Rapid-prototyped collagen scaffolds reinforced with PCL/β-TCP nanofibres to obtain high cell seeding efficiency and enhanced mechanical properties for bone tissue regeneration

2012 ◽  
Vol 22 (33) ◽  
pp. 16880 ◽  
Author(s):  
Yong Bok Kim ◽  
GeunHyung Kim
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Cell Seeding ◽  
High Cell ◽  
Collagen Scaffolds ◽  
Seeding Efficiency

A highly bioactive and biodegradable poly(glycerol sebacate)–silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration

2015 ◽  
Vol 3 (16) ◽  
pp. 3222-3233 ◽  
Author(s):  
Xin Zhao ◽  
Yaobin Wu ◽  
Yuzhang Du ◽  
Xiaofeng Chen ◽  
Bo Lei ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Silica Glass ◽  
Bone Tissue Regeneration ◽  
Biodegradable Poly

A highly bioactive and biodegradable PGS–Silica bioactive glass hybrid elastomer with tailored mechanical properties was developed for bone tissue regeneration application.

scholarly journals Bone Regeneration in Critical-Sized Bone Defects Treated with Additively Manufactured Porous Metallic Biomaterials: The Effects of Inelastic Mechanical Properties

Materials ◽  
2020 ◽  
Vol 13 (8) ◽  
pp. 1992
Author(s):  
Marianne Koolen ◽  
Saber Amin Yavari ◽  
Karel Lietaert ◽  
Ruben Wauthle ◽  
Amir A. Zadpoor ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bulk Material ◽  
Bone Tissue Regeneration ◽  
Bony Tissue ◽  
Metallic Biomaterials ◽  
Cp Ti ◽  
Porous Biomaterials

Additively manufactured (AM) porous metallic biomaterials, in general, and AM porous titanium, in particular, have recently emerged as promising candidates for bone substitution. The porous design of such materials allows for mimicking the elastic mechanical properties of native bone tissue and showed to be effective in improving bone regeneration. It is, however, not clear what role the other mechanical properties of the bulk material such as ductility play in the performance of such biomaterials. In this study, we compared the bone tissue regeneration performance of AM porous biomaterials made from the commonly used titanium alloy Ti6Al4V-ELI with that of commercially pure titanium (CP-Ti). CP-Ti was selected because of its high ductility as compared to Ti6Al4V-ELI. Critical-sized (6 mm diameter) femoral defects in rats were treated with implants made from both Ti6Al4V-ELI and CP-Ti. Bone regeneration was assessed up to 11 weeks using micro-CT scanning. The regenerated bone volume was assessed ex vivo followed by histology and biomechanical testing to assess osseointegration of the implants. The bony defects treated with AM CP-Ti implants generally showed higher volumes of regenerated bone as compared to those treated with AM Ti6Al4V-ELI. The torsional strength of the two titanium groups were similar however, and both considerably lower than those measured for intact bony tissue. These findings show the importance of material type and ductility of the bulk material in the ability for bone tissue regeneration of AM porous biomaterials.

scholarly journals Fabrication of High-Strength and Porous Hybrid Scaffolds Based on Nano-Hydroxyapatite and Human-Like Collagen for Bone Tissue Regeneration

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 61 ◽  
Author(s):  
Yannan Liu ◽  
Juan Gu ◽  
Daidi Fan
Keyword(s):  
Mechanical Properties ◽  
Enzymatic Hydrolysis ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Repair ◽  
Three Dimensional ◽  
High Strength ◽  
Biological Properties ◽  
Bone Tissue Regeneration

A novel, three-dimensional, porous, human-like collagen (HLC)/nano-hydroxyapatite (n-HA) scaffold cross-linked by 1,2,7,8-diepoxyoctane (DEO) was successfully fabricated, which showed excellent mechanical and superior biological properties for bone tissue regeneration in this study. The physicochemical characterizations of different n-HA/HLC/DEO (nHD) scaffolds were investigated by determining the morphology, compression stress, elastic modulus, Young’s modulus and enzymatic hydrolysis behavior in vitro. The results demonstrated that nHD-2 and nHD-3 scaffolds showed superior mechanical properties and resistance to enzymatic hydrolysis compared to nHD-1 scaffolds. The cell viability, live cell staining and cell adhesion analysis results demonstrated that nHD-2 scaffolds exhibited low cytotoxicity and excellent cytocompatibility compared with nHD-1 and nHD-3 scaffolds. Furthermore, subcutaneous injections of nHD-2 scaffolds in rabbits produced superior anti-biodegradation effects and histocompatibility compared with injections of nHD-1 and nHD-3 scaffolds after 1, 2 and 4 weeks. In addition, the repair of bone defects in rabbits demonstrated that nHD-2 scaffolds presented an improved ability for guided bone regeneration and reconstruction compared to commercially available bone scaffold composite hydroxyapatite/collagen (HC). Collectively, the results show that nHD-2 scaffolds show promise for application in bone tissue engineering due to their excellent mechanical properties, anti-biodegradation, anti-biodegradation, biocompatibility and bone repair effects.

Adaptable metamaterials based on biodegradable composites for bone tissue regeneration

2020 ◽  
pp. 44-58
Author(s):  
P. V. Evdokimov ◽  
◽  
V. I. Putlayev ◽  
N. K. Orlov ◽  
A. A. Tikhonov ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Interstitial Fluid ◽  
Bone Tissue Regeneration ◽  
Polymer Scaffolds ◽  
Biodegradable Composites ◽  
Relative Rigidity ◽  
Calcium Phosphate Layer ◽  
Unit Cells

The influence of lattice and shell type architecture on the mechanical properties of biodegradable polymer scaffolds designed to create structures for bone tissue engineering is investigated. Varying the topology of nodal connections allows you to control the relative rigidity of the metamaterial in the range from 0.004 to 0.123. The possibility of creating permeable scaffolds using thermally extruded 3D printing based on polymers of different elasticities - polylactide and polyurethane is shown. The use of “unit cells” of various types makes it possible to fabricate structures such as shells based on polylactide with a compressive strength of 1.5 to 19.7 MPa. Shells with a cubic type architecture based on polyurethane can be almost reversibly deformed at values of technical deformation of more than 50 %. The developed approaches for obtaining polymer metamaterials and modifying their surface with calcium phosphate layer using an artificial interstitial fluid can increase the hydrophilicity of materials.

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