Targeting cancer cells with controlled release nanocapsules based on a single aptamer

2013 ◽  
Vol 49 (13) ◽  
pp. 1285 ◽  
Author(s):  
Frank J. Hernandez ◽  
Luiza I. Hernandez ◽  
Alessandro Pinto ◽  
Thomas Schäfer ◽  
Veli C. Özalp
Keyword(s):  
Controlled Release ◽  
Cancer Cells

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

Intelligent micro-vehicles for drug transport and controlled release to cancer cells

2021 ◽  
pp. 104961
Author(s):  
Marieta Constantin ◽  
Sanda Bucatariu ◽  
Irina Popescu ◽  
Bogdan Cosman ◽  
Paolo Ascenzi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Cells ◽  
Drug Transport

Oxime-based 19-nortestosterone–pheophorbide a conjugate: bimodal controlled release concept for PDT

2019 ◽  
Vol 7 (36) ◽  
pp. 5465-5477 ◽  
Author(s):  
Vladimíra Pavlíčková ◽  
Michal Jurášek ◽  
Silvie Rimpelová ◽  
Kamil Záruba ◽  
David Sedlák ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Androgen Receptor ◽  
Controlled Release ◽  
Cancer Cells ◽  
Pheophorbide A

Nandrolone–pheophorbide a fluorescent conjugate exhibiting promising potential in targeting of androgen receptor-positive cancer cells and their destruction by photodynamic therapy.

Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells

2015 ◽  
Vol 16 (7) ◽  
pp. 1924-1937 ◽  
Author(s):  
Elena Gallon ◽  
Teresa Matini ◽  
Luana Sasso ◽  
Giuseppe Mantovani ◽  
Ana Armiñan de Benito ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Triblock Copolymer ◽  
Ph Responsive

scholarly journals Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release

RSC Advances ◽  
2019 ◽  
Vol 9 (62) ◽  
pp. 36005-36010
Author(s):  
Bilge G. Tuna ◽  
Pinar B. Atalay ◽  
Gamze Kuku ◽  
E. Esma Acar ◽  
H. Kubra Kara ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Controlled Release ◽  
Antitumor Activity ◽  
Mesoporous Silica ◽  
Cell Surface ◽  
Hela Cell ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Cervical Cancer Cells

Carbendazim doped and aptamer-gate functionalized mesoporous silica nanoparticles targeted nucleolin on HeLa cell surface for specific delivery. This delivery system improved antitumor activity of carbendazim by about 3 folds increase of EC50 values.

scholarly journals Controlled release of targeted anti-leukemia drugs azacitidine and decitabine monitored using surface-enhanced Raman scattering (SERS) spectroscopy

2017 ◽  
Vol 6 (4) ◽  
pp. 125-132 ◽  
Author(s):  
Madison Smith ◽  
Maria Hepel
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A new targeted drug delivery system with controlled release of anti-cancer drugs, azacitidine and decitabine, was investigated to enhance the efficacy of cancer treatment and reduce the effects of high drug toxicity to healthy tissues. The proposed drug nanocarriers are based on gold nanoparticles (AuNPs) modified with mercaptobenzoic acid (MBA) linker to enable the immobilization of azacitidine (AZA) and decitabine (DAC) on AuNPs in the form of AuNP@MBA/AZA,DAC entities. The cancer cell recognition was accomplished by covalently binding folic acid (FA) ligands to para-aminothiophenol (PATP) in the mixed SAM shell on gold nanoparticle nanocarriers, AuNP@MBA,PATP. The FA ligand was used due to the strong expression of folic acid receptors (FR) in the membrane of cancer cells. This enables the functionalized carriers to target only cancer cells owing to the efficient FA-FR binding property. The amide bonds between the linkers and azacitidine/decitabine are pH sensitive and undergo acid hydrolysis in a low pH environment of the cytosol in cancer cells. Using the solutions of different pH, the release of azacitidine/decitabine was monitored by surface-enhanced Raman scattering spectroscopy (SERS) measurements of the MBA Raman modes at 1586 cm-1 and 1074 cm-1 . At pH 7.4, the release of the drug was found to be negligible, while at pH 4.0 and 5.5 a continuous drug release was observed over 3 hours. The utilization of SERS monitoring for the drug release was based on the strong Raman signals which are generated by the MBA linker when it is bound to a plasmonic AuNP. During the immobilization of azacitidine/decitabine on AuNP carriers, the SERS signals are strongly reduced due to the shielding by drug molecules but they increase sharply upon the drug release confirming the amide bond breakage and successful drug delivery.

High-Effective Gene Delivery Based on Cyclodextrins Multivalent Assembly in Target Cancer Cells

2022 ◽  
Author(s):  
Yao-Hua Liu ◽  
Yu Liu
Keyword(s):  
Gene Therapy ◽  
Controlled Release ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Cancer Cells ◽  
Chemical Biology ◽  
Supramolecular Assembly ◽  
Target Cancer

Nucleic acids condensation and controlled release remain significant challenges of gene therapy in chemical biology and nanotechnology fields. In this work, we have reported a polysaccharide supramolecular assembly constructed by...

Development of the Anticancer Potential of a Chlorogenate-Zinc Layered Hydroxide Nanohybrid with Controlled Release Property Against Various Cancer Cells

2013 ◽  
Vol 5 (12) ◽  
pp. 1983-1993 ◽  
Author(s):  
Farahnaz Barahuie ◽  
Mohd Zobir Hussein ◽  
Palanisamy Arulselvan ◽  
Sharida Fakurazi ◽  
Zulkarnain Zainal
Keyword(s):  
Controlled Release ◽  
Cancer Cells ◽  
Release Property ◽  
Zinc Layered Hydroxide
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