Suitability of GaP nanoparticles as a surface-assisted laser desorption/ionization mass spectroscopy inorganic matrix and their soft ionization ability

The Analyst ◽  
2013 ◽  
Vol 138 (4) ◽  
pp. 995 ◽  
Author(s):  
Tetsu Yonezawa ◽  
Hiroki Tsukamoto ◽  
Shinji Hayashi ◽  
Yuki Myojin ◽  
Hideya Kawasaki ◽  
...  
Keyword(s):  
Mass Spectroscopy ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Soft Ionization ◽  
Desorption Ionization ◽  
Ionization Mass Spectroscopy ◽  
Inorganic Matrix

Carbon/Nafion® Nanocomposite Thin Films as Potential Matrix-free Laser Desorption-Ionization Mass Spectroscopy Substrates

2003 ◽  
Vol 788 ◽  
Author(s):  
A. Kaan Kalkan ◽  
Stephen J. Fonash
Keyword(s):  
Thin Films ◽  
Mass Spectroscopy ◽  
Laser Desorption ◽  
Low Noise ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Strong Light ◽  
Desorption Ionization ◽  
Ionization Mass Spectroscopy ◽  
Nanocomposite Thin Films

ABSTRACTCarbon/Nafion® nanocomposite thin films developed through a low-cost procedure were shown to function as high-sensitivity, low-noise, high-throughput laser desorption-ionization mass spectroscopy substrates for small molecule detection without the need of organic matrices. Our nanocomposite approach combines the strong light absorption feature of amorphous carbon with Nafion®'s efficient protonating capability to yield superior laser desorption-ionization.

scholarly journals The effect of different fatty acid sources on wound healing in rats assessed by matrix-assisted-laser-desorption-ionization mass-spectroscopy-imaging

2019 ◽  
Vol 88 (4) ◽  
pp. 443-449
Author(s):  
Tomáš Komprda ◽  
Zbyšek Sládek ◽  
Veronika Švehlová ◽  
Zuzana Lacková ◽  
Roman Guráň ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mass Spectroscopy ◽  
Laser Desorption ◽  
Control Fish ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Ionization Mass Spectroscopy ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

The objective of the present study was to compare the effects of dietary oils containing polyunsaturated fatty acids (PUFA) n-3 and n-6, respectively, on cutaneous wound healing in rats, and to demonstrate the usefulness of the matrix-assisted-laser-desorption-ionization mass spectroscopy-imaging (MALDI MSI) method in this type of experiment. Superiority of PUFA n-3 in this context was the tested hypothesis. Four groups of male Wistar rats by twelve animals each were fed a diet with added 5% of palm oil (P; control), fish oil (F), Schizochytrium microalga oil (Sch) and safflower oil (S), respectively, for eight weeks. Consequently, dorsal full-thickness cutaneous excisions were performed, and selected markers of wound healing were evaluated 18 days post excision. The median of signal intensity corresponding to an amount of collagen α-1 (III) fragment, quantified using MALDI MSI, decreased in a sequence P > F > Sch > S (P < 0.001). Using haematoxylin-eosin staining of the histological preparations, semi-quantitatively assessed epithelium height tended to decrease in the order of P > S > Sch > F; the wound extent in the sequence of P > Sch > S > F; and the sequence of the progress of neo-angiogenesis was assessed as S > P > F ≈ Sch. It was concluded that the tested hypothesis was confirmed only partially: PUFA n-3 showed better results regarding the wound extent, but were inferior in terms of epithelium height and progress of neo-angiogenesis. This was the first time MALDI MSI was successfully employed for evaluating skin wound healing in a rat model.

Laser desorption ionization mass spectrometry of peptides on a hybrid CHCA organic–inorganic matrix

The Analyst ◽  
2014 ◽  
Vol 139 (15) ◽  
pp. 3748-3754 ◽  
Author(s):  
Clément Fleith ◽  
Sonia Cantel ◽  
Gilles Subra ◽  
Ahmad Mehdi ◽  
Jeremie Ciccione ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Inorganic Matrix

We report applications of new hybrid organic–inorganic silica based materials as laser desorption/ionization (LDI)-promoting surfaces for high-throughput identification of peptides.

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