A reversible near-infrared fluorescence probe for reactive oxygen species based on Te–rhodamine

2012 ◽  
Vol 48 (25) ◽  
pp. 3091 ◽  
Author(s):  
Yuichiro Koide ◽  
Mitsuyasu Kawaguchi ◽  
Yasuteru Urano ◽  
Kenjiro Hanaoka ◽  
Toru Komatsu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Near Infrared Fluorescence

scholarly journals Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis

2018 ◽  
Vol 9 (30) ◽  
pp. 6340-6347 ◽  
Author(s):  
Penghui Cheng ◽  
Jianjian Zhang ◽  
Jiaguo Huang ◽  
Qingqing Miao ◽  
Chenjie Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Molecular Probes ◽  
Fluorescence Probes ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Near Infrared Fluorescence

Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of keloid diseases.

scholarly journals Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Simona-Adriana Manea ◽  
Mihaela-Loredana Vlad ◽  
Daniela Rebleanu ◽  
Alexandra-Gela Lazar ◽  
Ioana Madalina Fenyo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
High Resolution ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Experimental Models ◽  
Fluorescent Imaging ◽  
Quantitative Detection ◽  
Oxygen Species ◽  
Near Infrared Fluorescence ◽  
Models Of Disease

Excessive production of reactive oxygen species (ROS) and the ensuing oxidative stress are instrumental in all phases of atherosclerosis. Despite the major achievements in understanding the regulatory pathways and molecular sources of ROS in the vasculature, the specific detection and quantification of ROS in experimental models of disease remain a challenge. We aimed to develop a reliable and straightforward imaging procedure to interrogate the ROS overproduction in the vasculature and in various organs/tissues in atherosclerosis. To this purpose, the cell-impermeant ROS Brite™ 700 (RB700) probe that produces bright near-infrared fluorescence upon ROS oxidation was encapsulated into VCAM-1-targeted, sterically stabilized liposomes (VLp). Cultured human endothelial cells (EC) and macrophages (Mac) were used for in vitro experiments. C57BL6/J and ApoE-/- mice were randomized to receive normal or high-fat, cholesterol-rich diet for 10 or 32 weeks. The mice received a retroorbital injection with fluorescent tagged VLp incorporating RB700 (VLp-RB700). After two hours, the specific signals of the oxidized RB700 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (NBD-DSPE), inserted into liposome bilayers, were measured ex vivo in the mouse aorta and various organs by high-resolution fluorescent imaging. VLp-RB700 was efficiently taken up by cultured human EC and Mac, as confirmed by fluorescence microscopy and spectrofluorimetry. After systemic administration in atherosclerotic ApoE-/- mice, VLp-RB700 were efficiently concentrated at the sites of aortic lesions, as indicated by the augmented NBD fluorescence. Significant increases in oxidized RB700 signal were detected in the aorta and in the liver and kidney of atherosclerotic ApoE-/- mice. RB700 encapsulation into sterically stabilized VCAM-1-sensitive Lp could be a novel strategy for the qualitative and quantitative detection of ROS in the vasculature and various organs and tissues in animal models of disease. The accurate and precise detection of ROS in experimental models of disease could ease the translation of the results to human pathologies.

Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapyin Vitro

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 7260-7271 ◽  
Author(s):  
Liang Gao ◽  
Ru Liu ◽  
Fuping Gao ◽  
Yaling Wang ◽  
Xinglu Jiang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light ◽  
Gold Nanocages

Plasmonic Enhanced Reactive Oxygen Species Activation on Low‐Work‐Function Tungsten Nitride for Direct Near‐Infrared Driven Photocatalysis

Small ◽  
2020 ◽  
Vol 16 (45) ◽  
pp. 2004557
Author(s):  
Weicheng Huang ◽  
Yan Gao ◽  
Jinxin Wang ◽  
Pengcheng Ding ◽  
Mei Yan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Work Function ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Tungsten Nitride ◽  
Oxygen Species

Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

scholarly journals Plasmonic Hot-Electron Reactive Oxygen Species Generation: Fundamentals for Redox Biology

2020 ◽  
Vol 8 ◽  
Author(s):  
Elisa Carrasco ◽  
Juan Carlos Stockert ◽  
Ángeles Juarranz ◽  
Alfonso Blázquez-Castro
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Chemical Reactivity ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Hot Electron ◽  
Redox Biology

For decades, the possibility to generate Reactive Oxygen Species (ROS) in biological systems through the use of light was mainly restricted to the photodynamic effect: the photoexcitation of molecules which then engage in charge- or energy-transfer to molecular oxygen (O2) to initiate ROS production. However, the classical photodynamic approach presents drawbacks, like per se chemical reactivity of the photosensitizing agent or fast molecular photobleaching due to in situ ROS generation, to name a few. Recently, a new approach, which promises many advantages, has entered the scene: plasmon-driven hot-electron chemistry. The effect takes advantage of the photoexcitation of plasmonic resonances in metal nanoparticles to induce a new cohort of photochemical and redox reactions. These metal photo-transducers are considered chemically inert and can undergo billions of photoexcitation rounds without bleaching or suffering significant oxidative alterations. Also, their optimal absorption band can be shape- and size-tailored in order to match any of the near infrared (NIR) biological windows, where undesired absorption/scattering are minimal. In this mini review, the basic mechanisms and principal benefits of this light-driven approach to generate ROS will be discussed. Additionally, some significant experiments in vitro and in vivo will be presented, and tentative new avenues for further research will be advanced.

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