of antimicrobial substances and the potential efficacy was tested in experiment under greenhouse conditions.

Dual-functionalized calcium carbonate based gene delivery system for efficient gene delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38623-38629 ◽  
Author(s):  
Chao-Qun Wang ◽  
Meng-Qing Gong ◽  
Jin-Long Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Calcium Carbonate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Dna Nanoparticles ◽  
Efficient Gene ◽  
Cell Penetrating ◽  
A Cell

Dual-functionalized KALA/PS/CaCO3/DNA nanoparticles containing a cell penetrating peptide (KALA) and protamine sulfate (PS) could effectively mediate gene transfection at a low DNA concentration.

scholarly journals Cell-penetrating TAT peptide in drug delivery systems: Proteolytic stability requirements

Drug Delivery ◽  
2011 ◽  
Vol 18 (5) ◽  
pp. 377-384 ◽  
Author(s):  
Erez Koren ◽  
Anjali Apte ◽  
Rupa R. Sawant ◽  
Jacob Grunwald ◽  
Vladimir P. Torchilin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Tat Peptide ◽  
Cell Penetrating ◽  
Proteolytic Stability

Highly-magnetic mineral protein-tannin vehicles with anti-breast cancer activity

2021 ◽  
Author(s):  
Polina Demina ◽  
Anatolii Abalymov ◽  
Denis V. Voronin ◽  
Alexander V. Sadovnikov ◽  
Maria Vladimirovna Lomova
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Calcium Carbonate ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Saturation Level ◽  
Submicron Particles ◽  
Magnetic Mineral ◽  
Cancer Activity

Anticancer hybrid mineral highly-magnetic protein-tannin vehicles are tunable and controllable external triggers for drug delivery systems. The saturation level of submicron particles of calcium carbonate with magnetic nanoparticles was achieved....

scholarly journals Chiral Cyclobutane-Containing Cell-Penetrating Peptides as Selective Vectors for Anti-Leishmania Drug Delivery Systems

2020 ◽  
Vol 21 (20) ◽  
pp. 7502
Author(s):  
Ona Illa ◽  
José-Antonio Olivares ◽  
Nerea Gaztelumendi ◽  
Laura Martínez-Castro ◽  
Jimena Ospina ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Cell Penetrating Peptides ◽  
Delivery Systems ◽  
Conformational Structure ◽  
Intracellular Accumulation ◽  
Standard Drug ◽  
Cell Line Hela ◽  
Computational Calculations ◽  
Cell Penetrating

Two series of new hybrid γ/γ-peptides, γ-CC and γ-CT, formed by (1S,2R)-3-amino-2,2,dimethylcyclobutane-1-carboxylic acid joined in alternation to a Nα-functionalized cis- or trans-γ-amino-l-proline derivative, respectively, have been synthesized and evaluated as cell penetrating peptides (CPP) and as selective vectors for anti-Leishmania drug delivery systems (DDS). They lacked cytotoxicity on the tumoral human cell line HeLa with a moderate cell-uptake on these cells. In contrast, both γ-CC and γ-CT tetradecamers were microbicidal on the protozoan parasite Leishmania beyond 25 μM, with significant intracellular accumulation. They were conjugated to fluorescent doxorubicin (Dox) as a standard drug showing toxicity beyond 1 μM, while free Dox was not toxic. Intracellular accumulation was 2.5 higher than with Dox-TAT conjugate (TAT = transactivator of transcription, taken as a standard CPP). The conformational structure of the conjugates was approached both by circular dichroism spectroscopy and molecular dynamics simulations. Altogether, computational calculations predict that the drug-γ-peptide conjugates adopt conformations that bury the Dox moiety into a cavity of the folded peptide, while the positively charged guanidinium groups face the solvent. The favorable charge/hydrophobicity balance in these CPP improves the solubility of Dox in aqueous media, as well as translocation across cell membranes, making them promising candidates for DDS.

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